Search results for "dicer"
showing 10 items of 26 documents
Problems in the identity of "Crioceras" barremense Kilian, 1895 (Ancyloceratida, Late Barremian), and their proposed resolution
2010
17 pages; The study of "Crioceras" barremense KILIAN was undertaken as a part of the revision of the Hemihoplitidae. This species was considered "classic" and has been used as the index of an Upper Barremian subzone; this usage raises a number of problems. The type specimen from Tyrol was a fragment described and illustrated by UHLIG as Crioceras sp. ind. aff. roemeri. This specimen could not be retrieved, and a topotype could not be collected. Our study revealed that there is both a biostratigraphic hiatus and important differences between conceptions of this species: (1) that ascribed UHLIG's type specimen (Upper Barremian, Tyrol), (2) KILIAN's concept of the specimen he found and named "…
Pseudoshasticrioceras bersaci nov. sp. (Ammonoidea, Gassendiceratinae), and new ammonite biohorizon for the Upper Barremian of southeastern France
2009
International audience; Research in the Feraudianus Subzone of the Sartousiana Zone of the Barremian stage led to the discovery of a new species of Pseudoshasticrioceras: P. bersaci nov. sp. Its study provides evidence concerning the developments of the latest Gassendiceratinae BERT et alii, 2006, and the relationship between the genus Pseudoshasticrioceras DELANOY, 1998, and Gassendiceras BERT et alii, 2006. In particular, this new species is derived from Pseudoshasticrioceras magnini (DELANOY, 1992) by a minor revision in the processes of ontogenesis (retardation of ornamentation - neoteny). However, the evolution towards Pseudoshasticrioceras autrani DELANOY, 1998, implies a "failure" in…
Globacrochordiceras gen. nov. (Acrochordiceratidae, late Early Triassic) and its significance for stress-induced evolutionary jumps in ammonoid linea…
2013
<i>Globacrochordiceras transpacificum</i> gen. et sp. nov. is an ammonoid (Ammonoidea, Cephalopoda) with a shell characterized by plicate ribbing (rounded and undulating ribs strengthening on the venter without interruption), increasing involution through ontogeny, overhanging and deep umbilical wall, absence of tuberculation, subtriangular whorl section, globose adult shape with a closed umbilicus followed by an abrupt egressive coiling, and a subammonitic adult suture line. This new taxon occurs in Nevada (USA) and in Guangxi (South China). It has its typical occurrence within the <i>Neopopanoceras haugi</i> Zone of late Spathian age (Early Triassic). The plicate r…
Middle Pleistocene protein sequences from the rhinoceros genus Stephanorhinus and the phylogeny of extant and extinct Middle/Late Pleistocene Rhinoce…
2017
BackgroundAncient protein sequences are increasingly used to elucidate the phylogenetic relationships between extinct and extant mammalian taxa. Here, we apply these recent developments to Middle Pleistocene bone specimens of the rhinoceros genusStephanorhinus. No biomolecular sequence data is currently available for this genus, leaving phylogenetic hypotheses on its evolutionary relationships to extant and extinct rhinoceroses untested. Furthermore, recent phylogenies based on Rhinocerotidae (partial or complete) mitochondrial DNA sequences differ in the placement of the Sumatran rhinoceros (Dicerorhinus sumatrensis). Therefore, studies utilising ancient protein sequences from Middle Pleis…
Dicer prevents genome instability in response to replication stress
2019
Dicer, an endoribonuclease best-known for its role in microRNA biogenesis and RNA interference pathway, has been shown to play a role in the DNA damage response and repair of double-stranded DNA breaks (DSBs) in mammalian cells. However, it remains unknown whether Dicer is also important to preserve genome integrity upon replication stress. To address this question, we focused our study on common fragile sites (CFSs), which are susceptible to breakage after replication stress. We show that inhibition of the Dicer pathway leads to an increase in CFS expression upon induction of replication stress and to an accumulation of 53BP1 nuclear bodies, indicating transmission of replication-associate…
DICER- and MMSET-catalyzed H4K20me2 recruits the nucleotide excision repair factor XPA to DNA damage sites
2017
The endoribonuclease DICER facilitates chromatin decondensation during lesion recognition following UV exposure. Chitale and Richly show that DICER mediates the recruitment of the methyltransferase MMSET, which catalyzes the dimethylation of histone H4 at lysine 20 and facilitates the recruitment of the nucleotide excision repair factor XPA.
De novo transcriptome assembly of a facultative parasitic nematode Pelodera (syn. Rhabditis) strongyloides
2018
Pelodera strongyloides is a generally free-living gonochoristic facultative nematode. The whole genomic sequence of P. strongyloides remains unknown but 4 small subunit ribosomal RNA (ssrRNA) gene sequences are available. This project launched a de novo transcriptome assembly with 100 bp paired-end RNA-seq reads from normal, starved and wet-plate cultured animals. Trinity assembly tool generated 104,634 transcript contigs with N50 contig being 2195 bp and average contig length at 1103 bp. Transcriptome BLASTX matching results of five nematodes (C. elegans, Strongyloides stercoralis, Necator americanus, Trichuris trichiura, and Pristionchus pacificus) were consistent with their evolutionary …
Stable changes in CD4+ T lymphocyte miRNA expression after exposure to HIV-1
2012
Abstract MicroRNAs (miRNAs) inhibit HIV-1 expression by either modulating host innate immunity or by directly interfering with viral mRNAs. We evaluated the expression of 377 miRNAs in CD4+ T cells from HIV-1 élite long-term nonprogressors (éLTNPs), naive patients, and multiply exposed uninfected (MEU) patients, and we observed that the éLTNP patients clustered with naive patients, whereas all MEU subjects grouped together. The discriminatory power of miRNAs showed that 21 miRNAs significantly differentiated éLTNP from MEU patients and 23 miRNAs distinguished naive from MEU patients, whereas only 1 miRNA (miR-155) discriminated éLTNP from naive patients. We proposed that miRNA expression ma…
Role of the Non-Canonical RNAi Pathway in the Antifungal Resistance and Virulence of Mucorales
2021
Mucorales are the causal agents for the lethal disease known as mucormycosis. Mortality rates of mucormycosis can reach up to 90%, due to the mucoralean antifungal drug resistance and the lack of effective therapies. A concerning urgency among the medical and scientific community claims to find targets for the development of new treatments. Here, we reviewed different studies describing the role and machinery of a novel non-canonical RNAi pathway (NCRIP) only conserved in Mucorales. Its non-canonical features are the independence of Dicer and Argonaute proteins. Conversely, NCRIP relies on RNA-dependent RNA Polymerases (RdRP) and an atypical ribonuclease III (RNase III). NCRIP regulates the…
Fasti seicenteschi nella scrittura di Gesualdo Bufalino
2009
Il saggio esamina le peculiarità del barocco dissonante di Gesualdo Bufalino. In Bufalino l’artificio dello stile sottende una tensione ideologica. L’intensità espressiva e l’eccesso verbale cercano di compensare un vuoto e costituiscono, nel sentire dello scrittore, un formidabile mezzo «per contrastare l’ossificazione del mondo». Bufalino rivendica quindi il valore strutturale della propria scelta barocca, dichiarando che la sua scrittura è sorretta da un «barocco borrominiano» in cui «l’ornato è funzione», in mancanza del quale «l’architettura cadrebbe».