Search results for "developmental neuroscience"
showing 10 items of 360 documents
Spin as Primordial Self-Referential Process Driving Quantum Mechanics, Spacetime Dynamics and Consciousness
2007
We have recently theorized that consciousness is intrinsically connected to quantum mechanical spin since said spin is embedded in the microscopic structure of spacetime and is more fundamental than spacetime itself, that is, spin is the “mind-pixel.” Applying these ideas to the particular structures and dynamics of the brain, we have developed a qualitative model of quantum consciousness. In this paper, we express our fundamental view that spin is a primordial self-referential process driving quantum mechanics, spacetime dynamics and consciousness. To justify such a view, we will draw support from existing literatures, discuss from a reductionist perspective the essential properties said s…
Maternal pre- and postnatal mental health trajectories and child mental health and development
2011
Pregnancy and early motherhood involve uncertainty and change, which can evoke mental health problems. We identified maternal mental health trajectories in pre- and postnatal period, and examined their association with later child mental health and development. Finnish mothers reported psychological distress (General Health Questionnaire [GHQ-36]) and depressive (Beck Depression Inventory [BDI-13]) symptoms in pregnancy (T1; N = 788) and two months (T2; N = 657) and 12 months (T3; N = 545) postpartum. Both parents accounted their child’s mental health (Behavior Assessment System for Children [BASC]) and social (Social Skills Rating System [SSRS], Child Behavior Scale [CBS]) and cognitive d…
P4–286: Secretion of the soluble APP ectodomain (APPS) is not affected by the non–steroidal anti–inflammatory drugs ibuprofen and indomethacin in pri…
2006
Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126).
1997
Flupirtine, trade name Katadolon, is a centrally acting nonopioid analgesic that has recently been found to display cytoprotective activity in vitro and in vivo on neurons induced to undergo apoptosis. This report shows that the PrP106-126 fragment of the prion protein, which is the likely etiological agent for a series of encephalopathies, is toxic to cortical neurons in vitro. Simultaneously, PrP106-126 influences the molecular GSH content and the bcl-2 expression in neurons. Significant toxicity (32% reduction in cell viability) was observed at a concentration of 50 microM of the peptide after 9 days of incubation, while at higher concentrations toxicity increased to 70%. Neurotoxicity w…