Search results for "driver"
showing 10 items of 114 documents
Sedimentary Ancient DNA (sedaDNA) Reveals Fungal Diversity and Environmental Drivers of Community Changes throughout the Holocene in the Present Bore…
2021
Fungi are ecologically important in several ecosystem processes, yet their community composition, ecophysiological roles, and responses to changing environmental factors in historical sediments are rarely studied. Here we explored ancient fungal DNA from lake Lielais Svētiņu sediment throughout the Holocene (10.5 kyr) using the ITS metabarcoding approach. Our data revealed diverse fungal taxa and smooth community changes during most of the Holocene with rapid changes occurring in the last few millennia. More precisely, plankton parasitic fungi became more diverse from the Late Holocene (2–4 kyr) which could be related to a shift towards a cooler climate. The Latest Holocene (~2 kyr) showed …
Fine‐grain beta diversity of Palaearctic grassland vegetation
2021
QUESTIONS: Which environmental factors influence fine-grain beta diversity of vegetation and do they vary among taxonomic groups? LOCATION: Palaearctic biogeographic realm. METHODS: We extracted 4,654 nested-plot series with at least four different grain sizes between 0.0001 m² and 1,024 m² from the GrassPlot database, covering a wide range of different grassland and other open habitat types. We derived extensive environmental and structural information for these series. For each series and four taxonomic groups (vascular plants, bryophytes, lichens, all), we calculated the slope parameter (z-value) of the power law species–area relationship (SAR), as a beta diversity measure. We tested whe…
Climate and socio-economic factors explain differences between observed and expected naturalization patterns of European plants around the world
2021
Pouteau, R., et al.
Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease-Associated Colorectal Cancer.
2021
doi: 10.1053/j.gastro.2021.04.042 Background & Aims Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (IBD-CRC) may represent a distinct pathway of tumorigenesis compared to sporadic CRC (sCRC). Our aim was to comprehensively characterize IBD-associated tumorigenesis integrating multiple high-throughput approaches, and to compare the results with in-house data sets from sCRCs. Methods Whole-genome sequencing, single nucleotide polymorphism arrays, RNA sequencing, genome-wide methylation analysis, and immunohistochemistry were performed using fresh-frozen and formalin-fixed tissue sam…
Immuno-targeted combinations in oncogene-addicted non-small cell lung cancer
2018
The identification of tumor “oncogenic drivers” and the subsequent development of targeted therapy represented a milestone in the treatment of lung cancer over the last years. Tumor genotyping has been incorporated into therapeutic decision making of advanced non-small cell lung cancer (NSCLC) since has become clear that individuals with actionable molecular alterations receiving a matched targeted agent certainly live longer and better. The recent understanding of biological mechanisms underlying cancer immune evasion has allowed the development of a new class of immunomodulatory agents which are able to reactivate host immune-response, offering the potential for long-term disease control …
Standardized on-road tests assessing fitness-to-drive in people with cognitive impairments: A systematic review.
2020
Objective The on-road assessment is the gold standard because of its ecological validity. Yet existing instruments are heterogeneous and little is known about their psychometric properties. This study identified existing on-road assessment instruments and extracted data on psychometric properties and usability in clinical settings. Method A systematic review identified studies evaluating standardized on-road evaluation instruments adapted for people with cognitive impairment. Published articles were searched on PubMed, CINHAL, PsycINFO, Web of Science, and ScienceDirect. Study quality and the level of evidence were assessed using the COSMIN checklist. The collected data were synthetized usi…
Constructions of Agency in Accounts of Drunk Driving at the Outset of Semi-Mandatory Counseling
2015
Convicted drunk drivers, in accounts of their offenses, rarely display qualities of agency that would contribute to a favorable outcome in counseling. Instead, the discursive and rhetorical aim of the accounts is often to evade responsibility and ownership of the offending behavior. Such disclaim of personal agency can be achieved in various ways in the narration of drunk driving (DD) incidences. This study examined how five aspects of agentic presentation (reflexivity, historicity, intentionality, causal attribution, and relationality) were present in or missing from such accounts. It was found that a tentative model of (non)agentic display based on those five aspects could differentiate b…
Analysis of Kinematic Parameters and Driver Behavior at Turbo Roundabouts
2018
This study focuses on both vehicle kinematic parameters (speed and acceleration) and behavior parameters (critical interval and follow-up time) of drivers at turbo-roundabouts. Empirical evaluations of such parameters can be helpful in calibrating traffic microsimulation models or assigning behavior parameters to closed-form capacity models in turbo-roundabouts (gap-acceptance capacity models) and are also related to evaluation of vehicles pollutant emissions. The research was based on traffic process observed in the first turbo-roundabout implemented in the city of Maribor in Slovenia. In 2016 a great number of traffic samples were taken with high-frame-rate video recordings [>50 frames pe…
Availability, demand, perceived constraints and disuse of ADAS technologies in Spain: findings from a national study
2019
Advanced Driver Assistance Systems (ADAS), created for enhancing the driving experience and actively preventing road crashes, have been progressively incorporated in vehicle designing essentially during the last decade. However, the literature has shown how some of these assisting technologies are not used by drivers in tandem with their potential. The aims of this study were, first, to examine the availability and demand of ADAS technologies among Spanish drivers and, secondly, to explore the perceived constraints and discouraging reasons for avoiding the use of ADAS available in their vehicles. For this national cross-sectional study, data from 1,207 Spanish drivers were analyzed. The res…
Comparison of quantitative Holocene temperature reconstructions using multiple proxies from a northern boreal lake
2017
Four biotic proxies (plant macrofossils, pollen, chironomids and diatoms) are employed to quantitatively reconstruct variations in mean July air temperatures ( Tjul) at Lake Loitsana (northern Finland) during the Holocene. The aim is to evaluate the robustness and biases in these temperature reconstructions and to compare the timing of highest Tjul in the individual reconstructions. The reconstructed Tjul values are evaluated in relation to local-scale/site-specific processes associated with the Holocene lake development at Loitsana as these factors have been shown to significantly influence the fossil assemblages found in the Lake Loitsana sediments. While pollen-based temperatures follow…