Search results for "disorders"

showing 10 items of 4560 documents

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

2013

Journal article TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10!-7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10!-8) and BRCA1 mutation carrier (P = 1.1 × 10!-5) breast cancers and altered promot…

TelomeraseMessengerCàncer d'ovariEstrogen receptorAetiology screening and detection [ONCOL 5]0302 clinical medicineBreast cancerRisk FactorsAlternative Splicing; Biomarkers Tumor; Breast Neoplasms; Case-Control Studies; Chromatin; DNA Methylation; Female; Gene Expression Profiling; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Luciferases; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Polymorphism Single Nucleotide; RNA Messenger; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Telomerase; Telomere; GeneticsGenotypeBUCCAL CELLSLuciferasesTelomeraseOligonucleotide Array Sequence AnalysisOvarian Neoplasms0303 health sciencesTumorTelòmerReverse Transcriptase Polymerase Chain ReactionGENETIC-VARIATIONCOMMON VARIANTSSingle Nucleotidetert-clptm1l locus; genome-wide association; genetic-variation; susceptibility loci; buccal cells; fibroblasts; common variants; carcinoma; reverse-transcriptase htert; metaanalysisTelomereAetiology screening and detection Immune Regulation [ONCOL 5]Chromatin3. Good healthTumor Markers Biological030220 oncology & carcinogenesisFemaleFIBROBLASTSGenotypeSUSCEPTIBILITY LOCICARCINOMASingle-nucleotide polymorphismBreast NeoplasmsBiologyReal-Time Polymerase Chain ReactionPolymorphism Single NucleotideArticleCàncer de mama03 medical and health sciencesBreast cancerSDG 3 - Good Health and Well-beingTranslational research [ONCOL 3]Ovarian cancermedicineGeneticsBiomarkers TumorHumansGenetic Predisposition to DiseaseRNA MessengerPolymorphismAlleleGENOME-WIDE ASSOCIATIONMETAANALYSIS030304 developmental biologyMolecular epidemiology Aetiology screening and detection [NCEBP 1]Breast cancer susceptibilityHereditary cancer and cancer-related syndromes [ONCOL 1]Translational research Genomic disorders and inherited multi-system disorders [ONCOL 3]Gene Expression ProfilingDNA Methylationmedicine.diseaseMolecular biologyTERT-CLPTM1L LOCUSTelomereMinor allele frequencyAlternative SplicingGenetic LociCase-Control StudiesRNABiomarkersREVERSE-TRANSCRIPTASE HTERTGenome-Wide Association StudyNature genetics
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Characteristics of frontal and temporal cortex in relation to cognitive dysfunction in Bipolar Disorders

2011

Temporal cortexPsychiatry and Mental healthRelation (database)Settore M-PSI/02 - Psicobiologia E Psicologia FisiologicaWorking memoryPharmacology (medical)CognitionBipolar DisordersPsychologyNeuroscience
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The use of tricyclic antidepressants in the treatment of temporomandibular joint disorders: systematic review of the literature of the last 20 years

2009

Many therapies have been proposed for the management of temporomandibular disorders, including the use of different drugs. However, lack of knowledge about the mechanisms behind the pain associated with this pathology, and the fact that the studies carried out so far use highly disparate patient selection criteria, mean that results on the effectiveness of the different medications are inconclusive. This study makes a systematic review of the literature published on the use of tricyclic antidepressants for the treatment of temporomandibular disorders, using the SORT criteria (Strength of recommendation taxonomy) to consider the level of scientific evidence of the different studies. Followin…

Temporomandibular joint disordersUNESCO::CIENCIAS MÉDICASAntidepressiusAntidepressants:CIENCIAS MÉDICAS [UNESCO]Malalties de l'articulació temporomandibular
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Tratamiento de la anquilosis de la articulación temporomandibular por artroplastia simple

2006

Objetivo: El propósito de este trabajo es mostrar que la artroplastia simple mejora la apertura bucal al tratar la anquilosis temporomandibular. Pacientes y métodos: Fueron tratados ocho pacientes con anquilosis de la articulación temporomandibular por medio de artroplastia simple. Los pacientes fueron evaluados en el postoperatorio por un periodo por lo menos de veinticuatro meses (mínimo 24 y máximo 48 meses). Resultados: De los ocho pacientes (once articulaciones), cinco (62,5%) presentaron afectación unilateral y tres pacientes (37.5%) afectación bilateral de la ATM. La edad media fue de 20 años ± 9 (rango de 3 a 30 años). La máxima apertura bucal en el período preoperatorio fue de 9,25…

Temporomandibular joint disordersUNESCO::CIENCIAS MÉDICASankylosisarthroplastyArticulación temporomandibularanquilosiscirugía:CIENCIAS MÉDICAS [UNESCO]
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Modulation of higher-order olfaction components on executive functions in humans

2015

The prefrontal (PFC) and orbitofrontal cortex (OFC) appear to be associated with both executive functions and olfaction. However, there is little data relating olfactory processing and executive functions in humans. The present study aimed at exploring the role of olfaction on executive functioning, making a distinction between primary and more cognitive aspects of olfaction. Three executive tasks of similar difficulty were used. One was used to assess hot executive functions (Iowa Gambling Task-IGT), and two as a measure of cold executive functioning (Stroop Colour and Word Test-SCWT and Wisconsin Card Sorting Test-WCST). Sixty two healthy participants were included: 31 with normosmia and …

Test de StroopOlfactelcsh:Medicine:Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Thinking::Decision Making [Medical Subject Headings]:Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Sensation::Smell [Medical Subject Headings]AudiologyPrefrontal cortex:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Executive FunctionOlfaction Disorderspiriform cortexHyposmiaOlfactory threshold:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Neuropsychological Tests::Stroop Test [Medical Subject Headings]older-adultsalzheimers-diseaselcsh:SciencePsychiatryMultidisciplinaryCognitive flexibilityCognitionMiddle AgedExecutive functionsSmellCognitive inhibitionNeurology:Diseases::Nervous System Diseases::Neurologic Manifestations::Sensation Disorders::Olfaction Disorders [Medical Subject Headings]FemaleFrontal lobemedicine.symptomPsychologyperformanceResearch ArticleAdultmedicine.medical_specialtyAdolescentOlfactionventromedial prefrontal cortexYoung AdultNeurologiamild cognitive impairmentLòbul frontalPruebas neuropsicológicasmedicineHumansTrastornos del olfatoPsiquiatriaToma de decisionesCognición:Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition [Medical Subject Headings]lcsh:Rdecision-makingOlfactory Perceptionodor identificationdeficits:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Neuropsychological Tests [Medical Subject Headings]:Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Executive Function [Medical Subject Headings]lcsh:QOlfatoStroop effectdiscrimination
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Assessment of test-meal induced autonomic arousal in anorexic, bulimic and control females

1998

This study attempted to measure three different physiological responses to food intake in eating disordered subjects. Skin conductance level (SCL), heart rate and electroencephalogram were recorded before, during and after a test-meal in 42 females (14 anorexic inpatients, 10 bulimic outpatients and 18 control subjects). Significant increase in SCL during the meal was found in anorexics only. Pre-meal SCL was lower in bulimics than in controls and anorexics. No changes were found on heart rate or electroencephalogram in all groups of subjects. This suggests that anorexic inpatients may display a measurable arousal when confronted with a meal, whereas bulimic outpatients and control subjects…

Test mealMealFood intakemedicine.medical_specialtyAutonomic arousalfungidigestive oral and skin physiologymedicine.diseasehumanitiesPhysiological responsesArousalPsychiatry and Mental healthClinical PsychologyEating disordersHeart ratemedicinePsychiatryPsychologyClinical psychologyEuropean Eating Disorders Review
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Towards a Comprehensive Understanding of Body Image: Integrating Positive Body Image, Embodiment and Self-Compassion.

2021

Body image (BI) disturbance is a relevant factor in the etiology and treatment of eating disorders (ED). Although progress has been made in recent decades in understanding BI and its relationship with ED, the efficacy of BI disturbance prevention and intervention programs is still limited. In order to reach deeper understanding of BI disturbance and clarify the interactions between some protective and risk factors related to this construct, we carried out a literature review on some specific BI-related factors that so far have been analyzed independently. We specifically examined positive and negative BI; embodiment and its role in the development of positive and negative BI; and self-compa…

Theoretical-Review ArticlePositive body imagePsychotherapistbody shamebody imagemedia_common.quotation_subjectProtective factorShamemedicine.diseaseself-compassionBF1-990positive embodimentEating disordersIntervention (counseling)medicinePsychologybody image; positive embodiment; body shame; self-compassionConstruct (philosophy)PsychologyGeneral PsychologySelf-compassionmedia_commonPsychologica Belgica
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The alliance-outcome association in group interventions: A multilevel meta-analysis.

2022

Objective: The therapeutic alliance has been studied in group interventions, but its relationship to patient outcome is still controversial. This study systematically reviewed the association of both the member-leader and member-group alliance with patient outcomes, and assessed the effects of several theoretically informed moderators. Method: A three-level meta-analysis was conducted on 57 studies to disentangle within- and between-study variability in the alliance-outcome association. Results: The overall effect size of the unconditional model was r = -.259 (95% CI: -.302, -.214; p < .001), whereas the correlation between alliance and outcome based on the three-level meta-analytic mode…

Therapeutic AllianceMental DisordersProfessional-Patient Relationsgroup therapyPsychotherapyPsychiatry and Mental healthClinical PsychologyTreatment OutcomeAlliance outcome correlation; Group therapy; Therapeutic alliance; Three level meta analysis; Humans; Multilevel Analysis; Professional-Patient Relations; Psychotherapy; Treatment Outcome; Mental Disorders; Therapeutic AllianceAlliance outcome correlationSettore M-PSI/08 - Psicologia ClinicaMultilevel AnalysisHumansthree-level meta-analysisalliance-outcome correlationThree level meta analysisJournal of consulting and clinical psychology
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2016

Abstract Background: The association of attention-deficit/hyperactivity disorder (ADHD) and tic disorder (TD) is frequent and clinically important. Very few and inconclusive attempts have been made to clarify if and how the combination of ADHD+TD runs in families. Aim: To determine the first time in a large-scale ADHD sample whether ADHD+TD increases the risk of ADHD+TD in siblings and, also the first time, if this is independent of their psychopathological vulnerability in general. Methods: The study is based on the International Multicenter ADHD Genetics (IMAGE) study. The present sub-sample of 2815 individuals included ADHD-index patients with co-existing TD (ADHD+TD, n=262) and without …

Tic disordermedicine.medical_specialty05 social sciencesmedicine.diseasebehavioral disciplines and activitiesComorbidityTourette syndrome3. Good health03 medical and health sciences0302 clinical medicineRating scalemental disordersmedicineCriterion validityAttention deficit hyperactivity disorder0501 psychology and cognitive sciencesSiblingPsychologyPsychiatry030217 neurology & neurosurgeryGeneral Psychology050104 developmental & child psychologyClinical psychologyPsychopathologyFrontiers in Psychology
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Early Response to treatment in Eating Disorders: A Systematic Review and a Diagnostic Test Accuracy Meta-Analysis

2016

Objective: Early response to eating disorders treatment is thought to predict a later favourable outcome. A systematic review of the literature and meta-analyses examined the robustness of this concept. Method: The criteria used across studies to define early response were summarised following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnostic Test Accuracy methodology was used to estimate the size of the effect. Results: Findings from 24 studies were synthesized and data from 14 studies were included in the meta-analysis. In Anorexia Nervosa, the odds ratio of early response predicting remission was 4.85(95%CI: 2.94–8.01) and the summary Area Unde…

Time FactorsAnorexia NervosaDiagnostic Tests RoutineReproducibility of Resultscognitive behavioural therapyearly responseFeeding and Eating DisordersClinical PsychologyTreatment OutcomePsychiatry and Mental Healtheating disorderSettore M-PSI/08 - Psicologia Clinicabinge eating disorderHumansfamily therapyBulimia NervosaBinge-Eating DisorderRandomized Controlled Trials as Topic
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