Search results for "death"

showing 10 items of 1744 documents

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

2015

// Stefania Raimondo 1 , Flores Naselli 1 , Simona Fontana 1 , Francesca Monteleone 1 , Alessia Lo Dico 1 , Laura Saieva 1 , Giovanni Zito 2 , Anna Flugy 1 , Mauro Manno 3 , Maria Antonietta Di Bella 1 , Giacomo De Leo 1 , Riccardo Alessandro 1 1 Dipartimento di Biopatologia e Biotecnologie Mediche, Universita degli Studi di Palermo, sezione di Biologia e Genetica, Palermo, Italy 2 Laboratorio di Ingegneria Tissutale – Piattaforme Innovative per l’Ingegneria Tissutale (PON01–00829), Istituto Ortopedico Rizzoli, Palermo, Italy 3 Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Palermo, Italy Correspondence to: Riccardo Alessandro, e-mail: riccardo.alessandro@unipa.it Keywords: canc…

MaleProteomicsCitrusCell signalingProgrammed cell deathTime Factorsexosome-like nanovesiclesCell SurvivalCellApoptosisMice SCIDBiologyExosomesTNF-Related Apoptosis-Inducing LigandCitrus limon L.; TRAIL-mediated cell death; cancer; exosome-like nanovesiclesCitrus limon L.Mice Inbred NODCell Line TumorLeukemia Myelogenous Chronic BCR-ABL PositiveHuman Umbilical Vein Endothelial CellsmedicinecancerAnimalsHumansCell ProliferationPlant ProteinsPlants MedicinalPlant ExtractsCell growthCancermedicine.diseaseTRAIL-mediated cell deathAntineoplastic Agents PhytogenicXenograft Model Antitumor AssaysMicrovesiclesTumor BurdenFruit and Vegetable Juicesmedicine.anatomical_structureOncologyApoptosisImmunologyCancer researchNanoparticlesSignal transductionResearch PaperPhytotherapySignal Transduction
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Disability in moderate chronic obstructive pulmonary disease: Prevalence, burden and assessment-results from a real-life study

2014

<b><i>Background:</i></b> The role of disability and its association with patient-reported outcomes in the nonsevere forms of chronic obstructive pulmonary disease (COPD) has never been explored. <b><i>Objectives:</i></b> The aim of this study was to assess, in a cross-sectional real-life study, the prevalence and degree of disability in moderate COPD patients and to assess its association with health status, illness perception, risk of death and well-being. <b><i>Methods:</i></b> Moderate COPD outpatients attending scheduled visits were involved in a quantitative research program using a questionnaire-based data collec…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyChronic ObstructiveActivities of daily livingCross-sectional studyHealth StatusPulmonary diseaseChronic obstructive pulmonary disease; Disability; Patient-reported outcomes; Activities of Daily Living; Aged; Cross-Sectional Studies; Disability Evaluation; Female; Health Status; Humans; Italy; Male; Middle Aged; Pulmonary Disease Chronic Obstructive; Pulmonary and Respiratory MedicineSettore MED/10 - Malattie Dell'Apparato RespiratorioChronic obstructive pulmonary disease; Disability; Patient-reported outcomes; Activities of Daily Living; Aged; Cross-Sectional Studies; Disability Evaluation; Female; Health Status; Humans; Italy; Male; Middle Aged; Pulmonary Disease Chronic Obstructive; Pulmonary and Respiratory Medicine; Medicine (all)Illness perceptionsPulmonary DiseasePulmonary Disease Chronic ObstructiveDisability EvaluationActivities of Daily LivingMedicineHumansDisease burdenAgedCOPDDisabilityPatient-reported outcomesbusiness.industryMedicine (all)Chronic obstructive pulmonary diseaseMiddle Agedmedicine.diseaseCross-Sectional StudiesItalyPhysical therapyFemaleRisk of deathbusinessLife study
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COPD at the end of life: Predictors of the emotional distress of patients and their family caregivers.

2020

BackgroundFew studies have focused on patients' emotional distress with end-stage chronic obstructive pulmonary disease (COPD) and their main family caregivers.MethodsCross-sectional data about emotional, functional, and burden-related variables were collected from 85 patients with end-stage COPD and their 85 respective main family caregivers to determine the variables that could predict their emotional well-being. Descriptive analyses, comparison of means, hierarchical regression models, and comparative quali-quantitative analyses were carried out.ResultsData show that the great majority of patients with COPD spend years with this diagnosis, and have been admitted to the hospital several t…

MalePulmonologyCross-sectional studyEmotionsSocial SciencesDiseaseComorbidityAnxietyPsychological DistressSeverity of Illness IndexPulmonary Disease Chronic Obstructive0302 clinical medicineCost of IllnessSurveys and QuestionnairesMedicine and Health SciencesPsychology030212 general & internal medicineYoung adultAged 80 and overMultidisciplinaryFamily caregiversDepressionQRMiddle AgedHospitalsDeathDistressCaregivers030220 oncology & carcinogenesisMedicineAnxietyFemalemedicine.symptomClinical psychologyResearch ArticleAdultPatientsScienceChronic Obstructive Pulmonary Disease03 medical and health sciencesYoung AdultSeverity of illnessMental Health and PsychiatrymedicineHumansAgedbusiness.industryMood DisordersBiology and Life Sciencesmedicine.diseaseComorbidityHealth CareCross-Sectional StudiesHealth Care FacilitiesbusinessPloS one
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The Qualification of Outcome after Cervical Spine Surgery by Patients Compared to the Neck Disability Index

2016

Contains fulltext : 168196.PDF (Publisher’s version ) (Open Access) OBJECTIVE: The Neck Disability Index (NDI) is a patient self-assessed outcome measurement tool to assess disability, and that is frequently used to evaluate the effects of the treatment of neck-related problems. In individualized medicine it is mandatory that patients can interpret data in order to choose a treatment. A change of NDI or an absolute NDI is generally meaningless to a patient. Therefore, a correlation between the qualification of the clinical situation rated by the patient and the NDI score was evaluated. METHODS: Patients who completed an NDI after anterior surgery because of symptomatic single level degenera…

MaleQuestionnairesCervical spine surgeryMedical DoctorsHealth Care ProvidersStress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]Social Scienceslcsh:MedicineSeverity of Illness IndexOutcome (game theory)Disability EvaluationCognition0302 clinical medicineSociologyQuality of lifeSurveys and QuestionnairesMedicine and Health SciencesEthnicitiesPostoperative Periodlcsh:SciencePain Measurement030222 orthopedicsMultidisciplinaryMortality rateWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]ProfessionsAnterior surgerymedicine.anatomical_structureResearch DesignPreoperative PeriodCervical VertebraeFemaleResearch ArticleCervical vertebraemedicine.medical_specialtyPatientsDeath RatesDecision MakingSurgical and Invasive Medical ProceduresResearch and Analysis MethodsEducation03 medical and health sciencesPopulation MetricsPhysiciansSeverity of illnessmedicineHumansEducational AttainmentDemographyDutch PeopleSurvey ResearchPopulation Biologybusiness.industrylcsh:RBiology and Life SciencesPatient Outcome AssessmentHealth CareReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]ROC CurvePeople and PlacesQuality of LifePhysical therapyCognitive SciencePopulation Groupingslcsh:Qbusiness030217 neurology & neurosurgeryNeck Disability IndexNeuroscience
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One simple claudication question as first step in Peripheral Arterial Disease (PAD) screening: A meta-analysis of the association with reduced Ankle …

2019

Purpose and methods A meta-analysis using data from seven German population-based cohorts was performed by the German Epidemiological consortium of Peripheral Arterial Disease (GEPArD) to investigate whether one question about claudication is more efficient for PAD screening than established questionnaires. Claudication was defined on the basis of the answer to one question asking for pain in the leg during normal walking. This simple question was compared with established questionnaires, including the Edinburgh questionnaire. The associations of claudication with continuous ABI values and decreased ABI were analyzed by linear and logistic regression analysis, respectively. The results of t…

MaleQuestionnairesMedical DoctorsPhysiologyHealth Care ProvidersMedizinWalking030204 cardiovascular system & hematologyLogistic regressionVascular MedicineMathematical and Statistical TechniquesEndocrinology0302 clinical medicineSurveys and QuestionnairesEpidemiologyMedicine and Health SciencesMass ScreeningMedicineMedical Personnel030212 general & internal medicineMultidisciplinaryStatisticsQRMetaanalysisProfessionsmedicine.anatomical_structureResearch DesignMeta-analysisPhysical SciencesMedicineFemalemedicine.symptomResearch Articlemedicine.medical_specialtySilverEndocrine DisordersDeath RatesScienceResearch and Analysis MethodsSensitivity and SpecificityOddsPeripheral Arterial Disease03 medical and health sciencesSex FactorsPopulation MetricsGeneral PractitionersPhysiciansDiabetes mellitusInternal medicineDiabetes MellitusHumansAnkle Brachial IndexVascular Diseasesddc:610Statistical MethodsSurvey ResearchPopulation BiologyBiological Locomotionbusiness.industryBiology and Life SciencesOdds ratioIntermittent Claudicationmedicine.diseaseHealth CarePeripheral Vascular DiseaseMetabolic DisordersPeople and PlacesPopulation GroupingsAnklebusinessClaudicationMathematics
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Increased liver stiffness is associated with mortality in HIV/HCV coinfected subjects: The French nationwide ANRS CO13 HEPAVIH cohort study

2019

Background The association between liver stiffness measurements (LSM) and mortality has not been fully described. In particular the effect of LSM on all-cause mortality taking sustained virological response (SVR) into account needs further study. Methods HIV/HCV participants in the French nation-wide, prospective, multicenter ANRS CO13 HEPAVIH cohort, with ≥1 LSM by FibroScan (FS) and a detectable HCV RNA when the first valid FS was performed were included. Cox proportional hazards models with delayed entry were performed to determine factors associated with all-cause mortality. LSM and SVR were considered as time dependent covariates. Results 1,062 patients were included from 2005 to 2015 …

MaleRNA virusesSustained Virologic ResponseMetabolic disordersSocial SciencesHIV InfectionsHepacivirusmedicine.disease_causeGastroenterology0302 clinical medicineImmunodeficiency VirusesRisk FactorsPsychologyAlcohol consumptionProspective Studies030212 general & internal medicineProspective cohort studyPathology and laboratory medicineMultidisciplinaryDeath ratesCoinfectionHepatitis C virusMortality rateQHazard ratioRvirus diseasesHepatitis CMiddle AgedMedical microbiologyAddicts3. Good healthLiverDrug usersVirusesCohortElasticity Imaging TechniquesMedicineFemale030211 gastroenterology & hepatologyFrancePathogensResearch ArticleCohort studyAdultmedicine.medical_specialtyScienceHepatitis C virusLiver fibrosisAddictionGastroenterology and HepatologyAntiviral AgentsMicrobiology03 medical and health sciencesPopulation MetricsInternal medicineRetrovirusesmedicineHumansMortalityLiver diseasesProportional Hazards ModelsNutritionMedicine and health sciencesBiology and life sciencesFlavivirusesPopulation Biologybusiness.industryProportional hazards modelLentivirusOrganismsViral pathogensHIVHepatitis C Chronicmedicine.diseaseHepatitis virusesMicrobial pathogensDiet[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologiebusinessPLOS ONE
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Outcomes of Patients With Asymptomatic Aortic Stenosis Followed Up in Heart Valve Clinics

2018

International audience; Importance - The natural history and the management of patients with asymptomatic aortic stenosis (AS) have not been fully examined in the current era. Objective - To determine the clinical outcomes of patients with asymptomatic AS using data from the Heart Valve Clinic International Database. Design, setting, and participants - This registry was assembled by merging data from prospectively gathered institutional databases from 10 heart valve clinics in Europe, Canada, and the United States. Asymptomatic patients with an aortic valve area of 1.5 cm2 or less and preserved left ventricular ejection fraction (LVEF) greater than 50% at entry were considered for the prese…

MaleRegistrieUnited StateCanadamedicine.medical_specialty030204 cardiovascular system & hematologyAsymptomaticSudden deathDisease-Free Survival03 medical and health sciences0302 clinical medicineAortic valve replacementRetrospective StudieInternal medicinemedicineHumansProspective StudiesRegistries030212 general & internal medicineHeart valveWatchful WaitingProspective cohort studyRetrospective StudiesAgedAged 80 and overAsymptomatic DiseaseEjection fractionbusiness.industryDisease ManagementAortic Valve StenosisMiddle Agedmedicine.diseaseAortic Valve StenosiUnited States3. Good healthEuropeProspective StudieStenosisDeath Sudden Cardiacmedicine.anatomical_structureAortic valve stenosisAsymptomatic DiseasesCardiology[SDV.IB]Life Sciences [q-bio]/BioengineeringFemalemedicine.symptombusinessCardiology and Cardiovascular MedicineHuman
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Liver transplantation with grafts from septuagenarians.

2008

Abstract Background The purpose of this study was to evaluate our experience with orthotopic liver transplantation (OLT) using grafts from septuagenarians. Patients and Methods Seventeen adult patients underwent transplantation with grafts from donors 70 years of age or older during an 8-year period. Results The median donor age was 73 years (range, 70–83). Eleven (64.7%) donors had experienced at least 1 hypotensive period and received vasoactive drugs. Median cold and warm ischemia times were 7.25 hours and 35 minutes, respectively. Two recipients underwent retransplantation because of dysfunction or primary nonfunction. Morbidity rate was 47% and hospital mortality rate was 23.5%. After …

MaleReoperationmedicine.medical_specialtymedicine.medical_treatmentHospital mortalityLiver transplantationVasoactiveCause of DeathmedicineHumansHospital MortalitySurvival rateCause of deathAgedRetrospective StudiesAged 80 and overTransplantationbusiness.industryMortality rateRetrospective cohort studyTissue DonorsSurgeryLiver TransplantationTransplantationSurvival RateSurgeryFemalebusinessLiver FailureTransplantation proceedings
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Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic

2021

Association of Surgeons in Training Surgical Summit, online, 17 Oct 2020 - 17 Oct 2020 2021 Virtual Annual Meeting / Surgical Research Society, online, 24 Mar 2021 - 25 Mar 2021, National Research Collaborative Meeting, online, 10 Dec 2020 - 10 Dec 2020, Royal Australasian College of Surgeons Annual Academic Surgery Conference, online, 5 Nov 2020 - 5 Nov 2020; The British journal of surgery : BJS 108(12), 1448-1464 (2021). doi:10.1093/bjs/znab336

MaleRespiration Artificial/statistics & numerical dataSettore MED/18 - CHIRURGIA GENERALEeducation-Sciences du Vivant [q-bio]/Médecine humaine et pathologieAbdominal NeoplasmPostoperative Complications/mortalityNOsurgeryCohort Studies03 medical and health sciencesCOVID-19; death; SARS-CoV-2; surgery0302 clinical medicinePostoperative ComplicationsdeathHumans030212 general & internal medicinePandemicsAbdominal Neoplasms/surgeryAgedLS7_4COVID-19/mortalityRespiratory Distress SyndromePandemicSARS-CoV-2Respirationsurgical procedures operativemortalitysurgery specialtypandemicspulmonary complicationssars-cov-2covid-19coronavirus pandemicCOVID-19Middle Aged3126 Surgery anesthesiology intensive care radiologyRespiration Artificialsurgical proceduresoperativemortalitysurgery specialtypandemicspulmonary complicationssars-cov-2covid-19coronavirus pandemicAbdominal Neoplasms; Aged; COVID-19; Cohort Studies; Female; Humans; Male; Middle Aged; Pandemics; Postoperative Complications; Respiration Artificial; Respiratory Distress Syndrome; Elective Surgical ProceduresElective Surgical Procedures030220 oncology & carcinogenesisAbdominal NeoplasmsArtificialFemalePostoperative ComplicationCohort Studie[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyRespiratory Distress Syndrome/mortalityHuman
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Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 20…

2020

Artículo con numerosos autores. Sólo se hace referencia al primero que coincide con el de la UAM y al colectivo

MaleRespiratory diseasesRespiratory Tract DiseasesDiseaseChronic respiratory diseasesGlobal Burden of DiseasePulmonary Disease Chronic Obstructive0302 clinical medicineCost of Illness11. SustainabilityMETABOLIC RISKSEPIDEMIOLOGY030212 general & internal medicineChildCause of deathAged 80 and overCOPDDALYChronic obstructive pulmonary diseaseMortality rateRespiratory disease1. No povertyAge FactorsMiddle AgedDeath causes3. Good healthPREVALENCEHealth risksChild PreschoolCOMPARATIVE RISK-ASSESSMENTFemaledeath and disability worldwideQuality-Adjusted Life YearsTERRITORIESBURDENgrowth in absolute numbersPulmonary and Respiratory MedicineAdultADJUSTED LIFE-YEARSHealth burdensAdolescentMedicina195 COUNTRIESchronic respiratory diseasesArticle1117 Public Health and Health Services03 medical and health sciencesYoung AdultLife ExpectancySex FactorsBurden of Disease Respiratory diseaseSarcoidosis PulmonaryEnvironmental healthmedicineDisability-adjusted life yearHumansCOPDEXPOSURERisk factorMortalityAgedper-capita basisbusiness.industryDISABILITYInfant NewbornInfant1103 Clinical Sciencesasthmamedicine.diseaseAsthmaYears of potential life lost030228 respiratory systemRisk factors13. Climate actionSystematic analysesChronic DiseaseINJURIESHuman medicinePneumoconiosisMorbiditybusinessLung Diseases Interstitial1199 Other Medical and Health Sciences
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