Search results for "development"
showing 10 items of 26949 documents
Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea
2019
Background: Thyroid cancer has become the most common cancer in Korea. Generally, thyroid cancer patients have a good prognosis; however, 15–20% of patients experience recurrence or distant metastasis or are refractory to standard treatment. We assessed the safety of sorafenib and lenvatinib in patients with advanced or metastatic radioactive iodine-refractory differentiated thyroid cancers (DTC) consecutively treated at a tertiary center in South Korea.Methods: We retrospectively reviewed the charts of all consecutive patients with DTC treated during ≥6 months with lenvatinib (February 2016–April 2018) and sorafenib (January 2014–April 2018) at Gangnam Severance Hospital. Patients were tre…
Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study
2016
Purpose The PRAME tumour antigen is expressed in several tumour types but in few normal adult tissues. A dose-escalation phase I/II study (NCT01149343) assessed the safety, immunogenicity and clinical activity of the PRAME immunotherapeutic (recombinant PRAME protein (recPRAME) with the AS15 immunostimulant) in patients with advanced melanoma. Here, we report the phase I dose-escalation study segment. Patients and methods Patients with stage IV PRAME-positive melanoma were enrolled to 3 consecutive cohorts to receive up to 24 intramuscular injections of the PRAME immunotherapeutic. The RecPRAME dose was 20, 100 or 500 µg in cohorts 1, 2 and 3, respectively, with a fixed dose of AS15. Advers…
A sustainable city environment through child safety and mobility:A challenge based on ITS?
2012
Our cities should be designed to accommodate everybody, including children. We will not move toward a more sustainable society unless we accept that children are people with transportation needs, and ‘bussing’ them around, or providing parental limousine services at all times, will not lead to sustainability. Rather, we will need to make our cities walkable for children, at least those above a certain age. Safety has two main aspects, traffic safety and personal safety (risk of assault). Besides being safe, children will also need an urban environment with reasonable mobility, where they themselves can reach destinations with reasonable effort; else they will still need to be driven. This p…
Why Did They Leave School? A Self Determination Theory Perspective into Narratives of Finnish Early School Leavers
2021
The present study aims to provide insights into the experiences of early school leavers within the Finnish context. We conducted a narrative inquiry among eleven early school leavers who were in prison when they were interviewed. Self Determination Theory (SDT), more specifically the concept of frustration of the three basic psychological needs of competence, relatedness and autonomy, and the tendency of people to move towards more supporting environments, was used as an interpretative tool, along with contextual information. We identified three pathways out of school, differing in the locus of need thwarting circumstances and the availability of access to transfer into a more satisfying en…
SIA “Apranga SLV” saimnieciskās darbības analīze un tālākās attīstības iespējas
2019
Maģistra darba tēma ir SIA “Apranga SLV” saimnieciskās darbības analīze un tālākās attīstības iespējas. Darba mērķis ir izanalizēt SIA “Apranga SLV” saimniecisko darbību un izstrādāt priekšlikumus turpmākai uzņēmuma attīstībai. Maģistra darba pirmajā daļā autore veic mazumtirdzniecības nozares analīzi. Otrajā daļā apraksta saimnieciskās darbības teorētisko raksturojumu. Trešajā daļā autore veic saimnieciskās darbības novērtējumu Stradivarius, izpētot uzņēmuma ekonomisko informāciju. Ceturtajā daļā autore novērtē Stradivarius saimnieciskās darbības rādītājus, salīdzinot ar citiem uzņēmumiem un nozares vidējiem rādītājiem. Darba beigās tiek izstrādāti secinājumi un priekšlikumi. Maģistra darb…
Toward a contextualized understanding of inside sales: the role of sales development in effective lead funnel management
2022
Purpose The purpose of this study is to provide a contextualized understanding of how business-to-business (B2B) firms use the sales development function for efficient and effective lead funnel management. Design/methodology/approach The authors adopted a qualitative field-study approach and interviewed 13 people from eight firms. While software as a service (SaaS) firms are the most prevalent application context for the sales development function, the authors also included respondents from non-SaaS firms to develop an in-depth understanding of the contextualized nature of the sales development process. Findings Sales development processes can be applied in outbound prospect-focused, outbo…
Floorball as a new sport : case study : Bulgaria as a floorball destination from insider's point of view
2011
Floorball is a relatively new but quickly growing sport. Together with its development and spreading its importance grows as well. However previously conducted research on floorball from its managerial point of view is rare, especially on an international scale. The present investigation makes an attempt to fill this gap in a holistic manner. It explores the research problem of finding the potentials of floorball as a sustainably successful sport – worldwide and in the case country, Bulgaria.
The effectiveness of personalized design to feed elderly people
2015
Beyond the physiological age, the elderly population is characterized by a high heterogeneity in terms of physical, psychological and sociological status (Maître et al, 2015). Regarding eating behavior, several studies have highlighted a large inter-individual variability in chemosensory abilities (i.e. the ability to perceive an odor or a taste; Sulmont-Rossé et al, 2015) and oral-heath status (i.e. dental status, salivary flow; ALIMASSENS project), as well as inter-individual variability in food preference and food intake (AUPALESENS project). However, the food offer dedicated to the elderly population, and in particular to elderly people who needs help to obtain and/or prepare food for t…
A New Development in Online Marketing: Introducing Digital Inbound Marketing
2015
This paper addresses the conceptualization, scale development and scale validation related to the study of consumer engagement in online settings. It first reviews this concept and draws attention to the multidimensionality of the construct, considering the underlying cognitive, emotional, and behavioral dimensions of consumer engagement. Then, it presents the foundation of this concept in relationship marketing and adds support to this proposition. Further, it proposes the construction and psychometric assessment of a 37 scales that examine all three dimensions, based on an international sample of 110 respondents who engage with a brand on a social media network. Based on multiple and succ…
Autism spectrum disorder and schizophrenia – similarities between the two disorders with a case report of a patient with dual diagnosis
2023
This paper presents the genetic, molecular and neuroanatomical similarities between autism spectrum disorder (ASD) and schizophrenia using the case report of a 34-year-old female patient with a previous diagnosis of schizophrenia as an example. As a result of repeat hospitalization, expanded history, psychological testing and verification of persistent symptoms of psychopathology, a cooccurring diagnosis of autism spectrum disorder was made.