Search results for "dicarboxylic acid"
showing 10 items of 75 documents
CCDC 241330: Experimental Crystal Structure Determination
2005
Related Article: M.Brunner, M.Nissinen, T.Straub, K.Rissanen, A.M.P.Koskinen|2005|J.Mol.Struct.|734|177|doi:10.1016/j.molstruc.2004.09.020
CCDC 1025299: Experimental Crystal Structure Determination
2015
Related Article: Carolina Pejo, Guilherme P. Guedes, Miguel A. Novak, Nivaldo L. Speziali, Raúl Chiozzone, Miguel Julve, Francesc Lloret, Maria G. F. Vaz, Ricardo González|2015|Chem.-Eur.J.|21|8696|doi:10.1002/chem.201500168
CCDC 1025298: Experimental Crystal Structure Determination
2015
Related Article: Carolina Pejo, Guilherme P. Guedes, Miguel A. Novak, Nivaldo L. Speziali, Raúl Chiozzone, Miguel Julve, Francesc Lloret, Maria G. F. Vaz, Ricardo González|2015|Chem.-Eur.J.|21|8696|doi:10.1002/chem.201500168
CCDC 173785: Experimental Crystal Structure Determination
2004
Related Article: A.M.Costero, J.P.Villarroya, S.Gil, P.Gavina, M.C.R.De Arellano|2003|Supramol.Chem.|15|403|doi:10.1080/1061027031000116001
CCDC 171929: Experimental Crystal Structure Determination
2001
Related Article: M.J.Plater, M.R.St.J.Foreman, R.A.Howie, J.M.S.Skakle, E.Coronado, C.J.Gomez-Garcia, T.Gelbrich, M.B.Hursthouse|2001|Inorg.Chim.Acta|319|159|doi:10.1016/S0020-1693(01)00449-2
CCDC 801665: Experimental Crystal Structure Determination
2011
Related Article: M.Tuikka, P.Hirva, K.Rissanen, J.Korppi-Tommola, M.Haukka|2011|Chem.Commun.|47|4499|doi:10.1039/c1cc10491h
The Sensor Kinase DctS Forms a Tripartite Sensor Unit with DctB and DctA for Sensing C4-Dicarboxylates in Bacillus subtilis
2013
The DctSR two-component system of Bacillus subtilis controls the expression of the aerobic C4-dicarboxylate transporter DctA. Deletion of DctA leads to an increased dctA expression. The inactivation of DctB, an extracellular binding protein, is known to inhibit the expression of dctA. Here, interaction between the sensor kinase DctS and the transporter DctA as well as the binding protein DctB was demonstrated in vivo using streptavidin (Strep) or His protein interaction experiments (mSPINE or mHPINE), and the data suggest that DctA and DctB act as cosensors for DctS. The interaction between DctS and DctB was also confirmed by the bacterial two-hybrid system (BACTH). In contrast, no indicati…
Polar Localization of a Tripartite Complex of the Two-Component System DcuS/DcuR and the Transporter DctA in Escherichia coli Depends on the Sensor K…
2014
The C4-dicarboxylate responsive sensor kinase DcuS of the DcuS/DcuR two-component system of E. coli is membrane-bound and reveals a polar localization. DcuS uses the C4-dicarboxylate transporter DctA as a co-regulator forming DctA/DcuS sensor units. Here it is shown by fluorescence microscopy with fusion proteins that DcuS has a dynamic and preferential polar localization, even at very low expression levels. Single assemblies of DcuS had high mobility in fast time lapse acquisitions, and fast recovery in FRAP experiments, excluding polar accumulation due to aggregation. DctA and DcuR fused to derivatives of the YFP protein are dispersed in the membrane or in the cytosol, respectively, when …
Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia
2020
Statin therapy has been the cornerstone for the reduction of cholesterol and circulating low-density lipoprotein (LDL) in patients with cardiovascular diseases. However, statin monotherapy has disadvantages attributable to myopathies and to the insufficient cholesterol reduction observed in some patients. There is a need for new well-tolerated therapies for lowering LDL. This review will focus on bempedoic acid in combination with traditional statin therapy or other lipid-lowering agents and its emerging role in LDL-C lowering. Bempedoic acid is also a viable alternative for reducing LDL cholesterol in the treatment of some patients suffering from heterozygous familial hypercholesterolemia.
C2-Symmetric Ferrocene-Bis(ureido)peptides : Synthesis, Conformation and Solid-State Structure
2009
The extension of peptide derivatives of ferrocene-1,1'-dicarboxylic acid by formal insertion of NH units between ferrocene and peptide strands results in ferrocene-bis(ureido)-peptides. Experimentally, alanine and dialanine methyl esters were attached to the 1- and 1'-position of 1,1'-diiso-cyanoferrocene to give the corresponding bis(ureido)peptide derivatives 3 and 4. The conformation of 3 has been determined in the solid state by X-ray crystallography. In solution the preferred conformation of 3 and 4 has been elucidated by NMR, IR and CD spectroscopy in concert with DFT calculations. The secondary structure of ferrocene―bis(ureido)peptides 3 and 4 is determined by double bifurcated intr…