Search results for "dam"
showing 10 items of 3828 documents
Biological effects of inorganic arsenic on primary cultures of rat astrocytes
2010
It is well established that inorganic arsenic induces neurotoxic effects and neurological defects in humans and laboratory animals. The cellular and molecular mechanisms of its actions, however, remain elusive. Herein we report the effects of arsenite (NaAsO2) on primary cultures of rat astrocytes. Cells underwent induction of heat shock protein 70 only at the highest doses of inorganic arsenic (30 and 60 microM), suggesting a high threshold to respond to stress. We also investigated arsenic genotoxicity with the comet assay. Interestingly, although cells treated with 10 microM arsenite for 24 h maintained >70% viability, with respect to untreated cells, high DNA damage was already observed…
[PP.07.19] ASSOCIATION OF MAXIMUM SPEED OF BLOOD PRESSURE RISE DURING 24-H ABPM WITH SUBCLINICAL RENAL DAMAGE IN ESSENTIAL HYPERTENSION
2017
Objective: Experimental studies documented that the mechanical injury of intravascular pressure on the vessel wall, which results in vascular remodelling and atherosclerosis, may be more closely associated to oscillatory than to steady laminar shear stress This suggests that the hypertensive patient's prognosis may depend not only on average BP level but also on the degree and rate of BP variation. Little is known about the relationships between early renal abnormalities and the rate of BP changes assessed by intermittent 24-h ambulatory BP monitoring (ABPM). Our study was aimed to analyse the relationships between subclinical renal damage (SRD), defined as the presence of microalbuminuria …
Metabolic syndrome in hypertensive patients: An unholy alliance
2014
For many years, it has been recognized that hypertension tends to cluster with various anthropometric and metabolic abnormalities including abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, glucose intolerance, insulin resistance and hyperuricemia. This constellation of various conditions has been transformed from a pathophysiological concept to a clinical entity, which has been defined metabolic syndrome (MetS). The consequences of the MetS have been difficult to assess without commonly accepted criteria to diagnose it. For this reason, on 2009 the International Diabetes Federation, the American Heart Association and other scientific organizations pro…
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum
2017
Thoracic aortic aneurysms rupture and dissection are among the most devastating vascular diseases, being characterized by elevated mortality, despite improvements in diagnostic imaging and surgical techniques. An increased aortic root diameter (ARD) represents the main risk factor for thoracic aortic dissection and rupture and for aortic valve regurgitation. Even though arterial hypertension is commonly regarded as a predisposing condition for the development of thoracic aorta aneurysms, the role of blood pressure (BP) as determinant of aortic root enlargement is still controversial. The use of different methods for indexation of ARD may have in part contributed to the heterogeneous finding…
Intraocular Telescopic System Design: Optical and Visual Simulation in a Human Eye Model
2016
Purpose. To design an intraocular telescopic system (ITS) for magnifying retinal image and to simulate its optical and visual performance after implantation in a human eye model. Methods. Design and simulation were carried out with a ray-tracing and optical design software. Two different ITS were designed, and their visual performance was simulated using the Liou-Brennan eye model. The difference between the ITS was their lenses’ placement in the eye model and their powers. Ray tracing in both centered and decentered situations was carried out for both ITS while visual Strehl ratio (VSOTF) was computed using custom-made MATLAB code. Results. The results show that between 0.4 and 0.8 mm of d…
Stochastic Vulnerability Assessment of Masonry Structures: Concepts, Modeling and Restoration Aspects
2019
A methodology aiming to predict the vulnerability of masonry structures under seismic action is presented herein. Masonry structures, among which many are cultural heritage assets, present high vulnerability under earthquake. Reliable simulations of their response to seismic stresses are exceedingly difficult because of the complexity of the structural system and the anisotropic and brittle behavior of the masonry materials. Furthermore, the majority of the parameters involved in the problem such as the masonry material mechanical characteristics and earthquake loading characteristics have a stochastic-probabilistic nature. Within this framework, a detailed analytical methodological approac…
Constitutional Perspective of the Guarantees of Application of Artificial Intelligence: the Inescapable Protection of Fundamental Rights
2020
espanolLa Inteligencia Artificial tiene un innegable efecto en la sociedad actual, por lo que su estudio respecto de sus efectos juridicos deviene necesario. Y, en consecuencia, el modo en que se ven afectados los derechos fundamentales tiene especial importancia. De ahi que en el presente trabajo se estudie la influencia de los algoritmos en la determinacion de las resoluciones judi-ciales, sobre todo desde el punto de vista de como afectaria esta cuestion al derecho a la tutela judicial efectiva, reconocida como derecho fundamental en el articulo 24 de la Constitucion espanola. EnglishArtificial Intelligence has an undeniable effect on today’s society, so its study regarding its legal eff…
A COMPARATIVE STUDY OF PHENOMENOLOGICAL MODELS OF MR BRAKE BASED ON NEURAL NETWORKS APPROACH
2013
In this paper a full-scale commercially available magnetorheological (MR) brake installed in a semi-active suspension (SAS) system is modeled and simulated. Two well-known phenomenological hysteresis models are explored: Bouc–Wen and Dahl ones. In particular, influence of their parameters on the response is evaluated and assessed. The next step is to introduce the artificial neural networks and discuss their application in the field of systems identification. Subsequently, two feedforward neural networks are created and trained to estimate parameters characterizing each of the MR damper models described. The semi-active suspension (SAS) system equipped with a MR brake is described and the …
Diverging Collectives: Artist-Run Spaces versus Warehouse Shows Comparative models of art production and cooperation among young British artists
2017
The paper addresses the case of artist-run spaces and warehouse shows in the United Kingdom between the 1980s and 1990s, a time when autonomous group shows and independent artist collectives sprawled particularly thanks to the engagement of a new generation of artists, among whom were found later celebrities such as Damien Hirst and Douglas Gordon. It will be argued that both artist-run spaces and warehouse shows were feasible solutions for young authors against art market barriers and economic crisis, although they held structural and organisational differences that would affect aesthetic outcomes and present art history with a shift in the model of the art collective.
Interpretācija kā mākslas darba nosacījums: Hansa Georga Gadamera un Artūra Danto teoriju salīdzinājums
2021
Bakalaura darba mērķis ir pierādīt, ka atšķirības Artūra Kolmena Danto un Hansa Georga Gadamera mākslas teorijās izriet no atšķirīga interpretācijas jēdziena traktējuma. Pirmajās divās nodaļās uzrādīšu to, kā interpretācija saistās ar mākslu katras teorijas ietvaros, bet trešajā nodaļā no interpretācijas jēdziena skatupunkta salīdzināšu līdzīgos un atšķirīgos aspektus abās pieejās. Kā galvenos saskares punktus starp abiem domātājiem identificēju: (1) Georga Vilhelma Frīdriha Hēgeļa ideju turpināšanu un iestrādāšanu savās teorijās, (2) klasiskās un modernās mākslas pretnostatījuma pārvarēšanu, savienojot abu veidu mākslas vienā izpratnes shēmā, (3) interpretācijas izvirzīšanu par galveno nos…