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showing 10 items of 3080 documents

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

2013

AM Vicente - Cross-Disorder Group of the Psychiatric Genomics Consortium Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in …

Netherlands Twin Register (NTR)MedizinInheritance PatternsSocial SciencesAUTISM SPECTRUM DISORDERSnosologyheritabilityCOMMON SNPS0302 clinical medicineCrohn DiseaseSCHIZOPHRENIAChildPsychiatric geneticsGenetics & HeredityMAJOR DEPRESSIVE DISORDERRISK0303 health sciencesATTENTION-DEFICIT/HYPERACTIVITY DISORDER120 000 Neuronal CoherenceMental DisordersVariantsBIPOLAR DISORDERASSOCIATIONGenomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3]Psychiatric DisordersCROHNS-DISEASE3. Good healthSchizophreniagenetic association studyMedical geneticsMajor depressive disorderSNPsAdultmedicine.medical_specialtygenetic etiologymedical geneticsDEFICIT HYPERACTIVITY DISORDERBiologyPolymorphism Single Nucleotidebehavioral disciplines and activitiesArticleGenomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3]HeritabilityGenetic Heterogeneity03 medical and health sciencesPrevalence of mental disordersmental disorders/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyGeneticsmedicineddc:61HumansAttention deficit hyperactivity disorderGenetic Predisposition to Disease[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyDCN PAC - Perception action and control NCEBP 9 - Mental healthddc:610Medizinische Fakultät » Universitätsklinikum Essen » LVR-Klinikum Essen » Klinik für Psychiatrie Psychosomatik und Psychotherapie des Kindes- und JugendaltersBipolar disorderPsychiatry030304 developmental biologyDepressive Disorder MajorGenome HumanGenetic heterogeneitymedicine.diseaseschizophreniaAttention Deficit Disorder with HyperactivityChild Development Disorders PervasivePerturbações do Desenvolvimento Infantil e Saúde Mental030217 neurology & neurosurgeryGenome-Wide Association Study
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The next-generation liquid-scintillator neutrino observatory LENA

2012

We propose the liquid-scintillator detector LENA (Low Energy Neutrino Astronomy) as a next-generation neutrino observatory on the scale of 50 kt. The outstanding successes of the Borexino and KamLAND experiments demonstrate the large potential of liquid-scintillator detectors in low-energy neutrino physics. LENA's physics objectives comprise the observation of astrophysical and terrestrial neutrino sources as well as the investigation of neutrino oscillations. In the GeV energy range, the search for proton decay and long-baseline neutrino oscillation experiments complement the low-energy program. Based on the considerable expertise present in European and international research groups, the …

Neutrino detectors; Liquid-scintillator detectors; Low-energy neutrinos; Proton decay; Longbaseline neutrino beamsParticle physicsPhysics - Instrumentation and Detectors[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Physics::Instrumentation and DetectorsSolar neutrinoAstrophysics::High Energy Astrophysical PhenomenaLongbaseline neutrino beamsFOS: Physical sciencesLow-energy neutrinos7. Clean energy01 natural sciencesHigh Energy Physics - ExperimentNONuclear physicsLiquid-scintillator detectorsHigh Energy Physics - Experiment (hep-ex)0103 physical sciences[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex][PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]Neutrino detectorsNeutrino oscillationInstrumentation and Methods for Astrophysics (astro-ph.IM)010303 astronomy & astrophysicsBorexinoPhysics010308 nuclear & particles physicsFísicaAstronomy and AstrophysicsInstrumentation and Detectors (physics.ins-det)Proton decaySolar neutrino problem[SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]Neutrino detectorddc:540Measurements of neutrino speedHigh Energy Physics::ExperimentNeutrinoNeutrino astronomyAstrophysics - Instrumentation and Methods for Astrophysics
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Investigation of hydrogen and deuterium impact on the release of tritium from two-phase lithium ceramics under reactor irradiation

2022

In the development of fusion energy, an important task is the study and improvement of tritium production technologies. In this case, one of the most promising materials for tritium generation is lithium ceramics. Considering the importance of the task, numerous studies are aimed at solving the problem of determining the parameters and mechanisms of tritium release in lithium-containing materials. This paper presents the results of a study of tritium release processes from two-phase lithium ceramics of Li$_{4}$SiO$_{4}$/Li$_{2}$TiO$_{3}$ during reactor irradiation when hydrogen and deuterium are injected into the chamber with irradiated samples. The mechanisms regularities of the tritium yi…

Neutron irradiationTechnologyTritium releaseNuclear and High Energy PhysicsNuclear Energy and EngineeringMaterials Science (miscellaneous)TK9001-9401Nuclear engineering. Atomic powerTritiumDeuteriumddc:600Two-phase lithium ceramicNuclear Materials and Energy
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Selectivity of cyclodextrins as a parameter to tune the formation of pseudorotaxanes and micelles supramolecular assemblies. A systematic SANS study

2011

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. We studied the formation of polypseudorotaxanes formed with cyclodextrins (CDs) threading a copolymer chain that forms self-assembled structures in water. The size of the CD cavity was chosen such that it is block selective with respect to the formation of inclusion complexes and therefore in terms of altering the structure of the copolymer self-assemblies in a systematic fashio…

Neutron scattering supramolecular chemistry cyclodextrin pseudorotaxaneschemistry.chemical_classificationMaterials scienceCyclodextrinSupramolecular chemistry02 engineering and technologyGeneral ChemistryNeutron scattering010402 general chemistry021001 nanoscience & nanotechnologyCondensed Matter Physics01 natural sciencesSmall-angle neutron scatteringMicelle0104 chemical sciencesCrystallographychemistryCopolymerddc:5300210 nano-technologySelectivityDissolutionSettore CHIM/02 - Chimica Fisica
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Neutron tomography of ancient lead artefacts

2014

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. The investigations presented here show the results of an epigraphic analysis on ancient Roman lead ingots rescued from shipwrecks along the coast of Sicily (Italy) by means of Neutron Tomography (NT). The artefacts, including a lead horn, can be dated back to a period between the 3rd and 1st century BC. The three dimensional NT reconstructions helped the decipherment of hidden s…

Neutron TomographyLead (geology)General Chemical EngineeringNeutron tomographyddc:540General Engineeringddc:660MineralogyContext (language use)DeciphermentArchaeologyGeologyAnalytical Chemistry
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Influence of E-smoking liquids on human periodontal ligament fibroblasts.

2014

Introduction: Over the last years, electronic cigarettes (ECs) have become more popular, particularly in individuals who want to give up smoking tobacco. The aim of the present study was to assess the influence of the different e-smoking liquids on the viability and proliferation of human periodontal ligament fibroblasts. Method and materials: For this study six test solutions with components from ECs were selected: lime-, hazelnut- and menthol-flavored liquids, nicotine, propylene glycol, and PBS as control group. The fibroblasts were incubated up to 96 h with the different liquids, and cell viability was measured by using the PrestoBlue® reagent, the ATP detection and the migration assay.…

NicotineCell SurvivalPeriodontal LigamentCellClinical NeurologyDentistryElectronic Nicotine Delivery SystemsAndrologyNicotinechemistry.chemical_compoundIn vitromedicinePeriodontal fiberHumansddc:610Viability assayGeneral DentistryIncubationCells CulturedCell proliferationMigration AssayDentistry(all)business.industryCell growthResearchSmokingFibroblastsMentholmedicine.anatomical_structureOtorhinolaryngologychemistryElectronic cigarettesNeurology (clinical)businessMentholmedicine.drugHeadface medicine
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Noise identification and sampling frequency determination for precise Pb isotopic measurements by quadrupole-based Inductively Coupled Plasma Mass Sp…

2000

Analytical precision of the isotope ratios measured by quadrupole-based ICP-MS is drastically controlled by the low- frequency noises which originate from nebulisation and vaporisation processes, and from sample introduction systems. The unde- sirable influence of these latter can be however reduced by choosing efficiently the operating parameters. In the present study , the choice of the stabilisation time necessary in peak jump mode, and the one of the number of sweeps are discussed in the light of noise power spectra obtained with various speeds of the peristaltic pump used as sample introduction system. Obviously, the settings proposed are probably efficient only on our own ICP-MS, but …

Noise power010504 meteorology & atmospheric sciencesoptimisation[SDV]Life Sciences [q-bio]Analytical chemistry010501 environmental sciencesMass spectrometry01 natural sciencesSpectral lineplombddc:550élément métalliqueMETHODOLOGIE;CONTROLE DE QUALITE;ANALYSEOptimisationmétal lourdCONTROLE DE QUALITEisotopeInductively coupled plasma mass spectrometryComputingMilieux_MISCELLANEOUS0105 earth and related environmental sciencesReproducibilityIsotopeChemistryGeneral EngineeringQuality controlmesureGeneral ChemistryInstrumental parametersspectrométrie de masse à plasmabruitLead isotope ratiosANALYSEInductively coupled plasma mass spectrometry13. Climate action[SDE]Environmental SciencesQuadrupoleprécision de la mesureNoiseMETHODOLOGIENoise (radio)Analusis
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Hyperfine anomaly in gold and magnetic moments of $I^{\pi}$ $= 11/2^{−}$ gold isomers

2020

Physical review / C 101(3), 034308 (2020). doi:10.1103/PhysRevC.101.034308

Nuclear Physics - Experimentddc:530Physics::Atomic Physics[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]Nuclear Structure530
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Direct X(3872) production in e+e- collisions

2014

Direct production of the charmonium-like state $X(3872)$ in $e^+e^-$ collisions is considered in the framework of the vector meson dominance model. An order-of-magnitude estimate for the width $\Gamma(X\to e^+e^-)$ is found to be $\gtrsim$0.03 eV. The same approach applied to the $\chi_{c1}$ charmonium decay predicts the corresponding width of the order 0.1 eV in agreement with earlier estimates. Experimental perspectives for the direct production of the $1^{++}$ charmonia in $e^+e^-$ collisions are briefly discussed.

Nuclear Theory (nucl-th)High Energy Physics - PhenomenologyHigh Energy Physics - Experiment (hep-ex)High Energy Physics - Phenomenology (hep-ph)Nuclear TheoryExotic hadronsFOS: Physical sciencesHigh Energy Physics::Experimentddc:530Charmoniumlcsh:Physicslcsh:QC1-999High Energy Physics - Experiment
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Nuclear Charge Radius of $^{12}$Be

2012

The nuclear charge radius of $^{12}$Be was precisely determined using the technique of collinear laser spectroscopy on the $2s_{1/2}\rightarrow 2p_{1/2, 3/2}$ transition in the Be$^{+}$ ion. The mean square charge radius increases from $^{10}$Be to $^{12}$Be by $\delta ^{10,12} = 0.69(5) \fm^{2}$ compared to $\delta ^{10,11} = 0.49(5) \fm^{2}$ for the one-neutron halo isotope $^{11}$Be. Calculations in the fermionic molecular dynamics approach show a strong sensitivity of the charge radius to the structure of $^{12}$Be. The experimental charge radius is consistent with a breakdown of the N=8 shell closure.

Nuclear Theory (nucl-th)Nuclear TheoryAtomic Physics (physics.atom-ph)Other Fields of Physicsddc:550FOS: Physical sciencesPhysics - Atomic Physics
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