Search results for "dynamics"
showing 10 items of 9782 documents
A multicenter, double-blind, randomized, placebo-controlled trial of the β3-adrenoceptor agonist solabegron for overactive bladder
2012
Abstract Background β-Adrenoceptor agonists are effective in animal models of bladder dysfunction, and the human bladder primarily expresses the β3 receptor subtype. Objective To evaluate the efficacy and tolerability of the highly selective and potent β3-adrenoceptor agonist solabegron in a clinical proof-of-concept study in incontinent women with overactive bladder (OAB). Design, setting, and participants This was a randomized, double-blind trial in adult women with OAB (one or more 24-h incontinence episodes and eight or more average 24-h micturitions). Interventions Solabegron 50mg ( n =88), solabegron 125mg ( n =85), or placebo ( n =85)—all twice daily—were administered. Outcome measur…
Equivalence of the 3-month and 28-day formulations of triptorelin with regard to achievement and maintenance of medical castration in women with endo…
2003
OBJECTIVE: The present study aims at demonstrating the equivalence of the 28-day and 3-month formulations of triptorelin SR (sustained release) in terms of percentage of patients achieving castration levels of estradiol (<==50 pg/mL) 84 days after treatment initiation. DESIGN: A phase II, prospective, randomized, multicenter, open study was conducted in two parallel groups of women with endometriosis. SETTING: Academic hospitals. PATIENT(S): Seventy-two women with endometriosis. were treated with a single intramuscular injection of 3-month triptorelin SR, and 74 patients were treated with one intramuscular injection of 28-day triptorelin SR every 28 days for 3 months. INTERVENTION(S): As pa…
Cizolirtine Citrate, an Effective Treatment for Symptomatic Patients with Urinary Incontinence Secondary to Overactive Bladder: A Pilot Dose-Finding …
2009
Abstract Background A dose-finding study was performed as the first step in the clinical development of the new drug, cizolirtine citrate. Objective To assess the efficacy and safety of cizolirtine citrate in overactive bladder with urinary incontinence. Design, setting, and participants Seventy-nine outpatients with clinical overactive bladder and/or urodynamic diagnosis of detrusor overactivity were randomized in a multicentre, 12-wk, double-blind, pilot trial. Interventions Patients received cizolirtine citrate 400mg bid (C400), cizolirtine citrate 200mg bid (C200), or placebo. Measurements Patients recorded efficacy variables in 7- and 14-d bladder diaries: urinary incontinence episodes…
Impact of Thoracic Endografting on the Hemodynamics of the Native Aorta: Pre- and Postoperative Assessments of Wall Shear Stress and Vorticity Using …
2021
Purpose To quantify the hemodynamic consequences of thoracic endovascular aortic repair (TEVAR) by comparing the preoperative and postoperative wall shear stress (WSS) and vorticity profiles on computational fluid dynamics (CFD) simulations. Materials and Methods The pre- and postoperative computed tomography (CT) scans from 20 consecutive patients (median age 69 years, range 20–87) treated for different thoracic aortic pathologies (11 aneurysms, 5 false aneurysms, 3 penetrating ulcers, and 1 traumatic aortic rupture) were segmented to construct patient-specific CFD models using a meshless code. The simulations were run over the cardiac cycle, and the WSS and vorticity values measured at th…
Microalbuminuria fractional clearance and early renal permselectivity changes in essential hypertension.
1992
In order to verify if, in essential hypertension (EH), the microalbuminuria (AER) increase could be due to hemodynamic modifications or to glomerular structural changes, in 15 essential hypertensives (EHs) with 24-hour AER16 micrograms/min and in 15 EHs with 24-hour AERor = 16 micrograms/min, the day- and nighttime behavior of creatinine clearance (Ccr), as well as AER clearance (AER-C) and fractional clearance (AER-FC), and behavior of blood pressure (BP) was evaluated. Patients with 24-hour AER16 micrograms/min showed significantly higher values of 24-hour and daytime Ccr than the other group of EHs, while during the night period, there were no significant differences between the two grou…
Numerical approach to problems of gravitational instability of geostructures with advected material boundaries
1998
SUMMARY We present a numerical approach for solving 2-D mantle flow problems where the chemical composition changes abruptly across intermediate boundaries. The method combines a Galerkin-spline technique with a method of integration over regions bounded by advected interfaces to represent discontinuous variations of material parameters. It allows direct approximation of a natural free surface position, instead of a posteriori calculation of topography from the normal stress at the upper free-slip boundary. We formulate a model where a viscous incompressible fluid filling a square box is divided into layers (not necessarily horizontal) by advected boundaries, across which the density and vi…
Aerodynamics of Ski Jumping
2016
Ski jumping is an exciting and primarily competitive sport involving both ballistic and aerodynamic factors. The ballistic factors are release velocity and release position of a ski jumper from the take-off table, whereas aerodynamic factors include the gliding properties of the jumper/ski system (velocity, suit design, surface area, posture of the jumper/ski system, resisting and lifting forces). Both ballistic and aerodynamic factors place special demands on the jumper so that he/she can, for example, optimally maximize the vertical lift and minimize the drag forces. Ski jumping has attracted spectators 200 years and it has undergone several notable steps in the development of performance…
Unconventional Aeronautical Investigatory Methods: The Case of Alitalia Flight AZ 112
2021
Viene svelato scientificamente la causa del disastro aereo di Montagna Longa del 5 maggio 1972 Based on unconventional air investigation techniques, this book highlights the mysterious crash of Alitalia flight AZ 112 on 5 May 1972, which killed 115 people, and was blamed solely on pilot negligence. Its findings show the cause of the disaster was not actually related to any pilot negligence, but, rather, it was the result of a criminal act. It argues that this attack was a symptom of the geopolitical tensions in Italy and Europe in that decade. Based on unconventional air investigation techniques, this book highlights the mysterious crash of Alitalia flight AZ 112 on 5 May 1972
Towards comprehensive non-target screening using heart-cut two-dimensional liquid chromatography for the analysis of organic atmospheric tracers in i…
2021
Abstract Non-target screening of secondary organic aerosol compounds in ice cores is used to reconstruct atmospheric conditions and sources and is a valuable tool to elucidate the chemical profiles of samples with the aim to obtain as much information as possible from one mass spectrometric measurement. The coupling of mass spectrometry to chromatography limits the results of a non-target screening to signals of compounds within a certain polarity range based on the utilized stationary phases of the columns. Comprehensive two-dimensional liquid chromatography (LCxLC) introduces a second column of different functionality to enable the analysis of a broader range of analytes. Conventional LCx…
TAKEOFF AND LANDING ROBUST CONTROL SYSTEM FOR A TANDEM CANARD UAV
2005
In spite of modern wide improvements in UAV’s technologies, a few number of such a vehicles is fully autonomous from takeoff to landing . So, either autonomous operation or operation with minimal human intervention is, actually, the primary design goal for the UAV’s researchers. The core of the problem is the design of the landing and takeoff control system. The objective of this paper is to design a control system in which the same state variables are controlled during both the descending/ascending path and the flare, tacking into account the actual ground effect. Robust control techniques are employed with the aim to cope with atmospheric turbulence, measurement noise, parameter variation…