Search results for "dalit"

Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?—A trial-level meta-analysis in PD-L1 selecte…

2021

BACKGROUND: The advent of immuno-oncology (IO) represented a breakthrough in non-small cell lung cancer (NSCLC) therapy over the last few years. However, establishing the optimal therapeutic options among programmed death-ligand 1 (PD-L1) selected subgroups still addresses an unmet need in the clinical setting. METHODS: We performed a systematic review and finally included eleven first-line randomized controlled trials to compare efficacy and safety outcomes among first-line IO treatment strategies versus standard platinum-based chemotherapy (CT) according to PD-L1 expression level (<1%, 1–49%, ≥50%). Pooled hazard ratios (HRs) and risk ratios (RRs) for progression-free survival (PFS), over…

The Big Meaning of Small Messages: The Use of WhatsApp in Intergenerational Family Communication

2018

This study explores the use of WhatsApp instant messenger in extended families in two countries, Finland and Italy, that represent different family and communication cultures. Qualitative research material was collected in 2014/2015 from families consisting of three or more generations and living either in the same or different households. A directed approach to qualitative content analysis was applied in the analysis of the research data. The results of the study show that WhatsApp is considered to facilitate family interaction across generations. The success of WhatsApp in the family context accounts for two main factors: first, for the possibility to reach the whole family at once; and s…

Update endokrine Orbitopathie

2009

Etiology, Modalities of Zygomaticomaxillary Complex Fracture, open reduction and fixation.

2020

Background Zygomatic complex fracture is second most common mid face fracture and frequent amongst the maxillofacial trauma. Fracture pattern ranges from simple to comminuted and from minimally displaced to severely displaced depending on various factors. Material and methods 98 patients with zygomaticomaxillary complex fracture reporting during December 2017 to January 2020 were included in the study. On the basis of radiographic evaluation and computerized tomography scan (CT scan) with 3D reconstruction severity of fracture was assessed and different treatment options were selected. Results Road traffic accident accounted as the leading cause of fracture (57.1%) followed by self-fall (16…

Lip repositioning technique. A simple surgical procedure to improve the smile harmony

2018

Excessive gingival display is an esthetic concern for patients. It is a condition in which an overexposure of the maxillary gingiva (>3mm) is present during smiling. There are different etiologies of a gummy smile, such as vertical maxillary excess, short and hyperactive upper lip, altered passive eruption, anterior dentoalveolar extrusion, or a combination of these causes. The correct diagnosis of all etiologic factors is imperative for its appropriate management. Many techniques have been used to restore the dentogingival relation for the management of gummy smile. Lip repositioning is a conservative surgical technique used to treat excess gingival display. It is a largely unknown treatme…

Flow-chemiluminescence: a growing modality of pharmaceutical analysis.

2001

The present article deals with a review of the applications of the chemiluminescence to pharmaceutical analyses by using continuous-flow assemblies. A comprehensive study on the fundamentals of the chemiluminescence is also included.

Scaffolding for motivation by parents, and child homework motivations and emotions: Effects of a training programme

2018

Background and aims Based on the principles of scaffolding for motivation and on the assumptions of self-determination theory, two studies aimed to assess the role played by perceived parental autonomy-supportive scaffolding on child homework autonomous motivation, self-efficacy, affect, and engagement. Samples and results The results of Study 1, which involved 122 parents and their children, showed that the higher the parental autonomous motivation, the more their children perceived them as autonomy-supportive while scaffolding for motivation, and hence developed autonomous motivation, self-efficacy, and engagement in homework. In Study 2, 37 parents were involved in a four-session trainin…

Recommendations for neonatologists and pediatricians working in first level birthing centers on the first communication of genetic disease and malfor…

2021

Abstract Background Genetic diseases are chronic conditions with relevant impact on the lives of patients and their families. In USA and Europe it is estimated a prevalence of 60 million affected subjects, 75% of whom are in developmental age. A significant number of newborns are admitted in the Neonatal Intensive Care Units (NICU) for reasons different from prematurity, although the prevalence of those with genetic diseases is unknown. It is, then, common for the neonatologist to start a diagnostic process on suspicion of a genetic disease or malformation syndrome, or to make and communicate these diagnoses. Many surveys showed that the degree of parental satisfaction with the methods of c…

Neural networks engaged in milliseconds and seconds time processing: evidence from transcranial magnetic stimulation and patients with cortical or su…

2009

Here, we review recent transcranial magnetic stimulation studies and investigations in patients with neurological disease such as Parkinson's disease and stroke, showing that the neural processing of time requires the activity of wide range-distributed brain networks. The neural activity of the cerebellum seems most crucial when subjects are required to quickly estimate the passage of brief intervals, and when time is computed in relation to precise salient events. Conversely, the circuits involving the striatum and the substantia nigra projecting to the prefrontal cortex (PFC) are mostly implicated in supra-second time intervals and when time is processed in conjunction with other cognitiv…

Observation of the Decay B+→K+K−π+

2007

We report the observation of charmless hadronic decays of charged B mesons to the final state K + K − π + . Using a data sample of 347.5     fb − 1 collected at the Υ ( 4 S ) resonance with the BABAR detector, we observe 429 ± 43 signal events with a significance of 9.6 σ . We measure the inclusive branching fraction B ( B + → K + K − π + ) = [ 5.0 ± 0.5 ( stat ) ± 0.5 ( syst ) ] × 10 − 6 . Inspection of the Dalitz plot of signal candidates shows a broad structure peaking near 1.5     GeV / c 2 in the K + K − invariant mass distribution. We find the direct C P asymmetry to be consistent with zero.