Search results for "efficacy"
showing 10 items of 588 documents
Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: results from the Italian Psocare registry
2014
Background: Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. Objective: We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discontinuing the first TNF-alfa inhibitor. Methods: Data from all 5423 consecutive patients starting TNF-alfa inhibitor therapy for psoriasis between September 2005 and September 2010 who were included in the Italian Psocare registry were analyzed. Results: In 105 patients who switched to a second TNF-alfa inhibitor who had complete follow-up data, 75% improvement in the Psoriasis …
Drug‐refractory myasthenia gravis: Clinical characteristics, treatments, and outcome
2022
[Objective] To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment.
Efficacy of pneumatic dilatation for the treatment of idiopatic achalasia: a single-center experience
2015
Pneumatic dilatation (PD) and Surgical Miotomy (SM) are presently the best treatments for untreated achalasia, with similar efficacy. There is no information on the relative efficacy of PD in younger compared to older patients. Aim of our study was to compare success rate and safety of PD in patients under fifty years old and in those over fifty years old affected by achalasia. Twenty consecutive symptomatic patients were treated in our Unit with graded PD under fluoroscopic view. Five male and 15 female with a median age of 47 years were treated. Twelve patients were less than fifty years old (group I) while 8 were older (group II). Median dysphagia questionnaire score was 14 and13 ingroup…
Reward crowdfunding contribution as planned behaviour: An extended framework
2019
Published by Elsevier Inc. This is an open access article under the CC BY license. Reward crowdfunding is a popular channel for entrepreneurial fundraising, whereby backers receive non-monetary benefits in return for monetary contributions while accepting risks of non-delivery on campaign pitch promises. To understand contribution behavior in this context, we apply the Theory of Planned Behavior (TPB) for analyzing contribution intentionality and behavior, as well as their antecedents. We use survey data from 560 users of Finland's leading reward crowdfunding platform– Mesenaatti. Our findings show that an extended TPB model holds for reward crowdfunding and that both financial-contribution…
Optimization of electrospun polylactide-based ultrathin fibers for osteoconductive bone scaffolds
2011
Bone tissue interfacial scaffolds, which encourage cell growth, are critical determinants for clinical success after implant surgery. Over the years, a number of resorbable configurations have emerged for bone cell support and growth, but only a few have demonstrated clinical efficacy. Polymer coatings produced by electrospinning are regarded as very promising bone interfaces because of the ultrathin-scaled dimensions of its physical structure. In this study, the morphology, composition, thermal properties, and cell growth viability of a number of polylactide-based systems containing different binary and ternary formulations of this biomaterial with collagen and commercial hydroxyapatite na…
La fabrication des artisans : socialisation et processus de médiation dans l'apprentissage de la menuiserie
2012
This doctoral thesis in Communication Sciences offers to rethink the question of transmission of manual trades, in the context of contemporary craft industry in France. We analyse the classical dualism between “manual” and “nonmanual”, and go further with a theoretical approach of intelligence derived from Janet and Jousse. We also base our analysis on the studies about socialization, especially from Dubar, so we can involve a non-determinist model of transmitting manual crafts. In order to recognize the importance of working with materials, tools, in occupational socialization, we propose to look at its sequence as a “process of mediation” and to describe its communication device, inspired…
Impact of Adolescents' Perceived Self-Regulatory Efficacy on Familial Communication and Antisocial Conduct
1998
The present study tested the hypothesis that perceived self-efficacy to resist peer pressure for high-risk activities is related to transgressive conduct, both directly and through the mediation of open familial communication. Adolescents rated their self-regulatory efficacy, openness of communication with parents, and their involvement in delinquent conduct and substance abuse. Results of structural equation modeling confirmed that a high sense of efficacy to ward off negative peer influences was accompanied by open communication with parents about activities outside the home and by low engagement in delinquent conduct and substance abuse. Both the posited direct and mediated paths of inf…
Safety self-efficacy and internal locus of control as mediators of safety motivation – Randomized controlled trial (RCT) study
2019
Abstract Behavioral factors play a fundamental role in preventing occupational injuries and accidents. Previous studies have shown that engagement in safety behavior is influenced by workers’ safety motivation. However, understanding of the cognitive factors that contribute to safety motivation is lacking. In this study, we examine internal safety locus of control and safety self-efficacy as mediators of the effects of a safety intervention on safety motivation. In 2016, 464 students from eight vocational schools participated in a school-based cluster randomized, controlled intervention study conducted in Finland. In the multiple mediation model investigated using structural equation modeli…
Comparative effects of carrier proteins on vaccine-induced immune response
2011
The efficacy of vaccines against major encapsulated bacterial pathogens -Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b (Hib) - has been significantly enhanced by conjugating the respective polysaccharides with different carrier proteins: diphtheria toxoid; non-toxic cross-reactive material of diphtheria toxin(197), tetanus toxoid, N. meningitidis outer membrane protein, and non-typeable H. influenzae-derived protein D. Hib, meningococcal, and pneumococcal conjugate vaccines have shown good safety and immunogenicity profiles regardless of the carrier protein used, although data are conflicting as to which carrier protein is the most immunogenic. Coadmini…
Anodal tDCS over the left prefrontal cortex does not cause clinically significant changes in circulating metabolites
2020
Background: Transcranial direct current stimulation (tDCS), a putative treatment for depression, has been proposed to affect peripheral metabolism. Metabolic products from brain tissue may also cross the blood–brain barrier, reflecting the conditions in the brain. However, there are no previous data regarding the effect of tDCS on circulating metabolites.\ud Objective: To determine whether five daily sessions of tDCS modulate peripheral metabolites in healthy adult men.\ud Methods: This double-blind, randomized controlled trial involved 79 healthy males (aged 20–40 years) divided into two groups, one receiving tDCS (2 mA) and the other sham stimulated. The anode was placed over the left dor…