Search results for "development"
showing 10 items of 26949 documents
Gadolinium toxicity on sea urchin embryos of geographically and phylogenetically distant species
2016
Pharmaceuticals are a class of emerging environmental contaminants. Gadolinium (Gd) is a metal of the lanthanide series of the elements whose chelates are commonly employed as contrast agents for magnetic resonance imaging, and subsequently released into the aquatic environment. We investigated the consequences of sea urchin embryo exposure to sublethal Gd concentrations, comparing the effects on the development of four phylogenetically and geographically distant species: two Mediterranean species, Paracentrotus lividus and Arbacia lixula, and two species living in the East coast of Australia, Heliocidaris tuberculata and Centrostephanus rodgersii. Measures of the Gd and Ca content inside e…
Umiejętności i wiedza politechniczna uczniów w młodszym wieku szkolnym
2013
Projektowanie i realizacja edukacji technicznej w klasach I-III
2020
Dynamiczny rozwój nauki i techniki będący synonimem dzisiejszej cywilizacji stawia przed współczesnym systemem szkolnictwa wyzwania dotyczące działań preparacyjnych mających na celu ugruntowanie wiedzy i kultury politechnicznej ucznia. Rozwój techniki umożliwił człowiekowi zmienianie swego otoczenia oraz warunków życia. Obok nauki i sztuki, coraz wyraźniej wpływa ona na całokształt życia i stanowi bardziej znaczący wskaźnik kultury technicznej współczesnego człowieka i społeczeństwa.
The role of adolescents' temperament in their positive and negative emotions as well as in psychophysiological reactions during achievement situations
2019
Abstract This study examined the role of adolescents' (n = 190) temperament in their emotional reactions in achievement situations. Adolescents rated their temperament (i.e., surgency/extraversion, negative affectivity, effortful control) and completed achievement tasks in Grade 6. They also reported their emotions before and during challenging and non-challenging tasks. In addition, adolescents' autonomic nervous system reactions (i.e., skin conductance levels) were recorded. The results showed that high effortful control was related to higher levels of positive emotions independent of the degree of task difficulty. Low negative affectivity and high effortful control were related to lower …
Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals
2021
This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used…
Skin Immunomodulation during Regeneration: Emerging New Targets
2021
Adipose-Derived Stem Cells (ADSC) are present within the hypodermis and are also expected to play a pivotal role in wound healing, immunomodulation, and rejuvenation activities. They orchestrate, through their exosome, the mechanisms associated to cell differentiation, proliferation, and cell migration by upregulating genes implicated in different functions including skin barrier, immunomodulation, cell proliferation, and epidermal regeneration. ADSCs directly interact with their microenvironment and specifically the immune cells, including macrophages and T and B cells, resulting in differential inflammatory and anti-inflammatory mechanisms impacting, in return, ADSCs microenvironment and …
Maturation of Epidermal Langerhans Cells In Vitro Is Accompanied by Downregulation of 4F2 (CD98) as Determined by Differential Display
1998
Following short-term culture, Langerhans cells mature morphologically and functionally into potent immunostimulatory cells. As regulation of gene expression accompanies this maturation process, it is likely that differentially expressed genes are involved in the maturation events. Using the recently described method of differential display, we generated cDNA expression patterns starting with mRNA of murine epidermal Langerhans cells isolated either directly (fLC) or following 3 d cultivation (cLC). Five hundred putative differentially expressed cDNA fragments were recovered from the gel. For a part of the fragments differential expression was confirmed by dot blot and Southern hybridization…
Microneedle-Based Delivery: An Overview of Current Applications and Trends
2020
Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the stratum corneum, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the …
Facilitating leadership team communication
2015
The purpose of this study is to understand and describe how to facilitate competent communication in leadership teamwork. Grounded in the premises of social constructionism and informed by such theoretical frameworks as coordinated management of meaning theory (CMM), dialogic organization development (OD), systemic-constructionist leadership, communication competence, and reflexivity, this study seeks to produce further insights into understanding leadership team communication, communication competence, and team facilitation as applied communication research. This study consists of five articles. The first focuses on the theoretical framing of the relationality of communication competence i…