Search results for "database."
showing 10 items of 2119 documents
The FBN2 gene: new mutations, locus-specific database (Universal Mutation Database FBN2), and genotype-phenotype correlations.
2009
International audience; Congenital contractural arachnodactyly (CCA) is an extremely rare disease, due to mutations in the FBN2 gene encoding fibrillin-2. Another member of the fibrillin family, the FBN1 gene, is involved in a broad phenotypic continuum of connective-tissue disorders including Marfan syndrome. Identifying not only what is in common but also what differentiates these two proteins should enable us to better comprehend their respective functions and better understand the multitude of diseases in which these two genes are involved. In 1995 we created a locus-specific database (LSDB) for FBN1 mutations with the Universal Mutation Database (UMD) tool. To facilitate comparison of …
A mathematical study on effective wavenumber, an operative computation procedure, and its use with radiance-temperature relationships
2003
In this paper we study the existence of effective wavenumber for any sensor by means of simple mathematics. We implement a numeric algorithm, based on the developed mathematical background, into a computer program named 'srf2radi', which is freely available via anonymous File Transfer Protocol (FTP) at ftp://ftp.uv.es/pub/src/. The number of effective wavenumbers for each temperature and their accuracy are also computed and studied for NOAA-16 Advanced Very High Resolution Radiometer Version 3 (AVHRR/3) channel 4. These effective wavenumbers can be used to obtain radiance-temperature relationships with physical meaning for any sensor in user-defined temperature intervals.
DelveFS - An Event-Driven Semantic File System for Object Stores
2020
Data-driven applications are becoming increasingly important in numerous industrial and scientific fields, growing the need for scalable data storage, such as object storage. Yet, many data-driven applications cannot use object interfaces directly and often have to rely on third-party file system connectors that support only a basic representation of objects as files in a flat namespace. With sometimes millions of objects per bucket, this simple organization is insufficient for users and applications who are usually only interested in a small subset of objects. These huge buckets are not only lacking basic semantic properties and structure, but they are also challenging to manage from a tec…
Direct lookup and hash-based metadata placement for local file systems
2013
New challenges to file systems' metadata performance are imposed by the continuously growing number of files existing in file systems. The total amount of metadata can become too big to be cached, potentially leading to multiple storage device accesses for a single metadata lookup operation. This paper takes a look at the limitations of traditional file system designs and discusses an alternative metadata handling approach, using hash-based concepts already established for metadata and data placement in distributed storage systems. Furthermore, a POSIX compliant prototype implementation based on these concepts is introduced and benchmarked. A variety of file system metadata and data operati…
Opening the Door for the Opportunistic Use of Interim Financing: A Critical Assessment of the EU Draft Directive on Preventive Restructuring Framewor…
2018
The draft of the EU Directive on Preventive Restructuring Frameworks and Second Chance (the "Directive") provides rules for adopting reorganisation plans in order to avoid insolvency. The draft Directive also provides rules on the related problem of interim financing. According to the draft Directive, interim financing should be encouraged and not be made subject to clawback unless parties have committed fraud or acted in bad faith. The Directive thereby fails to recognise that finance transactions are too diverse in nature to provide the company and its financial creditors with a transaction avoidance free period. If the Directive is adopted in its current form, it will open the door for o…
Accounting for Emission Trading Schemes: A Still Open Debate
2014
AbstractEmission allowances form the common trading currency introduced by the European Emission Trading Scheme to cover the emission of greenhouse gases. This initiative forces companies to internalise environmental expenses, so that it has an impact on accounting practices. The aim of this note is to discuss some alternative views on how to record this economic transaction, which could help the International Accounting Standards Board to find an accepted proposal. Adopting a common approach would always be preferable to the current situation characterised by total discretion. Indeed relying on the business model as proposed by the Autorite des Normes Comptables and the European Financial …
Value Creation When Acquiring Public vs Private Firms. Spanish Evidence
2013
We investigate shareholder value creation of Spanish listed firms in response to announcements of acquisitions of unlisted companies and compare this experience to the purchase of listed firms over the period 1991–2011. Similar to foreign markets, acquirers of listed targets earn insignificant average abnormal returns. However, acquirers of listed targets that perform a first bid show significant negative abnormal returns. Acquirers of unlisted targets gain significant positive average abnormal returns. When we relate these results to company and transaction characteristics our evidence suggests that the listing status effect is mainly associated with the fact that unlisted firms tend to be…
The Global Alternative Finance Market Benchmarking Report
2021
For the first time, the Cambridge Centre for Alternative Finance has consolidated its annual regional reports to produce one global benchmarking report, with the intention of presenting world-wide online alternative finance data for 2018.This report presents the key findings from the CCAF annual global survey of online alternative finance. In all, 1,227 unique firms contributed to this study, providing 2,322 firm-level observations globally. Investigating in crowdfunding, P2P/marketplace lending or related capital raising activities, the study shows that 47 per cent of the firms were operating in two or more countries or jurisdictions. Highlights from the report In 2018, the global alternat…
Analysis of the Aggregate Financial Behaviour of Customers Using the Transtheoretical Model of Change
2014
Abstract The authors addressed the problem of aggregate financial behaviour of customers by using the transtheoretical model of change. Aggregate financial behaviour of customers was studied by analyzing payment cards, private pension savings and mortgage loans. The transheoretical model of change was chosen as a theoretical framework for the analysis. Conclusions are based on results of regression analysis of empirical evidence of customers’ financial behaviour relation to the given products during the time period 2001-2013 in Latvia and further logical inferences by authors, which are consistent with the chosen theoretical framework of the transtheoretical model of change
Contract and Asset Values in Venture Capital Financings
2009
In venture capital financings a venture capitalist buys some fraction of a company, for a stated amount of money, through preferred shares. It is common practice in empirical and theoretical analyses to infer from this transaction a value for the entire company, which we call the contract value. Owners do not hold shares with the same rights and so the contract value misrepresents the company value of all assets (asset value). This paper studies a stylized venture capital market, calculates the ratio of contract to asset value, and derives the expected returns both at the level of venture capital funds and at the company level. We study quantitatively the impact on econometric analyses and …