Search results for "determination"

The Protein Structure Context of PolyQ Regions.

2016

Proteins containing glutamine repeats (polyQ) are known to be structurally unstable. Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to neurodegenerative disease, a symptom of which are protein aggregates. This has led to extensive research of the structure of polyQ stretches. However, the accumulation of contradictory results suggests that protein context might be of importance. Here we aimed to evaluate the structural context of polyQ regions in proteins by analysing the secondary structure of polyQ proteins and their homologs. The results revealed that the secondary structure in polyQ vicinity is predominantly random coil or helix. Importantly, the region…

Physical and cognitive doping in university students using the unrelated question model (UQM): Assessing the influence of the probability of receivin…

2018

Study objectives: In order to increase the value of randomized response techniques (RRTs) as tools for studying sensitive issues, the present study investigated whether the prevalence estimate for a sensitive item π̂$_{s}$ assessed with the unrelated questionnaire method (UQM) is influenced by changing the probability of receiving the sensitive question p. Material and methods: A short paper-and-pencil questionnaire was distributed to 1.243 university students assessing the 12-month prevalence of physical and cognitive doping using two versions of the UQM with different probabilities for receiving the sensitive question (p ≈ 1/3 and p ≈ 2/3). Likelihood ratio tests were used to assess wheth…

Indirect Quantitative Determination of Organolithium Compounds by Gas Chromatography

1976

Polymere acroleine. III. Mittteilung. Oximierung und quantitative Bestimmung der Aldehydgruppen

1956

Die Oximierung von Disacryl wird beschrieben. Ferner werden Bedingungen fur eine quantitative Bestimmung von Aldehydgruppen in polymeren Acroleinen mitgeteilt. Es wird festgestellt, das Disacryl und ein durch Redox-Polymerisation gewonnenes Polyacrolein etwa 65% reaktionsfahige Aldehydgruppen enthalten. Bei Polyacroleinen, die mittels Borfluorid-Atherat oder Kaliumcarbonat gewonnen wurden, betragt der Umsatz mit Hydroxylamin nur etwa 20% d. Th. The oximation reaction of disacryl is described. The conditions of a quantitative determination of aldehyde function in polymeric acroleins have been investigated. It has been shown, that disacryl and an other polyacrolein, prepared by a redox-polyme…

Sample size planning of two-arm superiority and noninferiority survival studies with discrete follow-up

2016

In clinical trials using lifetime as primary outcome variable, it is more the rule than the exception that even for patients who are failing in the course of the study, survival time does not become known exactly since follow-up takes place according to a restricted schedule with fixed, possibly long intervals between successive visits. In practice, the discreteness of the data obtained under such circumstances is plainly ignored both in data analysis and in sample size planning of survival time studies. As a framework for analyzing the impact of making no difference between continuous and discrete recording of failure times, we use a scenario in which the partially observed times are assig…

Caries prevalence in children from Valencia (Spain) using ICDAS II criteria, 2010

2014

Objectives: To assess the oral health status of the child population and its evolution over the 2004-2010 period. Study Design: A descriptive cross-sectional study of the entire schoolchild population of the Valencia region of Spain was conducted using cluster sampling. Seventy schools were selected. The sample size was 1373 pupils, aged 6, 12 and 15 years. The children were examined in November and December 2010, at their schools, by 6 examiners calibrated in the ICDAS II method. The descriptive statistics, comparison of means and comparison of proportions (p0) was 30% in primary dentition at 6 years and 37.7% and 43.6% in permanent dentition at 12 and 15 years respectively. At 6, 12 and 1…

Addition of either pioglitazone or a sulfonylurea in type 2 diabetic patients inadequately controlled with metformin alone: impact on cardiovascular …

2012

Abstract Background and aims Metformin is the first-line therapy in type 2 diabetes. In patients inadequately controlled with metformin, the addition of a sulfonylurea or pioglitazone are equally plausible options to improve glycemic control. However, these drugs have profound differences in their mechanism of action, side effects, and impact on cardiovascular risk factors. A formal comparison of these two therapies in terms of cardiovascular morbidity and mortality is lacking. The TOSCA.IT study was designed to explore the effects of adding pioglitazone or a sulfonylurea on cardiovascular events in type 2 diabetic patients inadequately controlled with metformin. Methods Multicentre, random…

La Valle dei Templi in epoca medioevale. Caratterizzazione antropologica e paleopatologica delle sepolture antistanti in Tempio della Concordia

2021

Riassunto ― Il lavoro presenta i risultati delle analisi bio-archeologiche effettuate su resti scheletrici umani rinvenuti in quattordici sepolture di epoca medioevale rinvenute nel Parco Archeologico della Valle dei Templi di Agrigento (Sicilia). L’obiettivo è stato l’acquisizione delle informazioni necessarie per la ricostruzione del profilo biologico di ciascun individuo, al fine di determinarne il sesso, la stima dell’età biologica alla morte, la stima della statura e la valutazione delle patologie e degli indicatori di stress occupazionale mediante le correnti metodologie e tecniche diagnostiche di tipo antropologico. Sebbene il cattivo stato di conservazione di alcuni individui non ne…

A New Multinomial Accuracy Measure for Polling Bias

2014

In this article, we propose a polling accuracy measure for multi-party elections based on a generalization of Martin, Traugott, and Kennedy's two-party predictive accuracy index. Treating polls as random samples of a voting population, we first estimate an intercept only multinomial logit model to provide proportionate odds measures of each party's share of the vote, and thereby both unweighted and weighted averages of these values as a summary index for poll accuracy. We then propose measures for significance testing, and run a series of simulations to assess possible bias from the resulting folded normal distribution across different sample sizes, finding that bias is small even for polls…

Effectiveness of lingual versus labial fixed appliances in adults according to the Peer Assessment Rating index.

2019

Introduction: The purpose of this study was to compare the effectiveness of lingual treatment and labial fixed appliances in the treatment of adult orthodontic patients. Methods: We conducted a retrospective study of 72 patients. The Peer Assessment Rating (PAR) index was measured at the start (T0) and end (T1) of treatment. Significant differences between treatment means were determined by means of analysis of variancewith the Bonferroni correction or with the use of Fisher exact test. Results: The lingual group had a mean pretreatment age of 28.6 ± 6.7 years, and the labial group had a pretreatment age of 26.6 ± 9.5 years. This difference was statistically not significant. The mean pre- a…