Search results for "depression."

2020

Objective: The suggested link between major depression disorder (MDD) and blood–brain barrier (BBB) alterations supports an impact on the neurovascular unit in this disease condition. Here we inves...

Impaired glucose regulation, depressive symptoms, and health-related quality of life

2020

IntroductionThis study aims to investigate whether the associations between impaired glucose regulation and health-related quality of life are modified by severity or type of depressive symptoms.Research design and methodsFor this cross-sectional study, we included 1939 individuals (mean age 61.5 years) from the Helsinki Birth Cohort Study. Between 2001 and 2004, a standard 2-hour 75 g oral glucose tolerance test was applied to define normoglycemia, pre-diabetes, and newly diagnosed diabetes. Information on previously diagnosed diabetes was collected from national registers and questionnaires. Pre-diabetes was defined as having either impaired fasting glucose or impaired glucose tolerance. …

A Neurovascular Blood–Brain Barrier In Vitro Model

2014

The cerebral microvasculature possesses certain cellular features that constitute the blood-brain barrier (BBB) (Abbott et al., Neurobiol Dis 37:13-25, 2010). This dynamic barrier separates the brain parenchyma from peripheral blood flow and is of tremendous clinical importance: for example, BBB breakdown as in stroke is associated with the development of brain edema (Rosenberg and Yang, Neurosurg Focus 22:E4, 2007), inflammation (Kuhlmann et al., Neurosci Lett 449:168-172, 2009; Coisne and Engelhardt, Antioxid Redox Signal 15:1285-1303, 2011), and increased mortality. In vivo, the BBB consists of brain endothelial cells (BEC) that are embedded within a precisely regulated environment conta…

Psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features-A systematic review of randomized clinical trials …

2021

Objectives To review the effectiveness of psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features. Methods We included randomized clinical trials on psychological therapies for adolescents with BPD and BPD features. Data were extracted and assessed for quality according to Cochrane guidelines, and summarized as mean difference (MD) with 95% confidence intervals (CI) for continuous data and as Odds ratios (OR) with 95% CI for dichotomous data. Risk of bias was assessed using Cochrane’s risk of bias tool for each domain. When possible, we pooled trials into meta-analyses, and used Trial Sequential Analysis (TSA) to control for random errors. Quality…

Pharmacotherapy, drug-drug interactions and potentially inappropriate medication in depressive disorders.

2021

Introduction The aim of this study was to describe the number and type of drugs used to treat depressive disorders in inpatient psychiatry and to analyse the determinants of potential drug-drug interactions (pDDI) and potentially inappropriate medication (PIM). Methods Our study was part of a larger pharmacovigilance project funded by the German Innovation Funds. It included all inpatients with a main diagnosis in the group of depressive episodes (F32, ICD-10) or recurrent depressive disorders (F33) discharged from eight psychiatric hospitals in Germany between 1 October 2017 and 30 September 2018 or between 1 January and 31 December 2019. Results The study included 14,418 inpatient cases.…

2014

Depressed patients frequently report a subjective slowing of the passage of time. However, experimental demonstrations of altered time perception in depressed patients are not conclusive. We added a timed action task (time-to-contact estimation, TTC) and compared this indirect time perception task to the more direct classical methods of verbal time estimation, time production, and time reproduction. In the TTC estimation task, the deviations of the estimates from the veridical values (relative errors) revealed no differences between depressed patients (n = 22) and healthy controls (n = 22). Neither did the relative errors of the TTC estimates differ between groups. There was a weak trend to…

Factors associated with stress when caring for a child with a short stature

2021

Short stature (SS) is one of the main diagnoses in Pediatric Endocrinology. SS can have a negative impact on family dynamics, causing stress and psychopathology. Poor adaptation by the family caregiver negatively affects the pedi- atric patient. Our objective was therefore to study the adjustment of the main family caregivers of pediatric patients with SS, analyzing the factors influencing it. One hundred and ten primary family caregivers of pediatric SS patients from hospitals in Valencia, Spain, participated. Parental stress (Pediatric Inventory for Parents), anxious and depres- sive symptoms (Hospital Anxiety and Depression Scale), family functioning (Family Cohesion and Adaptation Scale…

Inbreeding depression in the effects of body mass on energy use

2011

Large organisms have higher metabolic rates than small organisms but, if we compare their relative metabolic rates (i.e. per gram of tissue), this relationship is very often reversed. The pervasiveness of this phenomenon, called metabolic scaling, has attracted several theoretical explanations, and also produced lingering debate over whether metabolic scaling is a physically constrained and universally constant phenomenon or a more variable and evolutionarily malleable trait. To bring novel insights to this debate, we manipulated male Gryllodes sigillatus crickets’ coefficients of inbreeding to determine whether metabolic scaling is sensitive to the manipulation of genetic quality. Because …

Differential effects of faces and words in cognitive control in older adults with and without major depressive disorder: An emotional Stroop task stu…

2021

Aging and major depressive disorders have been associated with impaired cognitive control. These deficits are also influenced by the affective valence and by the type of stimulus processed. Using an emotional Stroop task, the current study aims to examine cognitive control deficits and their association with emotion regulation in depression and the influence of the type of stimulus (words and faces) in this association. A total of 26 older patients with a major depressive disorder (MDD) (19 women; age range: 65-84 years) and 26 older healthy controls (18 women; age range: 65-80 years) participated in the study. The results showed that MDD individuals presented greater Stroop effects than th…

Designing a framework for assisting depression severity assessment from facial image analysis

2015

Depression is one of the most common mental disorders affecting millions of people worldwide. Developing adjunct tools aiding depression assessment is expected to impact overall health outcomes and treatment cost reduction. To this end, platforms designed for automatic and non-invasive depression assessment could help in detecting signs of the disease on a regular basis, without requiring the physical presence of a mental health professional. Despite the different approaches that can be found in the literature, both in terms of methods and algorithms, a fully satisfactory system for the automatic assessment of depression severity has not been presented as yet. This paper describes a propose…