Search results for "death"
showing 10 items of 1744 documents
TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex
2021
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills various cancer cell types, but also leads to the activation of signaling pathways that favor resistance to cell death. Here, we investigated the as yet unknown roles of calcium signaling and autophagy regulatory proteins during TRAIL-induced cell death in leukemia cells. Taking advantage of the Gene Expression Profiling Interactive Analysis (GEPIA) project, we first found that leukemia patients present a unique TRAIL receptor gene expression pattern that may reflect their resistance to TRAIL. The exposure of NB4 acute promyelocytic leukemia cells to TRAIL induces intracellular Ca2+ influx through a calcium rel…
Victors, Vanquished and Neutrals: The Swedish Press and the Nuremberg Trial
2011
After the shock of the ghastly revelations from the liberated concentration camps began to wane in late spring 1945, there was little written on the Nazi genocide in the Swedish press until autumn 1945. As elsewhere, the attention and energies of the newspaper media were directed to covering other tumultuous events of the world. For example, the Swedish press followed closely the developments in its neighbouring countries — not least Finland, which seemed to be on the verge of a Soviet-instigated coup, and therefore caused a lot of anxiety and discussion in the Swedish press. In line with the concept of Nordic Brotherhood, as discussed in Chapter 3, the Swedish press functioned as a channel…
Si esto es un padre
2016
E<span>n la película de László Nemes, El hijo de Saúl (2015), el protagonista encuentra a un niño agonizante que ha sobrevivido a la cámara de gas en el campo de Auschwitz-Birkenau y a quien después un médico de las SS asfixia con sus propias manos. La escena de este asesinato confronta a Saúl (Géza Röhrig) en sus límites como viviente; decide con determinación entonces que este cadáver no se sumará a la maquinaria de muerte que es el campo de exterminio y busca desesperadamente un rabino para enterrarlo. Este artículo analiza la enigmática obstinación de este personaje en relación con los límites de la vida humana que puso en juego el nazismo y con los límites visuales de la represen…
Proyecto de intervención antropológica en el sepulcrodel canciller villaespesa (catedral de tudela). Crónica de un intento fallido.
2021
Goal: However, the project presented here tries, on the one hand, to focus their objectives on very specific perspectives that are linked to a matter of absolute actuality in the field of humanities research, the construction of power. From that perspective, it aims to analyze the use of the death as an instrument of power and representation by the dominant elites in society and in the articulation of collective political and cultural values. It also aims to orientate from a line of clear interdisciplinary work (history, art, literacy, philosophy, music, epigraphy, codicology, anthropology ect.), that can build a broader interpretive prism and deeper analysis.
Afrontamiento de la muerte en familiares de pacientes ingresados en una unidad de cuidados intensivos: Valoración diferencial en función de variables…
2011
Objective to analyze the main factors that could help to face one's own death from relatives of ICU patients perspective, taking into account the influence of sociodemographic variables (gender, age, marital status and educational level). Material and method a descriptive study was carried out with family members of patients admitted to the ICU in the General Hospital (Castellón, Spain) (October 2008- December 2009). From 53 initial interviews, 26% of subjects were excluded of the study, so the total sample was made up of 39 relatives who voluntarily answered the Helping to Die in Peace Questionnaire. Results the most relevant factors that could help relatives at the time of death would be …
Galvenie neoplastiko nāves gadījumu cēloņi Latvijā
2021
Nosaukums: Nāves gadījumu ne neoplāziju dēļ galvenie cēloņi Latvijā Ievads: Izplatītāko mirstības ne neoplāziju dēļ cēloņu epidemioloģiskā novērošana visā pasaulē un Eiropas Savienībā salīdzinājumā ar Latviju. Mērķi: Šī pētījuma galvenais mērķis ir salīdzināt galvenos nāves ne neoplāziju dēļ cēloņus Latvijā un pasaulē, kā arī novērtēt jebkuras būtiskas izmaiņas mirstības rādītājos un korelācijās ar iepriekšējiem gadiem ar rezultātu turpmāko korelāciju izvērtēšanu. Materiāli un metodes: Statistiskās vērtības tika izgūtas no Latvijas Veselības statistikas datu bāzes ar pētāmo populāciju, kurā tika iekļauti abu dzimumu pārstāvji, ar trim galvenajām vecuma grupām: vecums 0-14 gadu, 15-59 gadu u…
The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
2019
BackgroundCongenital Toxoplasmosis (CT) can have severe consequences. France, Austria, and Slovenia have prenatal screening programs whereas some other countries are considering universal screening to reduce congenital transmission and severity of infection in children. The efficiency of such programs is debated increasingly as seroprevalence among pregnant women and incidence of congenital toxoplasmosis show a steady decrease. In addition, uncertainty remains regarding the effectiveness of pre- and postnatal treatments.MethodTo identify cost-effective strategies, prenatal and neonatal screenings were compared using a decision-analytic model based on French guidelines and current knowledge …
Applications and Limitations of Dendrimers in Biomedicine
2020
Biomedicine represents one of the main study areas for dendrimers, which have proven to be valuable both in diagnostics and therapy, due to their capacity for improving solubility, absorption, bioavailability and targeted distribution. Molecular cytotoxicity constitutes a limiting characteristic, especially for cationic and higher-generation dendrimers. Antineoplastic research of dendrimers has been widely developed, and several types of poly(amidoamine) and poly(propylene imine) dendrimer complexes with doxorubicin, paclitaxel, imatinib, sunitinib, cisplatin, melphalan and methotrexate have shown an improvement in comparison with the drug molecule alone. The anti-inflammatory therapy focus…
Fiber intake and all-cause mortality in the Prevención con Dieta Mediterránea (PREDIMED) study
2014
Background: Few observational studies have examined the effect of dietary fiber intake and fruit and vegetable consumption on total mortality and have reported inconsistent results. All of the studies have been conducted in the general population and typically used only a single assessment of diet. Objective: We investigated the association of fiber intake and whole-grain, fruit, and vegetable consumption with all-cause mortality in a Mediterranean cohort of elderly adults at high cardiovascular disease (CVD) risk by using repeated measurements of dietary information and taking into account the effect of a dietary intervention. Design: We followed up 7216 men (55-75 y old) and women (60-75 …
NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
2002
The production of new neurons declines during adulthood and persists, although at very low levels, in the aged hippocampus. Since neurogenesis in young adults has been related to learning and memory, its reduction may contribute to the age-related impairments in these abilities. Adrenalectomy (ADX) enhances neurogenesis in the aged hippocampus, although it also induces neuronal cell death. Since the administration of an NMDA receptor antagonist enhances neurogenesis in young adult rats without deleterious morphological effects, we have tested whether neurogenesis could be reactivated in aged rats. Our study shows that cell proliferation, cell death, neurogenesis and the number of radial gli…