Search results for "depression."

Interoceptive Abilities in Inflammatory Bowel Diseases and Irritable Bowel Syndrome

2020

International audience; Alexithymia is usually described by three main dimensions difficulty identifying feelings (DIF), difficulty describing feelings (DDF), and externally oriented thinking (EOT). The most commonly used questionnaire investigating alexithymia, the Toronto Alexithymia Scale (TAS-20), supports this three-factor structure. One important assumption is that alexithymia severity is associated to vulnerability to somatic diseases, among them gastrointestinal disorders. However, the association between alexithymia and gastrointestinal disorders is not systematic, thus questioning the role of alexithymia as a vulnerability factor for those illnesses. A recent factor analysis sugge…

Evaluación de un programa psicoterapéutico para cuidadores de pacientes con TCA: Estudio piloto

2013

El estudio tuvo como objetivo comparar el nivel de discapacidad funcional, dolor y agotamiento, el autoconcepto-autoestima, y grandes dimensiones de personalidad, en personas con y sin fibromialgia (FM). El estudio se realizó con 190 participantes, 140 afectados de FM y 50 no afectados, entre 28 y 75 años (M= 52,16; DT= 9,18), 10 varones y 180 mujeres. Se utilizaron 4 instrumentos de evaluación para medir las variables objeto de estudio: impacto de la fibromialgia, autoconcepto, autoestima y personalidad. Los resultados evidenciaron que las personas con FM, comparadas con las que no están afectadas por esta enfermedad, tienen significativamente un nivel superior de discapacidad funcional, d…

Validity and reliability of electroencephalographic frontal alpha asymmetry and frontal midline theta as biomarkers for depression

2012

Electroencephalographic (EEG) frontal alpha asymmetry (FAA) and frontal midline (FM) theta have been suggested as biomarkers for depression and anxiety, but have mostly been assessed in small and non-clinical studies. In a clinical sample of 79 adults with depression (ICD-10: F32), resting EEG and scales of depression (MADRS) and anxiety (HADS-A) were measured at intake and after 3 months. FAA and FM theta values were referenced to a normative population database. Internal consistency, test-retest reliability, and correlations with psychiatric tests were examined. Reliability was sufficient. However, FAA and FM theta values were close to the general population, and correlations with psychia…

Effects of amsacrine (m-AMSA), a new aminoacridine antitumor drug, on the rabbit heart.

1983

There is emerging clinical evidence that amsacrine (m-AMSA) administration may be associated with cardiotoxic effects such as severe, even fatal, ventricular arrhythmias and impairment of the inotropic performance of the heart. Information on the cardiac effects of m-AMSA in animals is scanty. Studies on mice, dogs, and monkeys have not evidenced the cardiotoxicity of the compound. The data presented in this paper show that m-AMSA causes acute ECG alterations in normal rabbits and a dose-related negative inotropic effect on the isolated rabbit heart, suggesting that this species may be a useful model for the study of the cardiac actions of this antiblastic.

FGFR1-5-HT1A receptor heterocomplexes: relevance for neuroplasticity and depression

2014

Increased Stress Resistance and Lifespan in Chaenorhabditis elegans Wildtype and Knockout Mutants—Implications for Depression Treatment by Medicinal …

2021

Depression and anxiety disorders are widespread diseases, and they belong to the leading causes of disability and greatest burdens on healthcare systems worldwide. It is expected that the numbers will dramatically rise during the COVID-19 pandemic. Established medications are not sufficient to adequately treat depression and are not available for everyone. Plants from traditional medicine may be promising alternatives to treat depressive symptoms. The model organism Chaenorhabditis elegans was used to assess the stress reducing effects of methanol/dichlormethane extracts from plants used in traditional medicine. After initial screening for antioxidant activity, nine extracts were selected f…

The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2.

2021

Abstract Introduction Depression is one of the leading causes of death worldwide. Lower antioxidant concentrations and increased oxidative stress levels contribute to the development of depression. Effective and tolerable medications are urgently needed. Nrf2 and PRDX2 are promising targets in the treatment of oxidative stress and, therefore, promising for the development of novel antidepressants. Ursolic acid (UA), a natural triterpenoid found in various plants is known to exert neuroprotective and antioxidant effects. Skn-1 (which corresponds to human Nrf2) and prdx2 deficient mutants of the nematode Caenorhabditis elegans are suitable models to study the effect of UA on these targets. Ad…

Uztvertais sociālais atbalsts, apmierinātība ar partnerattiecībām un depresijas simptomi sievietēm 4 – 6 nedēļas pēc dzemdībām

2017

Pētījuma jautājumi, kuriem vēlos noskaidrot atbildes pētījumā rezultātā ir, kāda saistība pastāv starp uztverto sociālo atbalstu, apmierinātību ar partnerattiecībām un depresijas simptomiem sievietēm 4 – 6 nedēļas pēc dzemdībām. Otrs pētījuma jautājums ir noskaidrot, kā apmierinātība ar partnerattiecībām un uztvertais sociālais atbalsts prognozē depresijas simptomus sievietēm 4 – 6 nedēļas pēc dzemdībām. Pētījumā piedalījās 31 sieviete, kura bija 4 – 6 nedēļas pēc dzemdībām. Svarīgi nosacījumi bija, lai sievietei būtu piedzimis pirmais bērniņš un lai viņš būtu vesels, kas tika novērtēts pēc Apgares jaundzimušā veselības stāvokļa. Pētījumā tika izmantoti trīs pētījuma instrumenti. Lai noskai…

Inhibition by oxotremorine of acetylcholine resting release from guinea pig-ileum longitudinal muscle strips

1975

1. Longitudinal muscle strips of the guinea-pig ileum were incubated in Tyrode solution containing either DFP or physostigmine as cholinesterase inhibior. After a 90 min preincubation period the acetylcholine resting release into the medium was determined. Acetylcholine was estimated by gas chromatography. 2. The resting release was 0.39 nmol/g×min irrespective of the cholinesterase inhibitor used. In the presence of hexamethonium, or after omission of external calcium, the resting release fell by 50 and 55%, respectively. 3. Oxotremorine (10−5 and 10−4 M) significantly inhibited the resting release of acetylcholine by 25 and 33%, respectively. The inhibitory effect of oxotremorine was comp…

A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation

1969

1. The noradrenaline output from isolated rabbit hearts perfused with Tyrode solution was estimated fluorimetrically. The postganglionic sympathetic nerves of the heart were stimulated (10 shocks/sec; 1 msec) for three 1 min periods with intervals of 10 min. 2. The noradrenaline output evoked by 3 consecutive stimulation periods decreased exponentially. 3. Acetylcholine (10−9–10−6 g/ml) administered continuously one min before to one min after the second stimulation caused a dose-dependent reduction of the noradrenaline output evoked by the second stimulation to as low as 19% of the normal value. Acetylcholine in the concentrations applied did not cause a noradrenaline output by itself. 4. …