Search results for "dynamics."

Retention pharmacokinetic and pharmacodynamic parameter relationships of antihistamine drugs using biopartitioning micellar chromatography

2001

Abstract Antihistamines are drugs which act by competitive inhibition of the H1 or H2 histamine receptors. Little has been known about their clinical pharmacokinetics and biological responses until the last few years. In this paper, we propose quantitative retention–activity relationship, QRAR, models based on the retention data of antihistamines in a biopartitioning micellar chromatography (BMC) system using a Brij35 mobile phase for describing pharmacokinetic parameters such as half-life and volume of distribution, or the pharmacodynamic parameters, therapeutic plasma levels, lethal doses and drug-receptor dissociation constant. The predictive ability of these models is statistically vali…

Pharmacokinetic/Pharmacodynamic Model of Neutropenia in Real-Life Palbociclib-Treated Patients

2021

Palbociclib is an oral CDK4/6 inhibitor indicated in HR+/HER2- advanced or metastatic breast cancer in combination with hormonotherapy. Its main toxicity is neutropenia. The aim of our study was to describe the kinetics of circulating neutrophils from real-life palbociclib-treated patients. A population pharmacokinetic (popPK) model was first constructed to describe palbociclib pharmacokinetic (PK). Individual PK parameters obtained were then used in the pharmacokinetic/pharmacodynamic (PK/PD) model to depict the relation between palbociclib concentrations and absolute neutrophil counts (ANC). The models were built with a population of 143 patients. Palbociclib samples were routinely collec…

Numerical and experimental study of hydrostatic displacement machine

2012

This paper presents a simulation tool to determine the structural deflections and corresponding leakage flow in a hydrostatic displacement motor. The simulation tool is applied to a new motor principle that is categorized as an extreme low-speed high-torque motor with dimensions that calls for attention to the volumetric efficiency. To counteract structural deflections the motor is equipped with compensation pressure volumes that may be used to limit the leakage flow across the end faces of the circular rotor. This leakage flow is investigated by solving Reynolds equation for the pressure distribution across both end faces. The fluid pressure is combined with structural calculations in a fl…

Aging Effects in a Lennard-Jones Glass

1997

Using molecular dynamics simulations we study the out of equilibrium dynamic correlations in a model glass-forming liquid. The system is quenched from a high temperature to a temperature below its glass transition temperature and the decay of the two-time intermediate scattering function C(t_w,t+t_w) is monitored for several values of the waiting time t_w after the quench. We find that C(t_w,t+t_w) shows a strong dependence on the waiting time, i.e. aging, depends on the temperature before the quench and, similar to the case of spin glasses, can be scaled onto a master curve.

The dynamical equation of the effective gluon mass

2011

In this article we derive the integral equation that controls the momentum dependence of the effective gluon mass in the Landau gauge. This is accomplished by means of a well-defined separation of the corresponding "one-loop dressed" Schwinger-Dyson equation into two distinct contributions, one associated with the mass and one with the standard kinetic part of the gluon. The entire construction relies on the existence of a longitudinally coupled vertex of nonperturbative origin, which enforces gauge invariance in the presence of a dynamical mass. The specific structure of the resulting mass equation, supplemented by the additional requirement of a positive-definite gluon mass, imposes a rat…

Enhancing Waste Governance through Dynamic Performance Management. An analysis of the Sicilian Waste System.

Synergistic and Antagonistic Effects of Combined Subzero Temperature and High Pressure on Inactivation of Escherichia coli

2006

ABSTRACT The combined effects of subzero temperature and high pressure on the inactivation of Escherichia coli K12TG1 were investigated. Cells of this bacterial strain were exposed to high pressure (50 to 450 MPa, 10-min holding time) at two temperatures (−20°C without freezing and 25°C) and three water activity levels (a w ) (0.850, 0.992, and ca. 1.000) achieved with the addition of glycerol. There was a synergistic interaction between subzero temperature and high pressure in their effects on microbial inactivation. Indeed, to achieve the same inactivation rate, the pressures required at −20°C (in the liquid state) were more than 100 MPa less than those required at 25°C, at pressures in t…

Correction: “On-the-fly” coupled cluster path-integral molecular dynamics: impact of nuclear quantum effects on the protonated water dimer

2015

We present an accelerated ab initio path-integral molecular dynamics technique, where the interatomic forces are calculated “on-the-fly” by accurate coupled cluster electronic structure calculations. In this way not only dynamic electron correlation, but also the harmonic and anharmonic zero-point energy, as well as tunneling effects are explicitly taken into account. This method thus allows for very precise finite temperature quantum molecular dynamics simulations. The predictive power of this novel approach is illustrated on the example of the protonated water dimer, where the impact of nuclear quantum effects on its structure and the 1H magnetic shielding tensor are discussed in detail.

Performance analysis of photovoltaic powered dc motor — Propeller system

2015

The application of autonomous directly photovoltaic (PV) powered electro-mechanical has received increasing attention for different applications (e.g. PV water pumping, PV powered cooling of arid climate greenhouses, solar vehicles etc). The PV array output is a nonlinear and time-dependent power supply that varies with solar intensity and cell temperature, so the performance characteristics of the directly PV-powered DC motor — propeller system are very different than when powered by a constant DC voltage. The focus of this work is to do performance analysis of directly PV-powered DC motor — propeller system. Through performance evaluation, it has been observed that power transfer matching…

Numerical and experimental investigation of a cross-flow water turbine

2016

ABSTRACTA numerical and experimental study was carried out for validation of a previously proposed design criterion for a cross-flow turbine and a new semi-empirical formula linking inlet velocity to inlet pressure. An experimental test stand was designed to conduct a series of experiments and to measure the efficiency of the turbine designed based on the proposed criterion. The experimental efficiency was compared to that from numerical simulations performed using a RANS model with a shear stress transport (SST) turbulence closure. The proposed semi-empirical velocity formula was also validated against the numerical solutions for cross-flow turbines with different geometries and boundary c…