Search results for "dry eye"
showing 10 items of 75 documents
Dažāda veida mākslīgo asaru ietekme uz sausās acs radītajām pazīmēm un simptomiem
2021
Maģistra darbs ir uzrakstīts angļu valodā uz 5 5 lappaspusēm. Tas satur 13 attēlus, 19 tabulas un 30 atsauces uz literatūras avotiem. Šī pētījuma mērķis ir novērtēt dažādu mākslīgo asaru ietekmi uz sausu acu simptomiem un pazīmēm. Sauso acu slimība (DED) ir hroniska, daudzfaktoru acu virsmas slimība, kas noved pie diskomforta, redzes traucējumiem un asaru plēvītes nestabilitātes, ar iespējamu acu virsmas bojājumu. Vecums un dzimums tiek mi nēts par svarīgākajiem faktoriem, kas izraisa sauso acu slimību, turpretī citi riski bieži netiek ņemti vērā. Lai nozīmētu DED ārstēšanu, jāveic dažādi diagnostikas testi. Mūsdienās ir pieejamas atšķirīgas ārstēšanas metodes, bet mākslīgās asaras ir visbi…
Tears as a source of biomarkers for ocular and systemic diseases
2013
The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers which are correlated with a certain disease. Tear proteins have been investigated extensively in the past and distinct relations between the levels of certain tear proteins to different disorders have been demonstrated. In this review we attempt to summarize proteomic technologies for biomarker identification in tears and some disease related biomarkers in tear fluids that were discovered through different proteomic techniques in different conditions like dry eye, Sjogren's syndrome, contact lens wearers, glaucoma, diabetic retinopathy or cancer. Proteomic analysis of tear fluid has proven to be a pr…
Improvement of dry eye symptoms with polyunsaturated fatty acids
2006
International audience; Purpose: Polyunsaturated fatty acids (PUFA) are involved in inflammatory pathways via prostaglandins. Conjunctival inflammation is a hallmark of all dry eye syndromes. We investigated the role of dietary n–6 and n–3 fatty acids in patients suffering from ocular dryness with peculiar attention to inflammatory markers. Methods: 70 patients presenting with mild to moderate dry eye syndromes were randomly assigned to Nutrilarm® or placebo pills, thrice a day for 6 months. Schirmer test, BUT, fluorescein and lissamin green stainings were performed at inclusion and after 1, 3 and 6 months. Impression cytology to evaluate MHCII antigens was harvested at D0, Month 3 and 6. T…
Presbyopia and the aging eye: Existing refractive approaches and their potential impact on dry eye signs and symptoms.
2020
Every part of the human body is subject to aging, including the eye. Increased prevalence of dry eye disease with age is widely acknowledged: aging threatens ocular surface homeostasis, altering the normal functioning of the lacrimal functional unit and potentially leading to signs and symptoms of dry eye. Parallelly, two additional degenerative processes take place within the crystalline lens, leading to presbyopia and cataractogenesis. With continuously increasing life expectancies both conditions are expected to impact society further. Correction strategies for presbyopia and cataracts either directly or indirectly challenge ocular surface additionally. On one hand, contact lens presbyop…
The tear film and the optical quality of the eye
2010
The stability of the tear film plays an important role in the optical quality of the eye. Various methods have been developed to quantify the contribution of the tear film to optical quality, including the double-pass optical method, Hartmann-Shack wavefront sensing, videokeratoscopy, retroillumination analysis, and interferometry. In addition to assessing the effect of tear film irregularities, these methods can aid in the diagnosis of dry-eye related conditions and the monitoring of therapy. This review describes the methodologies used to assess the relationship between the tear film and optical quality of the eye and summarizes the most important findings obtained with these methods with…
Time Course of Inflammation and Apoptosis in a Scopolamine–Induced Dry Eye Rat Model
2006
International audience; Purpose: : Dry eye syndrome is due to tear secretion deficiency or excessive tear evaporation leading to tear film instability. The aim of this study was to evaluate the time course of inflammation and apoptosis in a scopolamine–induced dry eye rat model. Methods: : Osmotic pumps continuously delivering scopolamine (12.5mg/d) were implanted subcutaneously in female Lewis rats for 1, 2, 3, 7, 10, 17 and 28 days. During the treatment, the corneal status was assessed by fluorescein impregnation and tears were collected for prostaglandin E2 (PGE2) immunoassay. At the end of the treatment period, the animals were sacrificed and the ocular tissues and the lacrimal glands w…
Tear <sup>1</sup>H Nuclear Magnetic Resonance-Based Metabolomics Application to the Molecular Diagnosis of Aqueous Tear Deficiency and Me…
2020
<b><i>Purpose:</i></b> Meibomian gland dysfunction (MGD) is a major cause of signs and symptoms related to dry eyes (DE) and eyelid inflammation. We investigated the composition of human tears by metabolomic approaches in patients with aqueous tear deficiency and MGD. <b><i>Methods:</i></b> Participants in this prospective, case-control pilot study were split into patients with aqueous tear deficiency and MGD (DE-MGD [<i>n</i> = 15]) and healthy controls (CG; <i>n</i> = 20). Personal interviews, ocular surface disease index (OSDI), and ophthalmic examinations were performed. Reflex tears collected by capillarity were pr…
Non-invassive assessment of the tear film and the ocular surface: Effect of contact lenses
2022
El diagnóstico y tratamiento del síndrome del ojo seco es un reto debido al carácter multifactorial de la enfermedad y la falta de un test clínico “gold standard”. Además, la falta de correlación entre los signos y síntomas de la enfermedad del ojo seco, la falta de correlación entre métricas, su baja repetibilidad, su carácter invasivo y su relativa objetividad dificulta el estudio de la película lagrimal y el diagnóstico de la enfermedad del ojo seco. En el Capítulo 1 del presente trabajo se describen las características principales de la película lagrimal y la enfermedad del ojo seco, y se realiza una revisión bibliográfica sobre técnicas no invasivas de análisis de la película lagrimal …
The role of dry eye disease in cataract and refractive surgery
2019
El síndrome de ojo seco (DED) puede jugar un papel importante en las cirugías oftálmicas con fines refractivos tanto corneales (tratamiento corneal laser) como cristalinianas (cirugía de catarata) pero también en aquellas cuyo fin es controlar la presión intraocular en pacientes que sufren de glaucoma. El objetivo principal de esta tesis se refiere a la aplicación de una serie de pruebas diagnósticas, de mínimamente a no-invasivas, sugeridas por el Tear Film & Ocular Society Dry Eye WorkShop II (TFOS DEWS II) que pueden ayudar a mejorar los resultandos refractivos y visuales en la cirugía oftálmica actual. La cirugía de cristalino, particularmente la cirugía moderna de catarata y la refract…
Valoración de los parámetros geométricos del menisco lagrimal mediante tomografía de coherencia óptica, y su aplicación en el diagnóstico diferencial…
2022
La unidad funcional lagrimal es un sistema integral formado por las glándulas lagrimales y de Meibomio, la superficie ocular (córnea y conjuntiva) y los párpados, así como los nervios sensoriales y motores que los conectan. El mecanismo homeostático de la unidad funcional lagrimal regula la secreción y distribución de la lágrima en respuesta a las señales de la superficie ocular, siendo uno de sus principales objetivos el mantenimiento de una adecuada película lagrimal precorneal. La película lagrimal está formada por dos capas, una capa lipídica externa y un gel muco-acuoso interno en contacto con el glicocálix del epitelio corneal. De vital importancia para su formación es el menisco lagr…