Search results for "ddc:"
showing 10 items of 3080 documents
Search for ultrahigh-energy tau neutrinos with IceCube
2012
The first dedicated search for ultrahigh-energy (UHE) tau neutrinos of astrophysical origin was performed using the IceCube detector in its 22-string configuration with an instrumented volume of roughly 0.25 km3. The search also had sensitivity to UHE electron and muon neutrinos. After application of all selection criteria to approximately 200 live-days of data, we expect a background of 0.60±0.19(stat)+0.56−0.58(syst) events and observe three events, which after inspection, emerge as being compatible with background but are kept in the final sample. Therefore, we set an upper limit on neutrinos of all flavors from UHE astrophysical sources at 90% C.L. of E2νΦ90(νx)<16.3×10−8 GeV cm−2…
Search for neutrino-induced particle showers with IceCube-40
2013
We report on the search for neutrino-induced particle-showers, so-called cascades, in the IceCube-40 detector. The data for this search was collected between April 2008 and May 2009 when the first 40 IceCube strings were deployed and operational. Three complementary searches were performed, each optimized for different energy regimes. The analysis with the lowest energy threshold (2 TeV) targeted atmospheric neutrinos. A total of 67 events were found, consistent with the expectation of 41 atmospheric muons and 30 atmospheric neutrino events. The two other analyses targeted a harder, astrophysical neutrino flux. The analysis with an intermediate threshold of 25 TeV lead to the observation of…
A Search for a Diffuse Flux of Astrophysical Muon Neutrinos with the IceCube 40-String Detector
2011
The IceCube Neutrino Observatory is a 1 km$^{3}$ detector currently taking data at the South Pole. One of the main strategies used to look for astrophysical neutrinos with IceCube is the search for a diffuse flux of high-energy neutrinos from unresolved sources. A hard energy spectrum of neutrinos from isotropically distributed astrophysical sources could manifest itself as a detectable signal that may be differentiated from the atmospheric neutrino background by spectral measurement. This analysis uses data from the IceCube detector collected in its half completed configuration which operated between April 2008 and May 2009 to search for a diffuse flux of astrophysical muon neutrinos. A to…
Search for a diffuse flux of astrophysical muon neutrinos with the IceCube 59-string configuration
2013
A search for high-energy neutrinos was performed using data collected by the IceCube Neutrino Observatory from May 2009 to May 2010, when the array was running in its 59-string configuration. The data sample was optimized to contain muon neutrino induced events with a background contamination of atmospheric muons of less than 1%. These data, which are dominated by atmospheric neutrinos, are analyzed with a global likelihood fit to search for possible contributions of prompt atmospheric and astrophysical neutrinos, neither of which have yet been identified. Such signals are expected to follow a harder energy spectrum than conventional atmospheric neutrinos. In addition, the zenith angle dist…
First Observation of PeV-Energy Neutrinos with IceCube
2013
We report on the observation of two neutrino-induced events which have an estimated deposited energy in the IceCube detector of 1.04 $\pm$ 0.16 and 1.14 $\pm$ 0.17 PeV, respectively, the highest neutrino energies observed so far. These events are consistent with fully contained particle showers induced by neutral-current $\nu_{e,\mu,\tau}$ ($\bar\nu_{e,\mu,\tau}$) or charged-current $\nu_{e}$ ($\bar\nu_{e}$) interactions within the IceCube detector. The events were discovered in a search for ultra-high energy neutrinos using data corresponding to 615.9 days effective livetime. The expected number of atmospheric background is $0.082 \pm 0.004 \text{(stat)}^{+0.041}_{-0.057} \text{(syst)}$. T…
AP5Z1/SPG4 8 frequency in autosomal recessive and sporadic spastic paraplegia
2014
Hereditary spastic paraplegias (HSP) constitute a rare and highly heterogeneous group of neurodegenerative disorders, defined clinically by progressive lower limb spasticity and pyramidal weakness. Autosomal recessive HSP as well as sporadic cases present a significant diagnostic challenge. Mutations in AP5Z1, a gene playing a role in intracellular membrane trafficking, have been recently reported to be associated with spastic paraplegia type 48 (SPG48). Our objective was to determine the relative frequency and clinical relevance of AP5Z1 mutations in a large cohort of 127 HSP patients. We applied a targeted next-generation sequencing approach to analyze all coding exons of the AP5Z1 gene. …
Activation of Intestinal Epithelial Stat3 Orchestrates Tissue Defense during Gastrointestinal Infection
2015
Gastrointestinal infections with EHEC and EPEC are responsible for outbreaks of diarrheal diseases and represent a global health problem. Innate first-line-defense mechanisms such as production of mucus and antimicrobial peptides by intestinal epithelial cells are of utmost importance for host control of gastrointestinal infections. For the first time, we directly demonstrate a critical role for Stat3 activation in intestinal epithelial cells upon infection of mice with Citrobacter rodentium - a murine pathogen that mimics human infections with attaching and effacing Escherichia coli. C. rodentium induced transcription of IL-6 and IL-22 in gut samples of mice and was associated with activat…
Tristetraprolin regulation of interleukin-22 production
2015
AbstractInterleukin (IL)-22 is a STAT3-activating cytokine displaying characteristic AU-rich elements (ARE) in the 3′-untranslated region (3′-UTR) of its mRNA. This architecture suggests gene regulation by modulation of mRNA stability. Since related cytokines undergo post-transcriptional regulation by ARE-binding tristetraprolin (TTP), the role of this destabilizing protein in IL-22 production was investigated. Herein, we demonstrate that TTP-deficient mice display augmented serum IL-22. Likewise, IL-22 mRNA was enhanced in TTP-deficient splenocytes and isolated primary T cells. A pivotal role for TTP is underscored by an extended IL-22 mRNA half-life detectable in TTP-deficient T cells. Lu…
The gas-phase chemiionization reaction between samarium and oxygen atoms: A theoretical study
2004
The Sm + O chemiionization reaction has been investigated theoretically using a method that allows for correlation and relativistic effects. Potential energy curves have been calculated for several electronic states of SmO and SmO+. Comparison with available spectroscopic and thermodynamic values for these species is reported and a mechanism for the chemiionization reaction Sm + O is proposed. The importance of spin–orbit coupling in the excited states of SmO, in allowing this chemiionization reaction to take place, has been revealed by these calculations. This paper shows the metal-plus-oxidant chemiionization reaction.
Drift of the Earth’s Principal Axes of Inertia from GRACE and Satellite Laser Ranging Data
2020
The location of the Earth’s principal axes of inertia is a foundation for all the theories and solutions of its rotation, and thus has a broad effect on many fields, including astronomy, geodesy, and satellite-based positioning and navigation systems. That location is determined by the second-degree Stokes coefficients of the geopotential. Accurate solutions for those coefficients were limited to the stationary case for many years, but the situation improved with the accomplishment of Gravity Recovery and Climate Experiment (GRACE), and nowadays several solutions for the time-varying geopotential have been derived based on gravity and satellite laser ranging data, with time resolutions reac…