Search results for "dire"
showing 10 items of 3084 documents
Immediate Effects of Anodal Transcranial Direct Current Stimulation on Postural Stability Using Computerized Dynamic Posturography in People With Chr…
2020
Postural stability is commonly decreased in individuals with chronic post-stroke hemiparesis due to multisystemic deficits. Transcranial direct current stimulation (tDCS) is a non-invasive method to modulate cortical excitability, inducing neuroplastic changes to the targeted cortical areas and has been suggested to potentially improve motor functions in individuals with neurological impairments. The purpose of this double-blinded, sham-controlled study was to examine the acute effects of anodal tDCS over the lesioned motor cortex leg area with concurrent limits of stability training on postural control in individuals with chronic post-stroke hemiparesis. Ten individuals with chronic post-s…
Directly Observed Physical Activity and Fundamental Motor Skills in Four-Year-Old Children in Day Care
2016
Physical activity (PA), its location, social interactions and fundamental motor skills (FMS) were investigated in four-year-old Finnish children in day care. Six skills in the stability, locomotor and manipulative domains were assessed in 53 children (24 boys, 29 girls, normal anthropometry) with the APM-Inventory manual for assessing children’s perceptual and FMS and Total Motor Scores (TMS; 0–6 points) calculated. PA intensity, location, group composition and activity type − sitting, squatting, kneeling − were directly observed with a modified version of the Observational System for Recording Physical Activity in Children – Preschool Version (OSRAC – P) during three consecutive days in 14…
Pulmonary Embolism: Contemporary Medical Management and Future Perspectives
2018
Pulmonary embolism (PE) contributes substantially to the global disease burden. A key determinant of early adverse outcomes is the presence (and severity) of right ventricular dysfunction. Consequently, risk-adapted management strategies continue to evolve, tailoring acute treatment to the patients' clinical presentation, hemodynamic status, imaging and biochemical markers, and comorbidity. For subjects with hemodynamic instability or 'high-risk' PE, immediate systemic reperfusion treatment with intravenous thrombolysis is indicated; emerging approaches such as catheter-directed pharmacomechanical reperfusion might help to minimize the bleeding risk. Currently, direct, non-vitamin K-depende…
P258 Combining tDCS with prismatic adaptation for non invasive neuromodulation of the motor cortex
2017
Introduction Prismatic adaptation (PA) shifts visual field laterally and induces lateralized deviations of spatial attention. Recently, it has been suggested that prismatic goggles are also able to modulate brain excitability ( Magnani, 2014 ), with cognitive after-effects documented even in tasks not necessarily spatial in nature ( Oliveri, 2013 ). Objectives The aim of the present study was to test whether prisms can modulate motor cortical excitability similarly as anodal transcranial direct current stimulation (tDCS) does; to test whether neuromodulatory effects obtained from tDCS and prismatic goggles could interact and induce homeostatic changes in brain excitability. Materials and me…
EFFICACY OF REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION/TRANSCRANIAL DIRECT CURRENT STIMULATION IN COGNITIVE NEUROREHABILITATION
2008
Summary: Cognitive deficits are a common consequence of neurologic disease, in particular, of traumatic brain injury, stroke, and neurodegenerative disorders, and there is evidence that specific cognitive training may be effective in cognitive rehabilitation. Several investigations emphasize the fact that interacting with cortical activity, by means of cortical stimulation, can positively affect the short-term cognitive performance and improve the rehabilitation potential of neurologic patients. In this respect, preliminary evidence suggests that cortical stimulation may play a role in treating aphasia, unilateral neglect, and other cognitive disorders. Several possible mechanisms can accou…
From different neurophysiological methods to conflicting pathophysiological views in migraine: a critical review of literature.
2014
Abnormal increased cortical responsivity to various types of stimuli plays a major role in migraine pathogenesis. Neurophysiological studies, however, have provided ambiguous findings of either hypo or hyper cortical excitability. This is why the term "dysexcitability" has been recently proposed to indicate a more general dysregulation of cortical excitability. The aims of this review are: (1) to provide existing knowledge and research advances in migraine pathophysiology; (2) to propose a unitary interpretation of apparently conflicting neurophysiological findings. Data of studies conducted in migraine through various evoked potentials techniques and non-invasive brain stimulation methods …
A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstituti…
1994
Specific proteolysis by the tetanus toxin light chain of a vesicle-associated membrane protein (VAMP) involved in exocytosis is thought to underlie its intracellular blockade of neurotransmitter release. To substantiate this mechanism, recombinant light chain was expressed as a maltose binding protein-light chain fusion product in Escherichia coli. After purification of affinity chromatography and cleavage with factor Xa, the resultant light chain was isolated and its identity confirmed by Western blotting and N-terminal sequencing. It exhibited activity similar to that of the native light chain in proteolyzing its target in isolated bovine small synaptic vesicles and in hydrolyzing a 62-re…
A Systematic Review of the Effectiveness of Non-Invasive Brain Stimulation Techniques to Reduce Violence Proneness by Interfering in Anger and Irrita…
2020
The field of neurocriminology has proposed several treatments (e.g., pharmacological, brain surgery, androgen-deprivation therapy, neurofeedback) to reduce violence proneness, but unfortunately, their effectiveness has been limited due to their side-effects. Therefore, it is necessary to explore alternative techniques to improve patients’ behavioural regulation with minimal undesirable effects. In this regard, non-invasive brain stimulation techniques, which are based on applying changing magnetic fields or electric currents to interfere with cortical excitability, have revealed their usefulness in alleviating the symptomatology of several mental disorders. However, to our knowledge, there …
Pensamiento crítico y su impacto en el desempeño del proyecto de mejora continua
2022
¿Cómo influye el pensamiento crítico (PC) en el desempeño del proyecto de mejora continua (MC), considerando mediación de las capacidades dinámicas (CDs) que subyacen en dicho proyecto? Guiados por tal interrogante general, la tesis cubre tres aspectos. El primero se centra en la conceptualización y operativización del PC en la organización, bajo un marco de MC, lo cual redunda en el diseño y validación psicométrica de un modelo de medida al respecto. El segundo presenta el mismo alcance que el primero, pero esta vez comprende el constructo CDs del proyecto de MC. El tercero se orienta al contraste empírico de la relación estructural entre PC, CDs y desempeño del proyecto, usando analítica/…
IL PAGAMENTO “NECESSARIAMENTE INTERMEDIATO” DELL’OBBLIGAZIONE PECUNIARIA NELLA LEGISLAZIONE DI DERIVAZIONE EUROPEA: VERSO IL SUPERAMENTO DELL’UNICITÀ…
2015
Il lavoro muove dall’idea di analizzare il sistema delle regole che definiscono, sul piano dell’an, del quando e del quomodo, l’esattezza dell’adempimento che può definirsi (necessariamente) intermediato dell’obbligazione pecuniaria: nella vicenda solutoria della quale, cioè, risulti indefettibile, per volontà della legge o per scelta dei privati, l’interposizione di uno o più soggetti, altri rispetto al debitore e al creditore parti originarie del rapporto obbligatorio, con funzioni ausiliarie. Ciò al fine di saggiare la bontà della ipotesi ricostruttiva in base alla quale l’adempimento dell’obbligazione pecuniaria per mezzo di operazioni di pagamento intermediato non sia governato dalla l…