Search results for "diabètes"

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Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes.

2015

International audience; Diabetes is a chronic metabolic disease with a high prevalence worldwide. Diabetes and insulin resistance are associated with the development of cardiovascular and nervous diseases. The development of these disorders reflects complex pathological processes in which the oxidative stress caused by reactive oxygen species (ROS) and reactive nitrogen species (RNS) plays a pivotal role. It is widely accepted that diabetes impairs endothelial nitric oxide synthase (eNOS) activity and increases the production of ROS, thus resulting in diminished NO bioavailability and increased oxidative stress. Alpha-lipoic acid (LA) possesses beneficial effects both in the prevention and …

antioxidantdiabètesAntioxidantPhysiologymedicine.medical_treatmentAlpha-Lipoic Acidmedicine.disease_causeAntioxidantschemistry.chemical_compound0302 clinical medicineprevention0303 health sciencesdiabetestreatmentThioctic AcidGeneral MedicineReactive Nitrogen Species[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system3. Good healthMitochondriapréventionLipoic acid030220 oncology & carcinogenesismedicine.medical_specialtyBiologytraitement03 medical and health sciencesInsulin resistanceantioxydant[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemDihydrolipoic acidPhysiology (medical)Internal medicineDiabetes mellitusmedicineDiabetes Mellitusacide lipoïqueAnimalsHumansmétabolismeReactive nitrogen species030304 developmental biologyPharmacologylipoic acidmedicine.diseaseOxidative StressEndocrinologychemistryReactive Oxygen SpeciesmetabolismOxidative stressCanadian journal of physiology and pharmacology

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
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LSLife Sciences
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SHSocial Sciences and Humanities
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