Search results for "digestive"
showing 10 items of 2631 documents
Maternal weaning practices and their impact on infant's acceptance of new food
2010
Objective. The introduction of solid foods is a major step in the development of food behaviour. Previous studies showed that higher sensory variety in weaning period can later influence infant's acceptance of new food. The aim of the present study is (i) to describe precisely the different maternal weaning practices, (ii) to relate them with the individual mothers' and infants' characteristics, (iii) to study if these practices could impact infant's acceptance of new foods. Methods. Mothers (n=121) were requested to record each food proposed to their infant detailed from a sensory point of view and to score the level of its acceptance at the 4 first presentations. The beginning of the wean…
Eating a variety of vegetables: the importance of feeding practices at weaning and onwards
2013
Présentation sous forme d'un diaporama (24 diapositives) classé confidentiel; International audience; Eating a varied diet is known to improve the food intake from a nutritional point of view. Weaning (i.e. introduction of complementary foods) is a transitional process between the consumption of a unique food, milk, and family foods. This is the time when the diet gets progressively diversified. Accumulating evidences point towards the role that eating a varied diet as early as the beginning of weaning plays in the development of further food acceptance and healthy eating habits. These studies will be reviewed, as well as other studies underlying more broadly the role played by parental fee…
Characterizing the bacterial fish pathogen Flavobacterium columnare, and some factors affecting its pathogenicity
2010
Flavobacterium columnare is a bacterial pathogen of fresh water fish causing lethal columnaris disease worldwide. At Finnish fish farms, columnaris disease has occurred since the early 1980s, and is a serious problem in salmonid farming in Finland. Currently, the only effective treatment is with antibiotics. Factors related to the pathogenicity of F. columnare, transmission of columnaris disease and the immunity of salmonids to columnaris infections are poorly known. F. columnare strains isolated from Finnish fish farms were characterized geno- and phenotypically, virulence and transmission experiments were conducted, and the efficacy of two immunostimulants against columnaris infections in…
Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
1999
NS5A of the hepatitis C virus (HCV) is a highly phosphorylated protein involved in resistance against interferon and required most likely for replication of the viral genome. Phosphorylation of this protein is mediated by a cellular kinase(s) generating multiple proteins with different electrophoretic mobilities. In the case of the genotype 1b isolate HCV-J, in addition to the basal phosphorylated NS5A (designated pp56), a hyperphosphorylated form (pp58) was found on coexpression of NS4A (T. Kaneko, Y. Tanji, S. Satoh, M. Hijikata, S. Asabe, K. Kimura, and K. Shimotohno, Biochem. Biophys. Res. Commun. 205:320‐326, 1994). Using a comparative analysis of two full-length genomes of genotype 1b…
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase.
2001
The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), represented by nonstructural protein 5B (NS5B), has recently emerged as a promising target for antiviral intervention. Here, we describe the isolation, functional characterization, and molecular cloning of a monoclonal antibody (mAb) inhibiting the HCV RdRp. This mAb, designated 5B-12B7, binds with high affinity to a conformational epitope in the palm subdomain of the HCV RdRp and recognizes native NS5B expressed in the context of the entire HCV polyprotein or subgenomic replicons. Complete inhibition of RdRp activity in vitro was observed at equimolar concentrations of NS5B and mAb 5B-12B7, whereas RdRp activities of classica…
In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.
1996
AbstractProteolytic processing of the nonstructural proteins of the hepatitis C virus (HCV) is mediated by two viral proteinases: the NS2-3 proteinase cleaving at the NS2/3 junction and the NS3 serine-type proteinase responsible for processing at the NS3/4A, NS4A/B, NS4B/5A, and NS5A/B sites. Activity of the NS3 proteinase is modulated by NS4A. In the absence of this cofactor processing at the NS3-dependent sites does not occur or, in the case of the NS5A/B junction, is poor but increased when NS4A is present. Although recent studies demonstrated that proteinase activation requires direct interaction between NS3 and NS4A, the mechanism by which NS4A exerts the activation function is not kno…
Pleasure or health: Do children have to choose?
2017
International audience; Pleasure from eating is known to be a strong predictor of children’s food choices. Yet, children’s food preferences generally do not align with dietary recommendations, children rate energy-dense foods as the most liked and vegetables the least liked. In order to incite children to adopt a healthy diet, parents, caregivers, and national campaigns put forward nutritional arguments. However, there is limited research regarding the impact of the level of nutritional concern on children’s food choices, especially compared to pleasure-oriented goals. This talk is an overview of the research work I have conducted during my PhD, and explores the relationships between childr…
Low-level environmental metal pollution is associated with altered gut microbiota of a wild rodent, the bank vole (Myodes glareolus)
2021
Mining and related industries are a major source of metal pollution. In contrast to the well-studied effects of ex-posure to metals on animal physiology and health, the impacts of environmental metal pollution on the gut mi-crobiota of wild animals are virtually unknown. As the gut microbiota is a key component of host health, it is important to understand whether metal pollution can alter wild animal gut microbiota composition. Using a combination of 16S rRNA amplicon sequencing and quantification of metal levels in kidneys, we assessed whether multi-metal exposure (the sum of normalized levels of fifteen metals) was associated with changes in gut microbiota of wild bank voles (Myodes glar…
Consumption of ultra-processed foods : an assessment of the literature on determinants of ultra-processed food consumption and an investigation of th…
2016
Masteroppgave folkehelsevitenskap - Universitetet i Agder 2016 Background Highly processed foods have been classified as ultra-processed, and consumption of such foodstuffs have expanded rapidly over the last decades. Ultra-processed foods are characterized as being accessible, attractive, palatable and often time-saving. An excess intake of ultra-processed foods has been associated with increased risk of e.g. overweight/obesity and diabetes type II. The aim of this master’s project was to investigate factors influencing consumption of ultra-processed foods. This resulted in one review paper on young adults, and one cross-sectional study where the association between time scarcity and ultra…
Development of Food Preferences and Appetite in the First Years
2016
International audience; Infants are born equipped to ingest nutrients, but have to learn how, what and how much to eat. This must occur early, because the mode of feeding evolves dramatically, from ‘tube’ feeding in utero to eating table foods with the family. Eating habits established during early years contribute to the development of subsequent eating habits. Therefore, it is fundamental to understand the most important early periods for the development of eating habits and the drivers of this development. Here we will focus on the first three years of postnatal life. Several characteristics of the eating experience contribute to drive infant’s eating and to shape preferences and energy …