Search results for "dication"
showing 10 items of 733 documents
Selective Inhibition of STAT3 with Respect to STAT1: Insights from Molecular Dynamics and Ensemble Docking Simulations
2016
STAT3 protein, which is known to be involved in cancer development, is a promising target for anticancer therapy. Successful inhibitors of STAT3 should not affect an activity of closely related protein STAT1, which makes their development challenging. The mechanisms of selectivity of several existing STAT3 inhibitors are not clear. In this work, we studied molecular mechanisms of selectivity of 13 experimentally tested STAT3 inhibitors by means of extensive molecular dynamics and ensemble docking simulations. It is shown that all studied inhibitors bind to the large part of the protein surface in an unspecific statistical manner. The binding to the dimerization interface of the SH2 domain, …
Domestication of a Robotic Medication-Dispensing Service Among Older People in Finnish Lapland
2020
This paper presents a case study on a robotic medication-dispensing service used in the everyday lives of older people in Finnish Lapland through the concept of domestication. The study took an ethnographic approach. A total of 11 service users, practical nurses, and other health-care professionals participated; the service users averaged age 81 years (M= 81.4, SD = 5.4). The data comprised semistructured interviews complemented by observations and photographs at service users’ homes. We concluded that the domestication of the service was successful, although the service users sometimes felt that it limited their lives. The service users stated that learning and subsequently using the servi…
Semantic traffic applications based on DatexII
2009
In this work we demonstrate a particular use of ontologies based on the European specifications DATEXII. These specifications are designed and developed as a traffic and travel data exchange mechanism by a European task force to set up and standardise the interface between traffic control and information centres. It is the reference for applications that are developed and implemented in Europe.This language describes concepts and structures of data related to traffic, but the description is just syntactic, not semantic. Therefore the objective to be reached in this part of the research has been to develop a semantic description in order to carry out some applications like syndication and a …
Dicationic Organic Salts: our recent journey in their properties and applications
2014
WHY CORPORATES INVEST IN THE SAME START-UP AN EXPLORATIVE ANALYSIS OF CVC SYNDICATIONS
2016
This study investigates why two or more corporates co-invest in the same start-up syndicating their CVC activities. Based on two strands of literature, the CVC and the alliance, we propose a research framework that explores the possible antecedents of CVC syndications. Particularly, grounded on alliance literature, we look at the CVC syndication by combining two dimensions, relational and technological: the relational dimension describes the competitive or cooperative nature of the relationship between partners of CVC syndications, while the technological one represents the exploitative or explorative technological objectives that corporates could pursue when coinvesting in a start-up. We a…
Rendering in corso...
2022
Introduzione al libro "Gaming" di Alexander R. Galloway Introduction to Alexander R. Galloway's "Gaming" book
« La prédication seconde : Essai de mise au point »
2009
La revue "Travaux de linguistique" consacre son cinquante-septième numéro au problème de la prédication seconde dans le domaine de la linguistique française. À travers une série de contributions relevant de plusieurs domaines d'analyse (syntaxique, pragmatique, sémantique) et portant sur des constructions parfois très disparates, ce numéro vise à présenter un état de la question en matière de prédication seconde, qui, en adoptant une attitude réaliste, se soucie moins de fournir des réponses assurées que de poser les bonnes questions. L'objet de l'enquête est, en effet, compliqué dès le départ: quoiqu'il soit possible, en principe et selon des critères de nature partiellement différente, de…
Cardiovascular Management Self-efficacy: Psychometric Properties of a New Scale and Its Usefulness in a Rehabilitation Context.
2015
Self-efficacy beliefs have been shown to affect various effective health-promoting behaviors in patients. Unfortunately, availability of reliable and valid measures of self-efficacy in cardiovascular diseases (CVDs) is still very limited. Background: Self-efficacy beliefs have been shown to affect various effective health-promoting behaviors in patients. Unfortunately, availability of reliable and valid measures of self-efficacy in cardiovascular diseases (CVDs) is still very limited. Purpose: The aims of this study were to present a new scale measuring self-efficacy beliefs in managing CVD and to examine its psychometric properties. Methods: The study involved 172 patients (mean age = 66.4…
Disease activity states, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etan…
2017
The advent of biologic medications has increased considerably the potential for treatment benefit in juvenile idiopathic arthritis (JIA), with clinical remission being now achievable in a substantial proportion of patients. However, there is a need of data from the real world of clinical practice to evaluate thoroughly the efficacy and safety profile of the biologic agents currently approved.
Efficacy of Low-Dose Paroxetine for the Treatment of Hot Flushes in Surgical and Physiological Postmenopausal Women: Systematic Review and Meta-Analy…
2019
Background and Objectives: Hot flushes and sleep disturbances are the most common vasomotor symptoms (VMS) reported by postmenopausal women. Hormonal treatment is to date referred to as the gold standard approach but not suitable for all the patients. Alternative treatments are needed in case of a contraindication to menopausal hormone therapy (MHT), adverse side effects, and poor compliance. Paroxetine salt is the only nonhormonal medication approved by the US Food and Drug Administration for the management of VMS. Nonetheless, few trials with low consensus are available about this topic. In this review, we aimed to evaluate the efficacy of low-dose paroxetine therapy in the treatment of v…