Search results for "drosophila"

Correction: Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a Drosophila model of myotoni…

2018

ABSTRACT Myotonic dystrophy (DM) is a dominantly inherited neuromuscular disorder caused by expression of mutant myotonin-protein kinase (DMPK) transcripts containing expanded CUG repeats. Pathogenic DMPK RNA sequesters the muscleblind-like (MBNL) proteins, causing alterations in metabolism of various RNAs. Cardiac dysfunction represents the second most common cause of death in DM type 1 (DM1) patients. However, the contribution of MBNL sequestration in DM1 cardiac dysfunction is unclear. We overexpressed Muscleblind (Mbl), the Drosophila MBNL orthologue, in cardiomyocytes of DM1 model flies and observed a rescue of heart dysfunctions, which are characteristic of these model flies and resem…

Biocontrol of drosophila suzukii by two fatty acids

2020

International audience; Olfaction is a crucial sense for insects to detect food, seek partners or escape dangers. Volatile molecules are mainly perceived through insects' antenna. Odors bind to specific olfactory receptors located in sensilla. Olfactory sensory neurons then synapse on corresponding specific glomeruli of the antennal lobe, the primary olfaction center. This olfactory information is processed in higher centers to trigger a behavioral response. Understanding how odors can influence insect behavior is fundamental in order to protect cultures from pests. In this work, 2 volatile fatty acids are shown to modify significantly Drosophila suzukii courtship and copulation at increasi…

Molecular mechanisms of cytoplasmic polyadenylation in drosophila

2012

Drosophila early embryogenesis is an ideal system to study control of gene expression at the post transcriptional level, since at this stage there is little or no transcription. This first section gives a brief overview on early development in Drosophila. Since in this thesis, toll, a maternal mRNA implicated in the establishment of the dorso-ventral axis during early stages of embryonic development, is used as a model to uncover the molecular mechanism of cytoplasmic polyadenylation at this developmental stage.

A Drosophila model to study the human multysistemic disease Williams Beuren sindrome

2005

Evolution of Complex Acoustic Signals in Drosophila Species

2009

species produce complex acous-tic cues, so-called courtship songs, while pursuing a female.In most of the over 100 species studied so far (see thelist of these species in Hoikkala, 2005), such cues areproduced by wing vibration. Other mechanisms of songproduction include abdomen purring (Hoy, Hoikkala, &Kaneshiro, 1988) and rapid vibrations of the whole body(Ritchie & Gleason, 1995). The carrier frequency of songsproduced through any of these actions ranges from 150 to500Hz. A hitherto unknown mechanism enables males ofsome Hawaiian species to generate songs of up to 15,000Hz(Hoikkala, Hoy, & Kaneshiro, 1989).The structure of the courtship songs of closely relatedspecies often reflects phylo…

Larval Arrest in Development of Tribolium castaneum (Coleoptera: Tenebrionidae)

1986

Arrested larval development (in the last larval instar) of part of the total larval population has been detected in moderately crowded situations (40 larvae in 2 g food) in Tribolium castaneum (Herbst) cultures This phenomenon is the same found previously in highly crowded cultures of Drosophila melanogaster (Meigen) and other related species. The arrest may be viewed as a mechanism of physiological adaptation of organisms to competitive situations.

Involvement of circadian oscillation(s) in the photoperiodic time measurement and the induction of reproductive diapause in a northern Drosophila spe…

2013

An ability to predict forthcoming changes in environmental conditions and get prepared for them in advance is crucial for the survival and reproduction of organisms living in a seasonally changing environment. We have studied the possible involvement of circadian oscillator(s) in the photoperiodic timer controlling seasonal responses by tracing Drosophila montana females' diapause induction in constant darkness and in a classical Nanda-Hamner experiment. Nearly all females developed ovaries in continuous darkness, which shows the direct development to be their default developmental pathway in the absence of photoperiods. In Nanda-Hamner experiment the females' diapause incidence was close t…

Expression of neurotrophins, GDNF, and their receptors in rat thyroid tissue

1999

Levels of mRNA for neurotrophins (brain-derived neurotrophic factor, BDNF; neurotrophin 3, NT-3; neurotrophin 4, NT-4) and their receptors (trkA, trkB, trkC) and for glial cell line-derived neurotrophic factor (GDNF) and its receptors (ret, GDNFR-alpha) were measured in rat thyroid tissue by ribonuclease protection assays. In thyroid tissue the NT-3 mRNA level was threefold lower and the NT-4 mRNA level sixfold higher than those detected in adult rat hippocampus, while BDNF mRNA was undetectable. Very low levels of mRNA for truncated trkB and trkC receptors and no catalytic trkA, trkB or trkC were found. In conclusion NT-3 and NT-4, but not the corresponding functional receptors, are expres…

Tyramine Actions on

2017

The biogenic amines octopamine (OA) and tyramine (TA) modulate insect motor behavior in an antagonistic manner. OA generally enhances locomotor behaviors such as Drosophila larval crawling and flight, whereas TA decreases locomotor activity. However, the mechanisms and cellular targets of TA modulation of locomotor activity are incompletely understood. This study combines immunocytochemistry, genetics and flight behavioral assays in the Drosophila model system to test the role of a candidate enzyme for TA catabolism, named Nazgul (Naz), in flight motor behavioral control. We hypothesize that the dehydrogenase/reductase Naz represents a critical step in TA catabolism. Immunocytochemistry rev…

Impact of

2018

Drosophila melanogaster has been for over a century the model of choice of several neurobiologists to decipher the formation and development of the nervous system as well as to mirror the pathophysiological conditions of many human neurodegenerative diseases. The rare disease Friedreich’s ataxia (FRDA) is not an exception. Since the isolation of the responsible gene more than two decades ago, the analysis of the fly orthologue has proven to be an excellent avenue to understand the development and progression of the disease, to unravel pivotal mechanisms underpinning the pathology and to identify genes and molecules that might well be either disease biomarkers or promising targets for therap…