Search results for "determinant"
showing 10 items of 377 documents
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
2016
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation o…
Sex-Specific Genetic Effects Associated with Pigmentation, Sensitivity to Sunlight, And Melanoma in a Population of Spanish Origin
2016
Background Human pigmentation is a polygenic quantitative trait with high heritability. In addition to genetic factors, it has been shown that pigmentation can be modulated by oestrogens and androgens via up- or down-regulation of melanin synthesis. Our aim was to identify possible sex differences in pigmentation phenotype as well as in melanoma association in a melanoma case-control population of Spanish origin. Methods Five hundred and ninety-nine females (316 melanoma cases and 283 controls) and 458 males (234 melanoma cases and 224 controls) were analysed. We genotyped 363 polymorphisms (single nucleotide polymorphisms (SNPs)) from 65 pigmentation gene regions. Results When samples were…
2021
A substantial body of research has shown worse health conditions for East- vs. West-Germany in the wake of reunification. In the present study, we investigate how these differences between the two formerly divided regions developed and what maintains them. Specifically, we consider the associations between health status, income satisfaction, and health-related locus of control. In a quasi-experimental and longitudinal study design, we are particularly interested in the differences between individuals who stayed in East-Germany and those who were born in the East but migrated to West-Germany. To this end, we examined data from seven waves of the Saxony Longitudinal Study (2003–2009). Specifi…
Evaluación participativa del territorio con enfoque de equidad: adaptación y validación de la Place Standard al contexto español
2022
OBJECTIVE Translation and cross-cultural adaptation to the Spanish context of the Place Standard tool to undertake participatory evaluations in place-based communities. METHOD A back-translation method was used to obtain an adapted version of the original Place Standard tool. The translated version was reviewed by a multidisciplinary committee of experts and validated using the Delphi method. RESULTS The final version of the adapted Place Standards tool (Entornos de Vida in Spanish) consists of 14 dimensions and 99 items. 21% of the items presented semantic difficulties during the translation. Total consensus through the Delphi panel was reached on 72% of the items. The analysis resulted in…
Le social à l’épreuve, l’épreuve du social. Ou l'art d'accommoder la position sociale des patients dans le travail préventif en médecine générale
2021
Resume Objectif Cet article interroge la maniere dont les medecins generalistes liberaux prennent en compte la position sociale de leurs patients dans leur travail preventif. Methode Apres une revue des principales constructions normatives censees equiper les generalistes pour l’apprehension des dimensions sociales, l’article utilise deux enquetes sur la dispensation des soins preventifs, l’une epidemiologique (PrevQuanti) et l’autre sociologique (PrevQuali). Resultats La deontologie, la formation et les recommandations mettent difficilement en forme les dimensions sociales de la sante avec lesquelles doivent composer les generalistes. L’enquete PrevQuanti a pourtant mis en evidence que la …
Social determinants of identity in communities: A social capital- and social categorization-based approach – findings from Latvia
2017
The article investigates the relations, in the light of new paradigms of economic development, between trust and economic wealth at the micro level in the Republic of Latvia, by means of a structural equation modelling-based approach and a framework combining social capital and social identity theory, in a rationale of cross-fertilization between social and cognitive science. Results are also tested against control dimensions reflecting relevant divides in Latvian society (residence place dimensions; ethno-linguistic belongings; educational differences). General results support the hypothesis of the existence of a causal path connecting personal wealth, institutional trust, social engagemen…
From particular polynomials to rational solutions to the PII equation
2022
The Painlevé equations were derived by Painlevé and Gambier in the years 1895 − 1910. Given a rational function R in w, w ′ and analytic in z, they searched what were the second order ordinary differential equations of the form w ′′ = R(z, w, w ′) with the properties that the singularities other than poles of any solution or this equation depend on the equation only and not of the constants of integration. They proved that there are fifty equations of this type, and the Painlevé II is one of these. Here, we construct solutions to the Painlevé II equation (PII) from particular polynomials. We obtain rational solutions written as a derivative with respect to the variable x of a logarithm of a…
El Derecho al disfrute del más alto nivel posible de salud en las políticas contra el tabaquismo
2020
El esfuerzo internacional para el control del tabaco incorporó el marco de los derechos humanos de forma tardía y -paradójicamente- después de que los derechos se alegaran frente a las medidas antitabaco. A pesar de lo avanzado, el marco de derechos humanos todavía tiene potencialidades por explorar en este ámbito. Así, cabría pensar en un uso no defensivo sino proactivo de los derechos, especialmente para la protección de grupos especialmente vulnerables. Además, combinado con el marco de los determinantes sociales de la salud, habría que afrontar que, en diferentes contextos, la mortalidad y morbilidad asociada al tabaco se reparte de forma inequitativa. International efforts for tobacco …
Una aproximación a la perspectiva de género en drogodependencias y VIH/SIDA
2002
En el presente trabajo se aborda la necesidad de integrar el concepto de genero como un factor a considerar en la problemática de las drogodependencias y VIH/Sida. El contenido de este concepto esta basado en el carácter relacional Hombre/mujer Se aportan datos acerca de la situación epidemiológica, así como factores relevantes y problemas específicos a partir de estudios realizados en todo el mundo, pero haciendo especial énfasis en las zonas no desarrolladas, donde el impacto de la pobreza es un fuerte potenciador del VlH/Sida y drogas. Se reseñan algunos esfuerzos por abordar la perspectiva de género como el programa de Igualdad de Oportunidades entre hombres y mujeres de la Unión Europe…
Sexual disorders and dyspnoea among women with obstructive sleep apnea
2020
Abstract Purpose We aimed to assess sexual function, sexual distress and the prevalence of female sexual dysfunction (FSD) among women with obstructive sleep apnea syndrome (OSA), and to assess if the presence of OSA and dyspnea influences the prevalence of FSD, body image during sexual activity and sexual function. Methods We assessed 23 women with new OSA diagnosis and 23 healthy age and body mass index (BMI) matched controls. Sexual functions were evaluated by Changes in Sexual Functioning Questionnaire (CSFQ), sexual dysfunction was diagnosed based on DSM-5 criteria during the semi-structured sexual interview, whereas body image was evaluated by Body Exposure during Sexual Activities Qu…