Search results for "dynamic"
showing 10 items of 12329 documents
The Catalytic Mechanism of Steroidogenic Cytochromes P450 from All-Atom Simulations: Entwinement with Membrane Environment, Redox Partners, and Post-…
2019
Cytochromes P450 (CYP450s) promote the biosynthesis of steroid hormones with major impact on the onset of diseases such as breast and prostate cancers. By merging distinct functions into the same catalytic scaffold, steroidogenic CYP450s enhance complex chemical transformations with extreme efficiency and selectivity. Mammalian CYP450s and their redox partners are membrane-anchored proteins, dynamically associating to form functional machineries. Mounting evidence signifies that environmental factors are strictly intertwined with CYP450s catalysis. Atomic-level simulations have the potential to provide insights into the catalytic mechanism of steroidogenic CYP450s and on its regulation by e…
Dissipative lattice model with exact traveling discrete kink-soliton solutions: Discrete breather generation and reaction diffusion regime
1999
International audience; We introduce a nonlinear Klein-Gordon lattice model with specific double-well on-site potential, additional constant external force and dissipation terms, which admits exact discrete kink or traveling wave fronts solutions. In the nondissipative or conservative regime, our numerical simulations show that narrow kinks can propagate freely, and reveal that static or moving discrete breathers, with a finite but long lifetime, can emerge from kink-antikink collisions. In the general dissipative regime, the lifetime of these breathers depends on the importance of the dissipative effects. In the overdamped or diffusive regime, the general equation of motion reduces to a di…
Subharmonic and homoclinic bifurcations in the driven and damped sine-Gordon system
1999
Abstract Chaotic responses induced by an applied biharmonic driven signal on the sine-Gordon (sG) system influenced by a constant dc-driven and the damping fields are investigated using a collective coordinate approach for the motion of the breather in the system. For this biharmonic signal, one term has a large amplitude at low frequency. Thus, the classical Melnikov method does not apply to such a system; however, we use the modified version of the Melnikov method to homoclinic bifurcations of the perturbed sG system. Additionally resonant breathers are studied using the modified subharmonic Melnikov theory. This dynamic behavior is illustrated by some numerical computations.
Determination of particle number and brightness using a laser scanning confocal microscope operating in the analog mode
2008
We describe a method to obtain the brightness and number of molecules at each pixel of an image stack obtained with a laser scanning microscope. The method is based on intensity fluctuations due to the diffusion of molecules in a pixel. For a detector operating in the analog mode, the variance must be proportional to the intensity. Once this constant has been calibrated, we use the ratio between the variance and the intensity to derive the particle brightness. Then, from the ratio of the intensity to the brightness we obtain the average number of particles in the pixel. We show that the method works with molecules in solution and that the results are comparable to those obtained with fluctu…
Microwave and optical data fusion for global mapping of soil moisture at high resolution
2018
After more than 8 years in orbit the Soil Moisture and Ocean Salinity (SMOS) satellite is still in good health and several algorithms for improving its spatial resolution have been proposed and validated in a variety of catchments. However, none of them has yet been applied at the global scale. In this article we present: i) a review of the latest SMOS-BEC downscaling algorithm, which allows for its global application using an adaptive moving window and ii) a thorough validation of the resulting maps over two in-situ networks: REMEDHUS in Spain and OzNet in Australia. The proposed algorithm combines SMOS brightness temperatures (at ~40 km spatial resolution), and MODIS-derived Land Surface …
Emerging dynamics in surfactant-based liquid mixtures: octanoic acid/bis(2-ethylhexyl) amine systems.
2012
This work focuses on the dynamic phenomena emerging in self-assembled transient intermolecular networks formed when two different surfactants are mixed. In particular, the relaxation processes in liquid mixtures composed by bis(2-ethylhexyl)amine (BEEA) and octanoic acid (OA) in the whole composition range has been investigated by dielectric spectroscopy and Brillouin spectroscopy. A thorough analysis of all the experimental data consistently suggests that, mainly driven by acid-base interactions arising when the two surfactants are mixed, supra-molecular aggregates formation causes the slowing down of molecular dynamics. This, in turn, reflects to longer-range relaxations. These changes ha…
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
2014
International audience; : Transverse and longitudinal relaxation times (T1ρ and T1 ) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand comprises at least two coupled spins. Herein we broaden the scope of ligand screening by LLS to arbitrary ligands by covalent attachment of a functional group, which comprises a pair of coupled protons that are isolated from neighboring magnetic nuclei. The resulting functionalized ligands have longitudinal relaxation times T1 ((1) H) that are sufficiently long to allow the powerf…
The Bronze Age in Lorraine: a proposed model of the settlement
2022
Thirty years of assiduous preventive archaeology practice in Lorraine have built up a stock of data that can be used for numerous archaeological problems with a spatial focus.For the Bronze Age, as for the other chronological periods, the archaeological occupations discovered during diagnostics and excavations are strongly correlated with current developments (motorways, TGV, housing estates, quarries, etc.). These occupations must be discussed in order to estimate their spatial representativeness. Similarly, the landscape characterisation, in which the occupations highlighted are situated, is an important step in defining the types of settlement.As most of the data comes from the national …
ArchaeDyn. Dynamique spatiale du peuplement et ressources naturelles : vers une analyse intégrée dans le long terme, de la Préhistoire au Moyen Âge,.…
2008
Rapport de fin de contrat d'ACI
Pressure-induced chemical decomposition of copper orthovanadate (α-Cu3V2O8)
2021
The high pressure stability of α-Cu3V2O8 has been investigated via complementary high pressure synchrotron X-ray diffraction experiments and theoretical density functional theory calculations. The results of both experiment and theory are in close agreement. The main result of this work is that α-Cu3V2O8 undergoes a pressure-induced chemical decomposition into CuO and V2O5 at a modest pressure of ∼1.35 GPa according to the experimental observations, and at ∼2.45 GPa according to the calculations. The decomposition is investigated with enthalpy calculations and one of the main driving factors is the stability of the octhedral oxygen-coordination of the metal atoms in the decompositon product…