Search results for "edge"
showing 10 items of 3866 documents
In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells
2006
Many stem cell types have been shown to differentiate into endothelial cells (ECs); however, their specification to arterial or venous endothelium remains unexplored. We tested whether a specific arterial or venous EC fate could be induced in human multipotent adult progenitor cells (hMAPCs) and AC133(+) cells (hAC133(+)). In vitro, in the presence of VEGF(165), hAC133(+) cells only adopted a venous and microvascular EC phenotype, while hMAPCs differentiated into both arterial and venous ECs, possibly because hMAPCs expressed significantly more sonic hedgehog (Shh) and its receptors as well as Notch 1 and 3 receptors and some of their ligands. Accordingly, blocking either of those pathways …
Comparative study assessing effects of sonic hedgehog and VEGF in a human co-culture model for bone vascularisation strategies.
2011
The morphogen sonic hedgehog (Shh) seems to mediate adult repair processes in bone regeneration and vascularisation. In this study we investigated the effects of Shh on co-cultures consisting of human primary osteoblasts and outgrowth endothelial cells in terms of angiogenic activation and vessel maturation in comparison to the treatment with the commonly used proangiogenic factor, VEGF. Both, stimulation with VEGF or Shh, leads to an increase in the formation of microvessel-like structures compared to untreated controls. In contrast to VEGF, proangiogenic effects by Shh could already be observed after 24 h of treatment. Nevertheless, after 14 days the angiogenic activity of OEC was compara…
Sonic hedgehog promotes angiogenesis and osteogenesis in a coculture system consisting of primary osteoblasts and outgrowth endothelial cells.
2009
A number of previous studies documented the angiogenic potential of outgrowth endothelial cells in vitro and in vivo and provided evidence that therapeutic success could depend on coculture or coimplantation strategies. Thus, deeper insight into the molecular mechanisms underlying this pro-angiogenic effect of cocultures might provide new translational options for tissue engineering and regenerative medicine. One promising signaling pathway in bone repair involved in neoangiogenesis and bone formation is the sonic hedgehog (Shh) pathway. In this article, we focus on the effect of Shh on the formation of microvessel-like structures and osteoblastic differentiation in cocultures of primary os…
BEGIN: Big Data Enabled Energy-Efficient Vehicular Edge Computing
2018
Vehicular edge computing is essential to support future emerging multimedia-rich and delay-sensitive applications in vehicular networks. However, the massive deployment of edge computing infrastructures induces new problems including energy consumption and carbon pollution. This motivates us to develop BEGIN (Big data enabled EnerGy-efficient vehIcular edge computiNg), a programmable, scalable, and flexible framework for integrating big data analytics with vehicular edge computing. In this article, we first present a comprehensive literature review. Then the overall design principle of BEGIN is described with an emphasis on computing domain and data domain convergence. In the next section, …
Multi-Layer Offloading at the Edge for Vehicular Networks
2020
This paper proposes a multi-layer platform for job offloading in vehicular networks. Offloading is performed from vehicles in the Vehicular Domain towards Multi-Access Edge Computing (MEC) Servers deployed at the edge of the network, and between MEC Servers. Offloading decisions at both domains are challenging for the overall system performance. Optimization at the MEC Layer domain is obtained by model-based Reinforcement Learning, while a strategy to decide the best offloading rate from the Vehicular Domain is defined to achieve the desired trade-off between costs and performance. Numerical analysis shows the achieved performance.
Energy-Efficient Edge Computing Service Provisioning for Vehicular Networks: A Consensus ADMM Approach
2019
In vehicular networks, in-vehicle user equipment (UE) with limited battery capacity can achieve opportunistic energy saving by offloading energy-hungry workloads to vehicular edge computing nodes via vehicle-to-infrastructure links. However, how to determine the optimal portion of workload to be offloaded based on the dynamic states of energy consumption and latency in local computing, data transmission, workload execution and handover, is still an open issue. In this paper, we study the energy-efficient workload offloading problem and propose a low-complexity distributed solution based on consensus alternating direction method of multipliers. By incorporating a set of local variables for e…
Decremental 2- and 3-connectivity on planar graphs
1996
We study the problem of maintaining the 2-edge-, 2-vertex-, and 3-edge-connected components of a dynamic planar graph subject to edge deletions. The 2-edge-connected components can be maintained in a total ofO(n logn) time under any sequence of at mostO(n) deletions. This givesO(logn) amortized time per deletion. The 2-vertex- and 3-edge-connected components can be maintained in a total ofO(n log2n) time. This givesO(log2n) amortized time per deletion. The space required by all our data structures isO(n). All our time bounds improve previous bounds.
Improving structural similarity based virtual screening using background knowledge
2013
Background Virtual screening in the form of similarity rankings is often applied in the early drug discovery process to rank and prioritize compounds from a database. This similarity ranking can be achieved with structural similarity measures. However, their general nature can lead to insufficient performance in some application cases. In this paper, we provide a link between ranking-based virtual screening and fragment-based data mining methods. The inclusion of binding-relevant background knowledge into a structural similarity measure improves the quality of the similarity rankings. This background knowledge in the form of binding relevant substructures can either be derived by hand selec…
Knowledge and Beliefs About Developmental Dyslexia: A Comparison Between Pre-Service and In-Service Peruvian Teachers
2017
The purpose of this study was to investigate the knowledge, misconceptions, and knowledge gaps of Peruvian pre-service teachers (PSTs) and in-service teachers (ISTs). To do so, 112 PSTs and 113 ISTs completed the Knowledge and Beliefs About Developmental Dyslexia Scale (KBDDS). Results show that ISTs scored significantly higher than PSTs. Moreover, misconceptions and lack of information were higher in PSTs. The most noteworthy misconceptions were that dyslexia is due to poor visual perception and that letter or word reversals are the most important criterion in the identification of dyslexia. Age, years of teaching experience, prior exposure to a child with dyslexia, and self-efficacy were …
The Role of Vitamin Deficiency in Liver Disease: To Supplement or Not Supplement?
2021
Over the past few years, growing interest has been shown for the impact of dietary requirements and nutritional factors on chronic diseases. As a result, nutritional programs have been reinforced by public health policies. The precise role of micronutrients in chronic liver disease is currently receiving particular attention since abnormalities in vitamin levels are often detected. At present, treatment programs are focused on correcting vitamin deficiencies, which are frequently correlated to higher rates of comorbidities with poor outcomes. The literature reviewed here indicates that liver diseases are often related to vitamin disorders, due to both liver impairment and abnormal intake. M…