Search results for "domain"
showing 10 items of 2485 documents
Applying Semiautomatic Generation of Conceptual Models to Decision Support Systems Domain
2009
This paper presents a decision support system specification in the form of business use cases and a stereotyped conceptual model based on the specification. The use cases are based on generic user requirements and address cognitive biases. The specification can be used to set fixed and common terms among the project participants. Semiautomatic generation of the conceptual model is demonstrated with mixed results. While there are some shortcomings in the parsing and the result is dependent on the phrasing conventions used in the use cases, the conceptual model highlights the most essential entities in the domain and provides a base for further development phases. peerReviewed
Un bassin extensif formé pendant la fonte de la calotte glaciaire hirnantienne : le bassin ordovico-silurien de Kandi (Nord Bénin, Sud Niger)
2006
Le long de la bordure occidentale du bassin de Kandi, la sédimentation détritique continentale de base, correspondant à la formation de Wéré, est préservée dans des paléovallées limitées par des failles d'orientation moyenne N20°E, héritées de l'orogenèse panafricaine. Le remplissage sédimentaire de ces paléovallées est représenté par des dépôts conglomératiques et bréchiques de tills glaciaires marquant la base de la série, évoluant verticalement et latéralement vers l'Est à des grès fluviatiles. Ces dépôts continentaux, d'âge supposé ordovicien supérieur, passent verticalement à des grès tidaux et des grès et siltites subtidaux de la Formation de Kandi, d'âge ordovicien terminal à silurie…
No Safe Haven for Truth Pluralists
2021
Truth pluralism offers the latest extension in the tradition of substantive theorizing about truth. While various forms of this thesis are available, most frameworks commit to domain reliance. According to domain reliance, various ways of being true, such as coherence and correspondence, are tied to discourse domains rather than individual sentences. From this follows that the truth of different types of sentences is accounted for by their domain membership. For example, sentences addressing ethical matters are true if they cohere and those addressing extensional states of affairs if they correspond. By tying distinct truth-grounding properties to domains rather than individual sentences, t…
Properties of transmembrane helix TM1 of the DcuS sensor kinase of Escherichia coli, the stator for TM2 piston signaling
2021
Abstract The sensor kinase DcuS of Escherichia coli perceives extracellular fumarate by a periplasmic PASP sensor domain. Transmembrane (TM) helix TM2, present as TM2-TM2′ homo-dimer, transmits fumarate activation in a piston-slide across the membrane. The second TM helix of DcuS, TM1, is known to lack piston movement. Structural and functional properties of TM1 were analyzed. Oxidative Cys-crosslinking (CL) revealed homo-dimerization of TM1 over the complete membrane, but only the central part showed α-helical +3/+4 spacing of the CL maxima. The GALLEX bacterial two-hybrid system indicates TM1/TM1′ interaction, and the presence of a TM1-TM1′ homo-dimer is suggested. The peripheral TM1 regi…
UCOT: Semiautomatic Generation of Conceptual Models from Use Case Descriptions
2008
This paper describes a prototype of a system to auto matically analyze use cases and create a conceptual model based on the analysis. Grammatical parser and Abbott’s heuristic are used to process the use cases. User can modify the conceptual model by refining entities and relations, as well as roles for the entities. The model can be exported to be further utilized with object oriented analysis or domain specific modeling. The system is evaluated based on the analysis of use cases used to describe the system itself. The quality of models depends essentially on the quality and writing conventions of the use cases. If the use cases are written using subject-predicate-object struc ture and usage…
Damping Provision by Different Virtual Synchronous Machine Schemes
2020
The adoption of virtual synchronous machine (VSM) schemes for the control of power converters is gaining more and more attention both in academia and industry. The VSM control strategies fall into the category of grid-forming converter controls, and they are intended for a range of different applications, providing specific services and different kinds of support to the grid. The paper investigates the possibility of damping provision to the system by VSM power converters. Different schemes are considered and compared, showing the opportunity of the investigated solutions through combined modal and time domain analyses. A specific modification of the power synchronization loop is recognized…
Conformational Dynamics of the Dengue Virus Protease Revealed by Fluorescence Correlation and Single-Molecule FRET Studies.
2021
The dengue virus protease (DENV-PR) represents an attractive target for counteracting DENV infections. It is generally assumed that DENV-PR can exist in an open and a closed conformation and that active site directed ligands stabilize the closed state. While crystal structures of both the open and the closed conformation were successfully resolved, information about the prevalence of these conformations in solution remains elusive. Herein, we address the question of whether there is an equilibrium between different conformations in solution which can be influenced by addition of a competitive inhibitor. To this end, DENV-PR was statistically labeled by two dye molecules constituting a FRET …
Human Papillomavirus Types 16, 18, and 31 Share Similar Endocytic Requirements for Entry
2013
ABSTRACT Human papillomavirus type 18 (HPV18), one of the HPVs with malignant potential, enters cells by an unknown endocytic mechanism. The key cellular requirements for HPV18 endocytosis were tested in comparison to those for HPV16 and -31 endocytoses. HPV18 (like HPV16 and -31) entry was independent of clathrin, caveolin, dynamin, and lipid rafts but required actin polymerization and tetraspanin CD151, and the viruses were routed to the same LAMP-1-positive compartment. Hence, the viruses shared similar cellular requirements for endocytic entry.
Impact of VP1-Specific Protein Sequence Motifs on Adeno-Associated Virus Type 2 Intracellular Trafficking and Nuclear Entry
2012
ABSTRACT Adeno-associated virus type 2 (AAV2) has gained much interest as a gene delivery vector. A hallmark of AAV2-mediated gene transfer is an intracellular conformational change of the virus capsid, leading to the exposure of infection-relevant protein domains. These protein domains, which are located on the N-terminal portion of the structural proteins VP1 and VP2, include a catalytic phospholipase A 2 domain and three clusters of basic amino acids. We have identified additional protein sequence motifs located on the VP1/2 N terminus that also proved to be obligatory for virus infectivity. These motifs include signals that are known to be involved in protein interaction, endosomal sort…
Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix
2019
Abstract Coat protein (COP) I and COP II complexes are involved in the transport of proteins between the endoplasmic reticulum and the Golgi apparatus in eukaryotic cells. The formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a type I transmembrane protein. Oligomerization of p24 monomers was suggested to be mediated and/or stabilized via interactions within the transmembrane domain, and the p24 transmembrane helix appears to selectively bind a single sphingomyelin C18:0 molecule. Furthermore, a potential cholesterol-binding sequence has also been predicted in the p24 transmembrane domain. Thus, sphingomyelin and/or cholestero…