Search results for "desmosoma"
showing 4 items of 4 documents
Contactus adherens, a special type of plaque-bearing adhering junction containing M-cadherin, in the granule cell layer of the cerebellar glomerulus.
1995
In the glomeruli of the granule cell layer of mammalian cerebellum, neuronal extensions are interconnected by numerous small, nearly isodiametric (diameters up to 0.1 micron), junctions previously classified as puncta adherentia related to the vinculin-containing, actin microfilament-anchoring junctions of the zonula adherens of epithelial and certain other cells. Using immunofluorescence and immunoelectron microscopy, we have found, however, that these junctions are negative for E- and VE-cadherin, for desmosomal cadherins, and also for vinculin, alpha-actinin, and desmoplakin, but they do contain, in addition to the protein plakoglobin common to all forms of adhering junctions, the plaque…
Desmosomes: interconnected calcium-dependent structures of remarkable stability with significant integral membrane protein turnover
2002
Desmosomes are prominent cell adhesion structures that are major stabilizing elements, together with the attached cytoskeletal intermediate filament network, of the cytokeratin type in epithelial tissues. To examine desmosome dynamics in tightly coupled cells and in situations of decreased adhesion, fluorescent desmosomal cadherin desmocollin 2a (Dsc2a) chimeras were stably expressed in human hepatocellular carcinoma-derived PLC cells (clone PDc-13) and in Madin-Darby canine kidney cells (clone MDc-2) for the continuous monitoring of desmosomes in living cells. The hybrid polypeptides integrated specifically and without disturbance into normal-appearing desmosomes that occurred in associati…
Structure and Function of Desmosomes
2007
Desmosomes are prominent adhesion sites that are tightly associated with the cytoplasmic intermediate filament cytoskeleton providing mechanical stability in epithelia and also in several nonepithelial tissues such as cardiac muscle and meninges. They are unique in terms of ultrastructural appearance and molecular composition with cell type-specific variations. The dynamic assembly properties of desmosomes are important prerequisites for the acquisition and maintenance of tissue homeostasis. Disturbance of this equilibrium therefore not only compromises mechanical resilience but also affects many other tissue functions as becomes evident in various experimental scenarios and multiple diseas…
Bases fisiopatológicas y moleculares de la miocardiopatía arritmogénica en un modelo de ratón para placofilina-2 truncada
2016
La miocardiopatía arritmogénica (MCA) es una enfermedad cardíaca degenerativa caracterizada por el remplazo de tejido cardíaco por tejido fibro-adiposo, la progresiva dilatación y disfunción del ventrículo derecho y la aparición de arritmias. Aunque es considerada una enfermedad rara, la MCA es una importante causa de muerte súbita cardíaca (MSC) entre personas jóvenes (<35 años). Además, su incidencia es hasta 5 veces mayor entre atletas, lo que sugiere que el ejercicio intensivo es un factor de riesgo importante en el desarrollo de la enfermedad. La MCA es una patología familiar en, al menos, un 50% de los casos, lo que demuestra su carácter hereditario. De hecho, mutaciones en todos los …