Search results for "dynamic"
showing 10 items of 12329 documents
Exploring kainate receptor pharmacology using molecular dynamics simulations.
2010
Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure as an approach to evaluate ligand–iGluR pharmacology. The ligands are docked into the closed ligand-binding domain and during the molecular dynamics (MD) simulation the bi-lobed interface either opens (partial agonist/antagonist) or stays closed (agonist) according to the properties of the ligand. The procedure is tested with closely related set of analogs of the marine toxin dysiherbaine bound to GluK1 kainate receptor. The modeling is set against the abundant binding data …
Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism
2012
N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist of two GluN1 and GluN2 monomers. The extracellular ligand-binding domain (LBD) of a monomer is comprised of discontinuous segments that form the functional domains D1 and D2. While the binding of a full agonist glycine to LBD of GluN1 is linked to cleft closure and subsequent ion-channel opening, partial agonists are known to activate the receptor only sub-maximally. Although the crystal structures of the LBD of related GluA2 receptor explain the mechanism for the partial a…
Earth system data cubes unravel global multivariate dynamics
2020
Understanding Earth system dynamics in light of ongoing human intervention and dependency remains a major scientific challenge. The unprecedented availability of data streams describing different facets of the Earth now offers fundamentally new avenues to address this quest. However, several practical hurdles, especially the lack of data interoperability, limit the joint potential of these data streams. Today, many initiatives within and beyond the Earth system sciences are exploring new approaches to overcome these hurdles and meet the growing interdisciplinary need for data-intensive research; using data cubes is one promising avenue. Here, we introduce the concept of Earth system data cu…
The polarization of European agriculture: spatial and dynamic features within a non parametric framework
2009
We present a study of the polarization of European agriculture at NUTS2 regional level. The analysis of selected indicators focuses on spatial and dynamic features of distributions. We make use of the non parametric technique of stochastic kernel which allows to explore the features of a whole distribution and to point out the clustering of statistical units.
Profilo dell'attività scientifica di Fabiola Ardizzone
2018
Si ripercorre l'attività scientifica della compianta Collega Fabiola Ardizzone, dai suoi esordi come allieva della Cattedra di Archeologia Cristiana dell'Università di Palermo, all'attività di insegnamento e di ricerca sul campo in qualità di Professore Associato. Il contributo dato da Fabiola Ardizzone agli studi sulla Tarda Antichità e sul Medioevo siciliani hanno riguardato molteplici direttrici di ricerca: dall'identificazione di nuove classi ceramiche alle modalità di organizzazione delle aree funerarie, dai problemi di topografia urbana all'archeologia dei cimiteri e ai problemi della produzione e circolazione delle produzioni ceramiche. The paper traces the scientific activity of Fab…
Detecting crop water requirement indicators in irrigated agroecosystems from soil water content profiles: An application for a citrus orchard.
2022
Abstract Most perennial crops sensitive to water scarcity, such as citrus, can benefit from efficient water management, which allows for reduced water consumption while increasing crop production on a long-term basis. However, when implementing water-saving strategies, it is necessary to monitor soil and/or plant water status in order to determine crop water demand. A plethora of devices providing indirect measurements of volumetric soil water content, such as the “drill and drop” multi-sensors probes (Sentek, Inc., Stepney, Australia), have been developed over the last decade. The objective of the paper was to analyse time-series of soil water content profiles and meteorological data colle…
AN EXTENDED KALMAN FILTER BASED TECHNIQUE FOR ON-LINE IDENTIFICATION OF UAS PARAMETERS.
2015
The present article deals with the identification,at the same time, of aircraft stability and control parameters taking into account dynamic damping derivatives. Such derivatives,due to the rate of change of the angle of attack, are usually neglected. So the damping characteristics of aircraft dynamics are attributed only on pitch rate derivatives. To cope with the dynamic effects of these derivatives, authors developed devoted procedures to estimate them. In the present paper, a complete model of aerodynamic coefficients has been tuned-up to identify simultaneously the whole set of derivatives. Besides, in spite of the employed reduced order model and/or decoupled dynamics, a six degrees o…
An Extended Kalman Filter-Based Technique for On-Line Identification of Unmanned Aerial System Parameters
2015
ABSTRACT: The present article deals with the identification, at the same time, of aircraft stability and control parameters taking into account dynamic damping derivatives. Such derivatives, due to the rate of change of the angle of attack, are usually neglected. So the damping characteristics of aircraft dynamics are attributed only on pitch rate derivatives. To cope with the dynamic effects of these derivatives, authors developed devoted procedures to estimate them. In the present paper, a complete model of aerodynamic coefficients has been tuned-up to identify simultaneously the whole set of derivatives. Besides, in spite of the employed reduced order model and/or decoupled dynamics, a s…
Adaptive BEM for Low Noise Propeller Design
2009
A potential-based Boundary Element Method is presented for the aerodynamic and acoustic design of propel- lers at on- and off-design point conditions. Using an adaptive method, a family of airfoil sections is selected to produce the required performance (thrust, torque and efficiency versus advance ratio) at different cruise flight levels. Climb condi- tions are also considered in order to check the off-design point performance. Once the available airfoil data have been stored in a database, the code processes the families of airfoils to generate a complete geometry for a propeller of the specified performance with an optimized noise emission. The computational scheme adjusts the blade geom…
Leading edge erosion of wind turbine blades: Effects of blade surface curvature on rain droplet impingement kinematics
2020
Abstract The issue of leading edge erosion (LEE) of wind turbine blades (WTBs) is a complex problem that reduces the aerodynamic efficiency of blades, and affects the overall cost of energy. Several research efforts are being made at the moment to counter erosion of WTBs such as-testing of advanced coating materials together with development of high-fidelity computational models. However, the majority of these studies assume the coated surfaces as flat, while the surface curvature and the shape of the aerofoil at the blade’s leading-edge exposed to such rain fields is neglected. The present study questions the assumption of a flat surface, in the context of LEE of WTBs, and provides guideli…