Search results for "dog"
showing 10 items of 1087 documents
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening
2021
During almost all 2020, coronavirus disease 2019 (COVID-19) pandemic has constituted the major risk for the worldwide health and economy, propelling unprecedented efforts to discover drugs for its prevention and cure. At the end of the year, these efforts have culminated with the approval of vaccines by the American Food and Drug Administration (FDA) and the European Medicines Agency (EMA) giving new hope for the future. On the other hand, clinical data underscore the urgent need for effective drugs to treat COVID-19 patients. In this work, we embarked on a virtual screening campaign against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mpro chymotrypsin-like cysteine pro…
Media and corruption scandals in Spain: plaintiffs, magnifiers, accomplices?
2013
Partiendo de la idea según la cual el periodismo es, en regímenes de tradición liberal democrática, un freno a la arbitrariedad de los que gobiernan y de que los medios de comunicación, y en especial la prensa escrita, han acometido la tarea de vigilancia de los casos de corrupción acaecidos en la España democrática, se indaga sobre los mecanismos que dificultan el ejercicio de un periodismo de denuncia de la corrupción política y se proponen orientaciones para acercar la ética periodística a la ética cívica propia de la democracia. Starting from the idea that journalism is, in liberal democratic regimes tradition, a brake on the arbitrariness of those who govern and that the media, particu…
La costruzione di un monumento tra Controriforma e tradizione gotica: la chiesa dei Gesuiti a Sassari
2013
Primo cantiere di costruzione impegnativo avviato dalla Compagnia di Gesù in Sardegna, la fondazione chiesa dei Gesuiti di Sassari è avviata a partire da un disegno classicista. Un cambio alla testa del cantiere è alla base di una radicale trasformazione del progetto nella fase di costruzione del sistema voltato di copertura, con cupola in pietra sulla crociera. Il saggio analizza le diverse tappe del processo costruttivo e le soluzioni, talora del tutto inedite, messe in campo nel passaggio dal progetto originario al suo adattamento a soluzioni e tecniche in uso nella Sardegna del XVI secolo.
Monetary Policy and the Exchange Rate During the Asian Crisis: Identification Through Heteroscedasticity
2003
This paper examines whether a monetary policy tightening (i.e., an increase in the domestic interest rate) was successful in defending the exchange rate from speculative pressures during the Asian financial crisis. We estimate a bivariate VECM for four Asian countries, and improve upon existing studies in two important ways. First, by using a long data span we are able to compare the effects of an interest rate rise on the nominal exchange rate during tranquil and turbulent periods. Second, we take into account the endogeneity of interest rates and identify the system by exploiting the heteroscedasticity properties of the relevant time series, following Rigobon (2002). We find that while ti…
L'identità della scienza giuridica penale nell'ordinamento multilivello
2014
Lo scenario generale dell’attuale ordinamento multilivello pone importanti inter- rogativi alla scienza penale: dai rapporti fra fonti nazionali e sopranazionali alla interazione fra corti diverse, ma che concorrono nella tutela dei diritti fondamen- tali. Nella dinamica nuova dei rapporti tanto fra fonti normative, quanto fra autorità giudicanti non valgono più le tradizionali logiche deduttive di prevalenza gerarchica, ma si affermano nuove forme di influenza reciproca e di interazione. Lo studio, dopo aver chiarito preliminarmente significato e contesti del rapporto fra scienza penale e ordinamento multilivello, intende contribuire alla riflessione in argomento considerando tre settori p…
Pascal y el Deísmo
2008
Este estudio contrapone la visión de Blaise Pascal (1623-1662) acerca del cristianismo al deísmo como religión natural. Después de un breve sumario acerca de los conceptos clave del deísmo, se analizan los textos en los que Pascal cuestiona la absoluta primacía de la razón y propone los límites que separan el orden natural del sobrenatural (revelación positiva). Por último en contraste con el deísmo se abordan, por una parte, los criterios establecidos por Pascal para distinguir lo verdadero y lo falso de una religión, y, por otra, los aspectos que permiten sustentar la verdad de la religión cristiana. (A)
Interpretation of epicardial mapping by means of computer simulations: Applications to calcium, lidocaine and to BRL 34915
1992
The aim of this work was to compare experimental investigations on effects of lidocaine, calcium and, BRL 34915 on reentries to simulated data obtained by use of a model of propagation based on the Huygens' construction method already described in previous works. Calcium and lidocaine effects are investigated on anisotropic conduction conditions. In both cases, reduction in conduction velocities are observed. In lidocaine case, a refractory area is located along the longitudinal axis. In agreement with experimental electrical mapping, the simulations show that the stabilization of reentrant excitation is mainly due to the existence of this refractory area around which the reentrant circuit …
Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme inductio…
2000
The use of primary hepatocytes is now well established for both studies of drug metabolism and enzyme induction. Cryopreservation of primary hepatocytes decreases the need for fresh liver tissue. This is especially important for research with human hepatocytes because availability of human liver tissue is limited. In this review, we summarize our research on optimization and validation of cryopreservation techniques. The critical elements for successful cryopreservation of hepatocytes are (1) the freezing protocol, (2) the concentration of the cryoprotectant [10% dimethyl-sulfoxide (DMSO)], (3) slow addition and removal of DMSO, (4) carbogen equilibration during isolation of hepatocytes and…
Dog blogs as ventriloquism: Authentication of the human voice
2015
This paper looks at personal blogging by dog owners in an international, English language blogsite in which dog owners from around the world report and reflect upon their dogs and their lives with dogs, and do so by using the dog׳s voice. It approaches dog blogs as an example of the strategic use of pervasive but contentious anthropomorphic western discourses about animals and discusses how dog bloggers use anthropomorphism as a discursive means for crafting and collectively ratifying authenticity in a translocal, interest-driven and informal social media context in which traditional territorial and demographic parameters of authenticity are not easily available or relevant. More specifical…
Food products, gastronomy and religious tourism: The resilience of food landscapes
2021
Abstract Religious tourism has always been a sector of significant importance in the field of cultural tourism. Religious tourism is located both in urban areas and in rural areas. In rural areas in the past it did not represent a factor of great impact on the local economy as most of the population lived in rural areas. With the advent of modern society and with the phenomena of agricultural and rural exodus, linked to the increase in income in developed societies, religious tourism becomes a critical success factor for many rural areas as a historical heritage. This aspect is of significant importance if we consider that it can represent a real engine of development especially for rural a…