Search results for "dab"
showing 10 items of 1280 documents
1122P Real-world analysis of dabrafenib plus trametinib in patients with BRAFV600-mutated melanoma brain metastases
2020
Targeted Therapies in Melanoma
2015
The standard approach for malignant melanoma is represented by surgical excision. In most cases, distant metastases develop. Until few years ago, the main strategies to treat metastatic melanoma were chemotherapy and cytokines with subsequent low efficacy and poor tolerability profile. In the last few years, a new biological therapy has become available for metastatic melanoma. It includes targeted therapy, such as BRAF inhibitors (vemurafenib and dabrafenib) and MEK inhibitors (trametinib), and immunotherapy, such as the monoclonal antibodies anti-CTLA-4 (ipilimumab) and anti-PD-1 (nivolumab and lambrolizumab). The different mechanisms of action of these new drugs imply a variability of ou…
Ontological information system for the selection of technologies for the treatment and disposal of organic waste: engineering and educational aspects
2021
The article proves a problem of information processing in the field of the structuring of information and decision-making in environmental engineering, including education in this field. This article presents the ontology-information model that was used to systematize waste treatment equipment. The article presents the use of an ontological algorithm “Polyhedron” for engineers and teachers. The algorithm consists of integrating ontological solutions from abstract to specific. The proposed model consists of a general ontology of “waste treatment technologies selection”, “waste treatment equipment selection” and “Ontology for the analysis of scientific publications”. Users of the system can i…
Modular Phosphole-Methano-Bridged-Phosphine(Borane) Ligands. Application to Rhodium-Catalyzed Reactions
2012
The synthesis of the phospholyl(phosphinoborane)methane air- and moisture-stable hybrid ligands 4a–f, starting from 1-phenylphospholes 1a–d, was performed via P–C bond coupling on the methano bridge. Two strategies were investigated, according to the phospholyl moiety used as a nucleophilic or an electrophilic reagent. In the first pathway, the phospholyl anions react with the easily available (chloromethyl)diphenylphosphine–borane 3 to afford ligands 4a–d in 29–67% isolated yields. In the second pathway, the phospholyl(dicyclohexylphosphinoborane)methane ligands 4e,f were synthesized in 18–23% yields, through a nucleophilic substitution on the cyanophosphole. Removal of the BH3 moiety on 4…
Efficient synthesis of racemic and chiral alkenyl sulfoxides by palladium-catalyzed Suzuki coupling
2010
Alkenyl sulfoxide derivatives are obtained in high yields through a palladium-catalyzed Suzuki/Miyaura cross-coupling reaction of racemic and chiral 1-halo sulfoxides with aryl and alkenyl boronic acids. Chiral substrates react with no loss of optical purity and high optical yields. The reaction takes place with different palladium catalysts, such as Pd(PPh 3 ) 4 or Pd(OAc) 2 /DABCO. Although nitrogen ligands like DABCO lead to an active palladium catalyst, they are less effective than the phosphine ones.
Effect of partner–agent model practice on microinsurance client value: Insight from microfinance institutions in Tanzania
2018
In absence of formal microinsurance to protect low-income people against natural and man-made disasters, the partnership between insurance companies and microfinance institutions (MFIs), also known as the Partner–Agent Model (PAM), is gaining global recognition from governments, practitioners, and donors for its potential role to deliver microinsurance. Although the model is still nascent in Tanzania, it has significantly increased microinsurance outreach. However, while the microinsurance landscape has been extensively studied, the effect of PAM practice on mandatory microinsurance client value has not received much attention. Therefore, this study examines how the PAM practice affects mic…
New light on an old debate: Does the RCN-PtCl2 bond include any back-donation? RCN←PtCl2 backbonding: Vs. the IR ν CN blue-shift dichotomy in organon…
2019
For a series of organonitrile [RCN (R = Me, CF3, Ph, CH3Ph, CF3Ph)] ligands, the nature of the N-Pt bond in the related cis-/trans-(RCN)2PtCl2 complexes has been computationally investigated by Density Functional Theory. A fragment based bond analysis has been performed in the canonical Kohn-Sham molecular orbitals framework, and it has been ultimately assessed that this bond is characterized both by N→Pt σ and by N←Pt π contributions. Voronoi Deformation Density charges further confirms the occurrence of N←Pt π interactions. Moreover, the Energy Decomposition Analysis-Natural Orbital for Chemical Valence (EDA-NOCV) method shows that the strength of the N←Pt π interaction is not negligible …
"Table 14" of "Kshort and Lambda production in pp interactions at sqrt(s) = 0.9 and 7 TeV measured with the ATLAS detector at the LHC"
2012
The production ratio between LAMBDABAR and LAMBDA baryons at 7000 GeV as a function of transverse momentum.
"Table 16" of "Kshort and Lambda production in pp interactions at sqrt(s) = 0.9 and 7 TeV measured with the ATLAS detector at the LHC"
2012
The production ratio between LAMBDABAR and LAMBDA baryons at 900 GeV as a function of transverse momentum.
"Table 15" of "Kshort and Lambda production in pp interactions at sqrt(s) = 0.9 and 7 TeV measured with the ATLAS detector at the LHC"
2012
The production ratio between LAMBDABAR and LAMBDA baryons at 900 GeV as a function of rapidity.