Search results for "death"

Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?

2019

In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other pathological symptoms become evident. It is not known whether this phenomenon is caused by mechanisms associated with cell death or if, conversely, it triggers apoptosis. When the phenomenon was studied in diseases such as Parkinson’s and Alzheimer’s or amyotrophic lateral sclerosis, it was attributed to a variety of causes, including the presence of cytoplasmatic protein aggregates, malfunctioning of intracellular traffic and/or alterations i…

Cell and molecular response to IORT treatment

2014

Ionizing radiations (IRs) generated by intraoperative radiotherapy (IORT) treatment activates both pro- and antiproliferative signal pathways producing an imbalance in cell fate decision regulated by several genes and factors involved in cell cycle progression, survival and/or cell death, DNA repair and inflammation. This paper describes the latest advances on cellular and molecular response to IR, highlighting the most relevant research data from cell biology, gene expression profiling and epigenetic studies on different tumor cell types. Understanding the cell molecular strategies to choose between death and survival, after an irradiation-induced damage, opens new avenues for the selectio…

Book Review : Seebach and Willerslev (eds), Mirrors of Passing

2019

The Taboo of the Perverse Dying Body

2014

A human being is continuously living towards death within a mortal body that is dying little by little, second after second. In the gloss of popular media, the taboo reality of this stain of mortality is hidden by a diversion, which is created by the multiple pornographies of visual culture: the pornography of perfect bodies and the pornography of violent death. No longer invisible or ‘unspeakable’, the taboo body has been appropriated to serve a function in the mainstream didactics. Both the lusus naturae of natural bodies and the decay of sickness and death are squeezed into such roles in the postmodern visual narrative that the mortality of the human being appears unlikely and accidental…

Association between ideal cardiovascular health and risk of sudden cardiac death and all-cause mortality among middle-aged men in Finland

2021

Background Strong associations have been demonstrated between the American Heart Association’s cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) is uncertain. We examined the associations between these CVH metrics and the risks of SCD and all-cause mortality among men in Finland. Methods and results We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study, which consists of men between 42 and 60 years of age at baseline. CVH metrics were computed for 2577 men with CVH scores at baseline ranging from 0 to 7, categorized into CVH scores of 0–2 (poor), 3–4 (intermediate) and 5–7 (ideal). Mult…

Leisure-Time Physical Activity and All-Cause Mortality : A Systematic Review

2022

Many scientific studies have been shown the positive effect of physical activity (PA) on reducing morbidity and mortality, whereas physical inactivity is globally one of the leading factors in mortality. Therefore, the purpose was to investigate the relationship between leisure-time physical activity (LTPA) and all-cause mortality among adult population. The data search was performed of 3 electronic databases for the years 2000-2021 February as follows: Google Scholar, PubMed, and ResearchGate. This search was made by using the following terms and operators AND/OR, individually/combination: "physical activity", "physical fitness", "leisure-time physical activity", "all-cause mortality", "ri…

Sleep Duration and Risk of Fatal Coronary Heart Disease, Sudden Cardiac Death, Cancer Death, and All-Cause Mortality

2018

Background: Sleep duration has been shown to be associated with all-cause mortality, however its relationship with cause-specific fatal events remains uncertain. We examined the relationship between sleep duration and risk of fatal coronary heart disease (CHD), sudden cardiac death, cancer related death and all-cause mortality. Methods Sleep duration was self-reported at baseline examinations performed between March 20, 1984 and December 5, 1989 in 2,361 men aged 42-61 years old from the Kuopio Ischemic Heart Disease study. Of these 1734 (73.4%) men were free from CHD and cancer at baseline. Results: A total of 802 all cause deaths, 202 fatal coronary heart disease events, 141 sudden cardia…

Härmistetty kuolema: pelonhallintaa zombi-kuvakirjoissa

2018

Artikkeli tarkastelee zombikuvakirjojen tapoja käsitellä zombeissa ruumiillistuvaa rumaa ja väkivaltaista kuolemaa. Se keskittyy erityisesti tapoihin, joilla zombeihin liittyviä pelkoja pyritään kuvakirjoissa hallitsemaan. Kaunistavan, tieteellisiä selityksiä painottavan estetisoinnin lisäksi se tarttuu esteettisen härmistämisen käsitteeseen, eräänlaiseen naurettavaksi tekevään rumentamiseen, jonka se liittää taikauskoon ja kuvamagiaan. Vaikka esteettistä härmistämistä voidaan pitää animistisuudessaan jossain määrin primitiivisenä ja lapsellisena esitystapana, artikkeli esittää, että se on lopulta melko yleinen populaarikulttuurinen pelonhallinnan tapa. Alentaessaan ja karnevalisoidessaan y…

Fabry Disease, a Complex Pathology Not Easy to Diagnose

2015

Fabry disease is a multisystemic lysosomal storage disorder, inherited in an X-linked manner. It is a defect of metabolism of the glycosphingolipids, due to the reduction or absence of the activity of lysosomal enzyme α-galactosidase A. This reduction of activity causes the storage of globotriaosylceramide and derivatives in the lysosomes, triggering a cascade of cellular events, mainly in vascular endothelium. These events are the responsible for the systemic clinical manifestations and the renal, cardiac and cerebrovascular complications, or a combination of them. The symptomatology can lead to the premature death of patient between the fourth or fifth decade of life. The first symptoms c…

Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1

2018

Immunomodulatory drugs and monoclonal antibody-based immunotherapies have significantly improved the prognosis of the patients with multiple myeloma (MM) in the recent years. These new classes of reagents target malignant plasma cells (PCs) and further modulate the immune microenvironment, which prolongs anti-MM responses and may prevent tumor occurrence. Since MM remains an incurable cancer for most patients, there continues to be a need to identify new tumor target molecules and investigate alternative cellular approaches using gene therapeutic strategies and novel treatment mechanisms. Osteoclasts (OCs), as critical multi-nucleated large cells responsible for bone destruction in >80% …