Search results for "duplication"
showing 6 items of 216 documents
Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphoma
2001
Abstract Patients with mantle cell lymphoma (MCL) may present with either nodal or leukemic disease. The molecular determinants underlying this different biologic behavior are not known. This study compared the pattern of genetic abnormalities in patients with nodal and leukemic phases of MCL using comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH) for specific gene loci. Although both leukemic and nodal MCL showed similar genomic patterns of losses (involving 6q, 11q22-q23, 13q14, and 17p13) and gains (affecting 3q and 8q), genomic loss of chromosome 8p occurred more frequently in patients with leukemic disease (79% versus 11%,P < .001). Subsequent…
¿Existe violencia en las parejas del mismo sexo?
2010
El presente artículo intenta dar respuestas a preguntas relacionadas con la existencia o inexistencia de violencia en parejas del mismo sexo. Al igual que intenta explicar cómo es esta violencia, a qué es debida, y si es similar a la violencia que ejercen los hombres contra las mujeres. Concluyendo el mismo, con diferentes propuestas de trabajo en relación a la violencia que se da dentro de las parejas del mismo sexo a nivel individual, familiar, grupal y comunitario. This article sets out to provide replies to questions connected with the existence or nonexistence of violence in same-sex couples. It likewise attempts to explain what this violence is like, what its causes are, and whether t…
Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.
2001
ABSTRACT Studies of the Hepatitis C virus (HCV) replication cycle have been made possible with the development of subgenomic selectable RNAs that replicate autonomously in cultured cells. In these replicons the region encoding the HCV structural proteins was replaced by the neomycin phosphotransferase gene, allowing the selection of transfected cells that support high-level replication of these RNAs. Subsequent analyses revealed that, within selected cells, HCV RNAs had acquired adaptive mutations that increased the efficiency of colony formation by an unknown mechanism. Using a panel of replicons that differed in their degrees of cell culture adaptation, in this study we show that adaptive…
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture.
2003
Studies on the replication of hepatitis C virus (HCV) have been facilitated by the development of selectable subgenomic replicons replicating in the human hepatoma cell line Huh-7 at a surprisingly high level. Analysis of the replicon population in selected cells revealed the occurrence of cell culture-adaptive mutations that enhance RNA replication substantially. To gain a better understanding of HCV cell culture adaptation, we characterized conserved mutations identified by sequence analysis of 26 independent replicon cell clones for their effect on RNA replication. Mutations enhancing replication were found in nearly every nonstructural (NS) protein, and they could be subdivided into at …
Skrzydlate słowa w demotywatorach
2020
The observation of winged words on the Internet shows that the most memorable ones are those that come from the school reading canon and that they become an element of verbal-visual games in demotivators. At the same time, the Internet has become a catalyst, a place where very quickly the emergence of new units takes place. It is infl uenced by its unlimited range and technical capabilities that allow copying, duplication and modifi cation of new units. Adding a graphical element to them in the demotivators strengthens their impact on the recipient, allows them to evoke various emotions and, as a result, easier to remember and willing to share them with subsequent Internet users.
Conservation of the positions of metazoan introns from sponges to humans
2002
Abstract Sponges (phylum Porifera) are the phylogenetic oldest Metazoa still extant. They can be considered as reference animals (Urmetazoa) for the understanding of the evolutionary processes resulting in the creation of Metazoa in general and also for the metazoan gene organization in particular. In the marine sponge Suberites domuncula , genes encoding p38 and JNK kinases contain nine and twelve introns, respectively. Eight introns in both genes share the same positions and the identical phases. One p38 intron slipped for six bases and the JNK gene has three more introns. However, the sequences of the introns are not conserved and the introns in JNK gene are generally much longer. Intron…