Search results for "eGFR."

Patrones de amplificación de EGFR en el glioblastoma, e identificación de biomarcadores implicados en sus principales vías de señalización

2022

En España, más de 4000 personas serán diagnosticadas anualmente con un tumor maligno cerebral que en su mayoría recaerán en el grupo que se denomina Gliomas Malignos. La mayoría son glioblastomas (grado IV) (GB), siendo estos el tipo más agresivo. Se espera que la supervivencia media para los pacientes tratados con protocolo estándar sea de alrededor de 15 meses. La esperanza de vida tan reducida se debe a que son tumores muy proliferativos y heterogéneos. Esto subraya la necesidad de buscar alternativas para mejorar su manejo. Los estudios de esta tesis se centran en caracterizar biomarcadores y alteraciones genéticas en los diferentes estatus de presentación del EGFR que permitan abordar …

Primary glioblastomas with and without EGFR amplification: Relationship to genetic alterations and clinicopathological features

2009

Glioblastomas express a notable heterogeneity in both the histological and cell patterns with glial astrocytic differentiation. Primary glioblastoma, which is the most frequent presentation (90-95%), occurs mainly in older patients and arises de novo, without any clinical or histological evidence of a less malignant precursor lesion. EGFR amplification has been identified as a genetic hallmark of primary glioblastomas and occurs in 40-60% of cases. However, there exist primary glioblastomas without EGFR amplification/overexpression. The purpose of this study was to stabilize the association between cases with and without EGFR gene amplification with clinical and genetic parameters in 45 cas…

Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors

2014

Fragments based on the VEGFR2i Semaxanib (SU5416, (vascular endothelial growth factor receptor-2\ud inhibitor) and the HDACi (histone deacetylase inhibitor) SAHA (suberanilohydroxamic acid) have been\ud merged to form a range of low molecular weight dual action hybrids. Vindication of this approach is\ud provided by SAR, docking studies, in vitro cancer cell line and biochemical enzyme inhibition data as well\ud as in vivo Xenopus data for the lead molecule (Z)-N1-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)-\ud N8-hydroxyoctanediamide 6.

Influence of dose adjustment on afatinib safety and efficacy in patients (pts) with advanced EGFR mutation-positive (EGFRm plus ) non-small cell lung…

2015

8073 Background: Afatinib 40 mg/day (oral) is approved for the treatment of pts with advanced EGFRm+ NSCLC. Dose adjustment is recommended according to pre-defined tolerability criteria. We perform...

189TiP Phase IV trial of afatinib followed by osimertinib versus osimertinib alone as first-line treatment in patients (pts) with advanced EGFR mutat…

2021

Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA

2018

Abstract: BACKGROUND: The impact of treating OSA on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different CPAP modalities. The aim of this study was to evaluate the respective influence of fixed and autoadjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database cohort. METHODS: In patients of the European Sleep Apnea Database, eGFR prior to and after follow-up was calculated by using the Chronic Kidney Disease-Epidemiology Collaboration equation. Three study groups were investigated: untreated patients (n = 14…

Age-dependent regulation of antioxidant genes by p38α MAPK in the liver

2018

p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work was to assess whether p38α controls the antioxidant defense in the liver, and if so, to elucidate the mechanism(s) involved and the age-related changes. For this purpose, we used liver-specific p38α-deficient mice at two different ages: young-mice (4 months-old) and old-mice (24 months-old). The liver of young p38α knock-out mice exhibited a decrease in GSH levels and an increase in GSSG/GSH ratio and malondialdehyde levels. However, old mice deficient in p38α had higher hepatic GSH levels and lower GSSG/GSH ratio than young p38α knock-…

SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells

2012

Abstract SAHA, an inhibitor of histone deacetylase activity, has been shown to sensitize tumor cells to apoptosis induced by TRAIL, a member of TNF-family. In this paper we investigated the effect of SAHA/TRAIL combination in two breast cancer cell lines, the ERα−positive MCF-7 and the ERα−negative MDA-MB231. Treatment of MDA-MB231 and MCF-7 cells with SAHA in combination with TRAIL caused detachment of cells followed by anoikis, a form of apoptosis which occurs after cell detachment, while treatment with SAHA or TRAIL alone did not produce these effects. The effects were more evident in MDA-MB231 cells, which were chosen for ascertaining the mechanism of SAHA/TRAIL action. Our results show…

Hitler A Bayreuth. Storia di un'amicizia (1923-1940)

2013

Il saggio si sofferma sulle vite parallele di Winifred Majorie Williams (moglie di Sigfried Wagner e dopo la sua morte "Signora di Bayreuth") e Adolf Hitler, grande ammiratore dell'opera wagneriana e "amico" di famiglia della famiglia Wagner a partire dalla fine degli anni Venti. Il testo ripercorre le tappe del rapporto personale fra Winifred Wagner e Adolf Hitler, rievocando al tempo stesso alcuni episodi della biografia hitleriana legati al Festival di Bayreuth.

Kracauer, Siegfried: Werke. Hrsg. von Inka Mülder-Bach und Ingrid Belke. – Frankfurt am Main: Suhrkamp. [Bd.] 4. Geschichte – Vor den letzten Dingen.…

2010

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