Search results for "depression"
showing 10 items of 1778 documents
Rapid and reliable genotyping procedure for detection of alleles with mutations, deletion, or/and duplication of the CYP2D6 gene
2009
Abstract Background Polymorphisms of cytochrome P450 2D6 (CYP2D6) have a significant effect on the pharmacokinetics of most tricyclic antidepressants. More than 150 alleles lead to four distinct phenotypes of drug metabolism. The phenotypes are described as ultrarapid, extensive, intermediate, and poor metabolizers. Therapeutic plasma levels of CYP2D6 substrates may be difficult to achieve. Here we describe a rapid and reliable procedure for CYP2D6*4, *3, *6, and *9 genotyping. Design and methods Serum concentrations of venlafaxine and its pharmacologically active metabolite, O-desmethylvenlafaxine, were measured in patients treated with the antidepressant venlafaxine, a substrate of CYP2D6…
Posttraumatic stress, depression and anxiety among adult long-term survivors of cancer in adolescence.
2010
Abstract Background To determine the prevalence of posttraumatic stress, depression and anxiety in adults who have survived cancer (⩾5 years) diagnosed in adolescence, as compared to healthy controls. Patients and methods Survivors (n = 820) of cancer during adolescence (age M = 30.4 ± 6.0 years; M = 13.7 ± 6.0 years since diagnosis) and 1027 matched controls without history of cancer (age M = 31.5 ± 6.9 years) completed standardised questionnaires measuring posttraumatic stress, depression and anxiety. Additionally, sub-groups of 202 survivors and 140 controls with elevated scores received structured interviews to ascertain DSM-IV-diagnoses. Results A total of 22.4% of the survivors report…
Decision making in a presumptive case of STEMI-like myocarditis
2015
In youngmales, differential diagnosis during chest pain is not always easy. When ECG findings suggest a cardiac origin of such symptoms, myo-pericarditis is usually themost likely hypothesis, beingmore common than Acute Coronary Syndromes (ACS) in the first decades of life [1]. In the presence of ST segment elevation, Troponin release and ventricular wall motion abnormalities, the diagnosis can be challenging, though. In the young a lowcoronary risk profile and atypical symptoms seldom support a working diagnosis of Coronary Heart Disease (CHD), and, therefore, urgent coronary angiography is not recommended routinely, although cases of early ACS are not so rare. In October 2014 a 26-year-ol…
A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression
2016
Abstract Background Recently there is increasing recognition of cognitive dysfunction as a core feature of Major Depressive Disorder (MDD). The goal of the current meta-analysis was to review and examine in detail the specific features of cognitive dysfunction in Melancholic (MEL) versus Non-Melancholic (NMEL) MDD. Methods An electronic literature search was performed to find studies comparing cognitive performance in MEL versus NMEL. A meta-analysis of broad cognitive domains ( processing speed , reasoning/problem solving , verbal learning , visual learning , attention/working memory ) was conducted on all included studies (n=9). Sensitivity and meta-regression analyses were also conducted…
LOW-RANK APPROXIMATION BASED NON-NEGATIVE MULTI-WAY ARRAY DECOMPOSITION ON EVENT-RELATED POTENTIALS
2014
Non-negative tensor factorization (NTF) has been successfully applied to analyze event-related potentials (ERPs), and shown superiority in terms of capturing multi-domain features. However, the time-frequency representation of ERPs by higher-order tensors are usually large-scale, which prevents the popularity of most tensor factorization algorithms. To overcome this issue, we introduce a non-negative canonical polyadic decomposition (NCPD) based on low-rank approximation (LRA) and hierarchical alternating least square (HALS) techniques. We applied NCPD (LRAHALS and benchmark HALS) and CPD to extract multi-domain features of a visual ERP. The features and components extracted by LRAHALS NCP…
Anxiety and depression among adult amputees: the role of attachment insecurity, coping strategies and social support.
2018
A number of studies have investigated the role of coping and social support as protective factors for psychosocial adjustment after amputation. In contrast, few have focused on the role of attachment styles. Therefore, the purpose of this study was to examine the relationship between attachment insecurity, social support, coping strategies and negative emotions, such as anxiety and depression, in adult amputees. Sixty-two amputated adults (71% males, 29% females), recruited from the Prosthetic Centre of the Italian Workers’ Compensation Authority, completed the Attachment Style Questionnaire, the Coping Inventory for Stressful Situations, the Multidimensional Scale of Perceived Social Suppo…
Factors Related to Women’s Psychological Distress during the COVID-19 Pandemic: Evidence from a Two-Wave Longitudinal Study
2021
Background. A growing body of research has highlighted the negative effects of the COVID-19 pandemic on women’s mental health. Previous studies showed that women have higher levels of depression, anxiety and PTSD, and worse psychological adjustment than men, which also persisted after the earlier phase of the pandemic. This study aimed to evaluate changes in women’s psychological distress during the pandemic and to evaluate the factors that have a more significant impact in predicting women’s psychological distress. Methods. This two-wave longitudinal study (T1 = Italian first lockdown, and T2 = second phase, when the restrictive measures were eased) involved 893 women (Mage = 36.45, SD = 1…
Relationship between sedentary behavior and depression: a mediation analysis of influential factors across the lifespan among 42,469 people in low- a…
2018
Abstract Background Sedentary behavior (SB) is associated with diabetes, cardiovascular disease and low mood. There is a paucity of multi-national research investigating SB and depression, particularly among low- and middle-income countries. This study investigated the association between SB and depression, and factors which influence this. Methods Cross-sectional data were analyzed from the World Health Organization's Study on Global Ageing and Adult Health. Depression was based on the Composite International Diagnostic Interview. The association between depression and SB (self-report) was estimated by multivariable linear and logistic regression analyses. Mediation analysis was used to id…
Approximal plaque and gingival sulcus bleeding in routine dental care patients: relations to life stress, somatization and depression.
2005
Objectives: Previous research on relations between life stress and periodontal conditions was often based on indicators of periodontal destruction history and stimulus-specific measures of life stress. The present study was undertaken to compare patients showing different degrees of gingival sulcus bleeding with patients without signs of bleeding, using an instrument measuring cognitive impacts of events and assessing reported symptoms of depression and somatization. Additionally the patient groups were compared with regard to dental status and dental visiting behaviour. Analog comparisons were conducted in patients with different degrees of approximal plaque. Materials and Methods: 140 rou…
A German Validation Study of the Inventory to Diagnose Depression
1989
The Inventory to Diagnose Depression (IDD), a self-rating scale designed to identify major depressive episodes (MDE) according to DSM-III, was validated in a sample of 83 inpatients. Depending whether the time criterion of MDE was included or omitted, 63 or 77 patients obtained a syndrome diagnosis of MDE established by means of a structured clinical interview (Polydiagnostic Interview) which served as yardstick. Sensitivity (84.1% with time criterion, 89.6% without time criterion), specificity (60%, 50%), predictive value (67.8%, 64.2%) and kappa (0.43, 0.29) were calculated and found to necessitate improvement for a reasonable application of the IDD in epidemiological and clinical setting…