Search results for "doxa"
showing 10 items of 68 documents
Scanning electron microscopic and X ray microanalysis study of the mineral deposits in pseudoxanthoma elasticum.
1977
A skin biopsy of a 37 year old man with typical lesions of pseudoxanthoma clasticum (P.E.) associated with angioid streaks (Groenblad-Strandberg Syndrom) was examined with a scanning E. M. (SEM) and a SEM provided with a X ray micro-analyser. The SEM provided with X ray microanalyser enabled us to see the correspondence between the crystalline deposits and a calcium salt. The potassium, sodium and magnesium analysis of the specimen permits us to verify that the P.E. dermis is rich in K and poor in Mg.
Giustificazione epistemica e responsabilità cognitiva nel Teeteto
2011
Sullo sfondo di un'interpretazione della critica al relativismo e allo scetticismo sofistico nel Teeteto che individua come suo esito la delineazione di un'epistemologia del dialeghesthai elenchico incentrata su una concezione fallibilista della verità come homologhia, il saggio cerca di mostrare come in questo dialogo platonico emerga il modello di un rapporto mente-mondo mediato concettualmente e razionalmente, diverso sia dal modello sofistico di conoscenza come passiva aisthesis, sia da quello di una pura conoscenza non contaminata dalla percezione che Platone sembrava voler sostenere con la Teoria dei due mondi. Una tale ipotesi di lettura è centrata sull'identificazione del nucleo più…
A simple high-performance liquid chromatography (HPLC) method for the measurement of pyridoxal-5-phosphate and 4-pyridoxic acid in human plasma.
2014
Abstract Background Low concentration of plasma pyridoxal-5-phosphate (PLP) is associated with hyperhomocysteinemia and inflammation. Most methods for the measurement of plasma PLP require large specimen volume and involve the use of toxic reagents. Methods We have developed a HPLC method for the measurement of PLP and 4-pyridoxic acid (4-PA) in plasma, which requires small specimen volume. The samples are prepared without adding any toxic reagents. Furthermore, we have examined whether intake of vitamin B 6 affects the concentration of plasma PLP and 4-PA. Results The coefficient of variation of the method was 6% and the recovery of the added vitamin in plasma was about 100%. The concentra…
Managing patients taking edoxaban in dentistry
2017
Background Anticoagulation therapy is used in several conditions to prevent or treat thromboembolism. A new group of oral anticoagulants with clear advantages over classic dicoumarin oral anticoagulants (warfarin and acenocoumarol) has been developed in recent years. The Food and Drug Administration has approved edoxaban, dabigatran, rivaroxaban and apixaban. Their advantages include: predictable pharmacokinetics, drug interactions and limited food, rapid onset of action and short half-life. However, they lack a specific reversal agent. Material and methods This paper examines the available evidence regarding rivaroxaban and sets out proposals for clinical guidance of dental practitioners t…
Risk-adapted management of pulmonary embolism
2017
The presence and severity of right ventricular (RV) dysfunction is a key determinant of prognosis in the acute phase of pulmonary embolism (PE). Risk-adapted treatment strategies continue to evolve, tailoring initial management to the clinical presentation and the functional status of the RV. Beyond pharmacological and, if necessary, mechanical circulatory support, systemic thrombolysis remains the mainstay of treatment for hemodynamically unstable patients; in contrast, it is not routinely recommended for intermediate-risk PE. Catheter-directed pharmacomechanical reperfusion treatment represents a promising option for minimizing bleeding risk; for reduced-dose intravenous thrombolysis, the…
A wide family of pyridoxal thiosemicarbazone ferric complexes: Syntheses, structures and magnetic properties
2009
Abstract This study reports the syntheses and the characterization of 12 ferric complexes of pyridoxal thiosemicarbazone. The richness of the coordination chemistry of this ligand is highlighted by the modulation of its charge from neutral H 2 L to anionic L 2− , thus leading to a wide family of ferric compounds with charge varying from +3 to −1. The structures of complexes [Fe(HL) 2 ]ClO 4 · 2H 2 O and [Fe(HL)L] · 4.5H 2 O were solved and discussed with a particular attention brought to the intermolecular interactions occurring between the complexes. The investigation of magnetic properties of these compounds revealed that two of them are in the HS state at any temperature, whereas the ot…
Pyridoxine dependent epilepsies: new therapeutical point of view
2017
Abstract Pyridoxine dependent epilepsies (PDEs) are rare autosomal recessive disorders with onset in neonatal period. Seizures are typically not responsive to conventional antiepileptic drugs, but they cease after parental pyridoxine administration. Atypical forms are characterized partly response to pyridoxine and a late onset of symptoms (up to the age of three years). Prevalence is variable and it has rarely been described. The genes involved in PDEs are the gene encoding for the Alpha-aminoadipic-semialdehyde dehydrogenase (ALDH7A1) and PROSC gene, which encodes a pyridoxal-5-phosphate binding protein. Mutations in the gene encoding for the pyridoxal-5′-phosphate oxidase enzyme (PNPO) a…
Elevated plasma total homocysteine in centenarians
2004
Homocysteine (Hcy) is a sulfur-containing metabolite of methionine and is an emerging independent risk factor for atherosclerosis. Previous studies have shown that age, gender, renal function and folic acid intake are the main factors influencing total plasma Hcy levels in humans. A unique approach to the science of human longevity is the natural model of centenarians. The objective of this study was to verify whether the previously determined risk factors for atherosclerosis and atherosclerosis-related diseases change with age and, finally, to establish the vitamin nutritional status role. We studied 54 centenarians (14 males and 40 females) aged between 100-107 years (mean age 102.6+/-1.8…
PO-0483 Prospective Observational Study Of Doxapram For The Treatment Of Apnea Of Prematurity
2014
Background and aims After the implementation of a local treatment protocol at our NICU, we aimed to systematically evaluate if intubation for apnea of prematurity was avoided by doxapram. We asked, if frequency and severity of apneas were affected and if side effects occurred. Methods We prospectively analysed all premature infants 2 and side effects an hour before, at the start of, and during 48 h after onset of treatment. Results 21 of 66 (31.8%) infants (mean gestational age 25.5 weeks, mean birth weight 705 g) were treated during 2½ years. All of them had been treated with caffeine and CPAP before doxapram was applied. In 13 of 67 (19%) therapy courses, infants were intubated because of…
The role of nutrients in the biodegradation of 2,4,6-trinitrotoluene in liquid and soil.
2011
The widely used explosive 2,4,6-trinitrotoluene (TNT) has residues that are potentially explosive, toxic, and mutagenic. TNT and other explosives can be degraded by microorganisms; however, biostimulation is needed for process efficiency. To investigate the effectiveness of using biostimulation to degrade TNT, we added varying concentrations of a nutrient amendment consisting of inorganic salts, plant extracts, and molasses to soil and liquid media. For the inoculum we used a consortium of bacteria AM 06 that had exhibited the ability to degrade TNT and which had been previously isolated from explosives-contaminated soils. Phylogenetically, the clones clustered into seven different genera: …