Search results for "disintegration"
showing 10 items of 57 documents
In Vitro Evaluation of Enteric-Coated HPMC Capsules—Effect of Formulation Factors on Product Performance
2020
A comparative study on different enteric-coated hard capsules was performed. The influence of different formulation factors like choice of enteric polymer, triethyl citrate (TEC) concentration (plasticizer), talc concentrations (anti-tacking agent), and different coating process parameters on the sealing performance of the capsule and the disintegration time were investigated. Furthermore, the influence of different disintegration test methods (with disc vs. without disc and 50 mM U.S. Pharmacopoeia (USP) buffer pH 6.8 vs. biopredictive 15 mM phosphate buffer pH 6.5) was evaluated. All formulations showed sufficient but not equivalent acid resistance when tested. Polymer type was the main f…
Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro ex…
2014
Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate. Three poorly-permeable drugs (atenolol, metformin hydrochloride, and furosemide) exhibiting negative food effect, and one highly-soluble and highly-permeable (metoprolol tartrate), serving as a negative control, were selected for the study. In vitro and in silico tools were used to evaluate the influence of media viscosity on drug bioperformance under fasted and fed conditions. The obtained results demonstrated that increased medium viscosity in the presence…
Unitary theory of the deuteron photodisintegration.
1989
The deuteron photodisintegration in the \ensuremath{\Delta}-resonance region is calculated within a unitary theory of the NN-N\ensuremath{\Delta}-\ensuremath{\pi}NN system coupled to the photon. The photoexcitation amplitude of the \ensuremath{\Delta} is deduced from the ${M}_{1+}$((3/2) pion photoproduction amplitude consistently with its background term and the \ensuremath{\pi}N interaction. The NN-N\ensuremath{\Delta} transition amplitude is obtained from the coupled equations for the NN-N\ensuremath{\Delta}-\ensuremath{\pi}NN system. The one-pion-exchange currents as well as the normal single-nucleon current are included. The polarization parameters are reproduced quantitatively, but th…
U937 variant cells as a model of apoptosis without cell disintegration
2012
AbstractThe variant cell line U937V was originally identified by a higher sensitivity to the cytocidal action of tumor necrosis factor alpha (TNFα) than that of its reference cell line, U937. We noticed that a typical morphological feature of dying U937V cells was the lack of cellular disintegration, which contrasts to the formation of apoptotic bodies seen with dying U937 cells. We found that both TNFα, which induces the extrinsic apoptotic pathway, and etoposide (VP-16), which induces the intrinsic apoptotic pathway, stimulated U937V cell death without cell disintegration. In spite of the distinct morphological differences between the U937 and U937V cells, the basic molecular events of ap…
Exploring Differentiated Disintegration in a Post-Brexit European Union
2019
In the aftermath of the British referendum to leave the European Union and the European Commission's ‘White Paper on the Future of Europe’, it is not only time to take stock of the existing literature on differentiated integration, but also to rethink the perimeters of disintegration. We argue that phenomena such as Brexit embrace forms of differentiation which trigger the need for conceptualizing differentiated disintegration altogether. This article first sketches the path of the scholarly debate in a chronological way to grasp the breadth of existing literature. Second, it discusses differentiated disintegration as a potentially new area for research. Mapping several scenarios for future…
Introducing the Study of Nordic Cooperation
2020
To rediscover Nordic cooperation this article develops a ‘conceptual grammar’ that provides general theoretical ‘images’ of cooperation that are systematically applied. Being supplementary analytical constructs, moreover, these images capture great variety and differentiation in Nordic cooperation. Next, this article provides a review of two sets of literature that are of particular relevance to this thematic issue. The first is a broader literature on European integration. The second is studies of Nordic cooperation. The article closes with an overview of the contributions to this thematic issue.
Between Differentiation and (Dis)Integration – Theoretical Explanations of a Post-Brexit European Union
2021
The authors of this paper provide a critical analysis of the most prominent theoretical vehicles employed in studying differentiated integration in contemporary, post-Brexit Europe. They discuss the descriptive, explanatory, and interpretative potential of the selected theoretical approaches that are applied at the intersection of disintegration and European differentiation discourse. “The holy grail” of the theorising of the dynamic (and accelerating) processes of (dis)integration and differentiation remains undiscovered. Nevertheless, a constant search for theoretical explanation is needed in the in-depth analyses of the current state of the European Union.
Improvement of the thermophilic anaerobic digestion and hygienisation of waste activated sludge by synergistic pretreatment
2019
Hybrid disintegration of waste activated sludge (WAS) before the thermophilic anaerobic stabilization of WAS contributes to the intensification of organic compounds decomposition and increases the effectiveness of the anaerobic stabilization process compared to the fermentation of raw WAS. This article investigates the influence of a chemical-thermal pretreatment procedure with the use of NaOH and freezing by the dry ice on WAS. We found that the hybrid pretreatment of WAS causes higher concentration of released organics in the liquid phase (represented here as a change in soluble chemical oxygen demand - SCOD value) in comparison to these disintegration techniques used separately. The use …
The metric-valued Lebesgue differentiation theorem in measure spaces and its applications
2021
We prove a version of the Lebesgue Differentiation Theorem for mappings that are defined on a measure space and take values into a metric space, with respect to the differentiation basis induced by a von Neumann lifting. As a consequence, we obtain a lifting theorem for the space of sections of a measurable Banach bundle and a disintegration theorem for vector measures whose target is a Banach space with the Radon-Nikod\'{y}m property.
Meson-retardation effects in deuteron photodisintegration below ?-threshold
1989
Mesor-retardation effects in photodisintegration of the deuteron below pion threshold are studied by constructing retarded one-boson-exchange potentials using time-dependent non-covariant perturbation theory. The corresponding retarded meson-exchange currents including retarded vertex currents are derived analogously by gauge-invariant minimal coupling. It is found that retardation effects in the wave functions and in the electromagnetic currents as well have a significant influence on total and differential cross sections.