Search results for "depletion."

Electric field-assisted proton transfer and water dissociation at the junction of a fixed-charge bipolar membrane

1998

Abstract Electric field-enhanced (EFE) water dissociation can occur at the interfacial space charge junction of both biological and synthetic fixed-charge bipolar membranes. This dissociation has so far been analysed on an electrochemical basis using modified second Wien effect and absolute rate theories. We propose a statistical thermodynamics model to describe the cooperative orientation of the water molecules by the electric field at the bipolar junction. The approach is simple and retains some of the essential aspects of the phenomenon. In particular, the EFE water dissociation can now be rationalised on the basis of a field-assisted proton transfer mechanism involving the membrane fixe…

Treatment of multiple sclerosis with rituximab: A multicentric Italian–Swiss experience

2020

Background: Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as an off-label treatment option for multiple sclerosis (MS). Objective: To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) and progressive MS. Methods: This is a multicenter, retrospective study on consecutive MS patients treated off-label with rituximab in 22 Italian and 1 Swiss MS centers. Relapse rate, time to first relapse, Expanded Disability Status Scale (EDSS) progression, incidence of adverse events, and radiological outcomes from 2009 to 2019 were analyzed. Results: A total of 355/451 enrolled subjects had at least one follow-up visit an…

Non-eosinophilic Airway Hyper-reactivity in Mice, Induced by IFN-γProducing CD4+and CD8+Lung T cells, is Responsive to Steroid Treatment

2014

Non-eosinophilic asthma is characterized by infiltration of neutrophils into the lung and variable responsiveness to glucocorticoids. The pathophysiological mechanisms have not been characterized in detail. Here, we present an experimental asthma model in mice associated with non-eosinophilic airway inflammation and airway hyper-responsiveness (AHR). For this, BALB/c mice were sensitized by biolistic DNA immunization with a plasmid encoding the model antigen β-galactosidase (pFascin-βGal mice). For comparison, eosinophilic airway inflammation was induced by subcutaneous injection of βGal protein (βGal mice). Intranasal challenge of mice in both groups induced AHR to a comparable extent as w…

Fermi-Dirac correlations in Lambda pairs in hadronic Z decays

2000

Two-particle correlations of Lambda Lambda and pairs have been studied in multihadronic Z decays recorded with the ALEPH detector at LEP in the years from 1992 to 1995. The correlations were measured as a function of the four-momentum difference Q of the pair. A depletion of events is observed in the region Q 2 GeV the fraction of pairs with spin one is consistent with the value of 0.75 expected for a statistical spin mixture, whilst for Q pairs, where no Fermi-Dirac correlations are expected, the spin one fraction is measured to be consistent with 0.75 over the entire analysed Q range. (C) 2000 Elsevier Science B.V. All rights reserved.

Diuretic Therapy in Old Patients

1984

The administration of diuretics is indicated in several clinical conditions characterized by more or less severe water and salt retention (congestive heart failure, non-compensated liver cirrhosis, renal syndromes etc.), or in cases in which water and sodium depletion is supposed to improve some pathophysiological aspects of clinical symptoms (e. g. as background treatment in arterial hypertension, or as emergency treatment in left ventricular failure.

CD34+ Cell Selection versus Reduced-Intensity Conditioning and Unmodified Grafts for Allogeneic Hematopoietic Cell Transplantation in Patients Age >5…

2018

Reduced-intensity conditioning (RIC) and T cell depletion (TCD) through CD34+ cell selection without the use of post-transplantation immunosuppression are 2 strategies used to reduce nonrelapse mortality (NRM) in older patients after allogeneic hematopoietic cell transplantation (allo-HCT). To compare the efficacy of the RIC and TCD approaches, we evaluated the outcomes of patients age >50 years with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) who underwent allo-HCT from an HLA-matched donor with one of these strategies. Baseline characteristics were comparable in the patients receiving TCD (n = 204) and those receiving RIC (n = 151), except for a higher proportion o…

Depletion of ozone and reservoir species of chlorine and nitrogen oxide in the lower Antarctic polar vortex measured from aircraft

2017

Novel airborne in situ measurements of inorganic chlorine, nitrogen oxide species, and ozone were performed inside the lower Antarctic polar vortex and at its edge in September 2012. We focus on one flight during the Transport and Composition of the LMS/Earth System Model Validation (TACTS/ESMVal) campaign with the German research aircraft HALO (High-Altitude LOng range research aircraft), reaching latitudes of 65°S and potential temperatures up to 405 K. Using the early winter correlations of reactive trace gases with N2O from the Atmospheric Chemistry Experiment-Fourier Transform Spectrometer (ACE-FTS), we find high depletion of chlorine reservoir gases up to ∼40% (0.8 ppbv) at 12 km to 1…

The effects of mental fatigue on sport-related performance

2018

International audience; Mental fatigue is known to increase subjective feelings of fatigue and to decrease cognitive performance, but its impact on physical performance remains poorly understood. The aim of this chapter was to review the results of 29 studies published between 2009 and April 2018 and focusing on the impact of mental fatigue on sport-related performance. Taken all studies together, it appears that mental fatigue impairs endurance performance, motor skills performance and decision-making performance. However, maximal force production is not reduced in the presence of mental fatigue. These observations suggest that mental fatigue impairs sport-related performance during exerci…

Do current levels of UV‐B radiation affect vegetation? The importance of long‐term experiments

2021

Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection.

2012

Abstract Regulatory T cells (Tregs) are important for the attenuation of immune reactions. During viral CNS infections, however, an indiscriminate maintenance of CNS immune privilege through Treg-mediated negative regulation could prevent autoimmune sequelae but impair the control of viral replication. We analyzed in this study the impact of Tregs on the development of acute viral encephalomyelitis, T cell-mediated antiviral protection, and prevention of CNS autoimmunity following intranasal infection with the gliatropic mouse hepatitis virus strain A59. To assess the contribution of Tregs in vivo, we specifically depleted CD4+Foxp3+ T cells in a diphtheria toxin-dependent manner. We found …