Search results for "element"
showing 10 items of 13601 documents
On the severity of aortic stenosis in ascending aortic aneurysm: A computational tool to examine ventricular-arterial interaction and aortic wall str…
2020
Abstract An ascending thoracic aortic aneurysm (ATAA) is a life-threatening cardiovascular consequence of vessel dilatation that portends adverse events and death. From a clinical perspective, ATAA should not be treated as an isolated disease, and surgery is often carried out in the presence of AS, aortic insufficiency or a calcified valve leaflet. Aortic stenosis (AS) is common in ATAAs and leads to both vessel rigidity and left ventricular (LV) impairment. In this study, lumped-parameter modeling and computational analysis were used to assess the change in the wall shear stress (WSS) and intramural wall stress of patient-specific ATAA models with different degrees of AS (i.e., mild to sev…
Constitutive modeling of ascending thoracic aortic aneurysms using microstructural parameters.
2016
Ascending thoracic aortic aneurysm (ATAA) has been associated with diminished biomechanical strength and disruption in the collagen fiber microarchitecture. Additionally, the congenital bicuspid aortic valve (BAV) leads to a distinct extracellular matrix structure that may be related to ATAA development at an earlier age than degenerative aneurysms arising in patients with the morphological normal tricuspid aortic valve (TAV). The purpose of this study was to model the fiber-reinforced mechanical response of ATAA specimens from patients with either BAV or TAV. This was achieved by combining image-analysis derived parameters of collagen fiber dispersion and alignment with tensile testing dat…
Clinical Use of Oxygen Stores: Pre-oxygenation and Apneic Oxygenation
1992
During states of respiratory arrest the human oxygen stores may be used therapeutically, regardless of the origin, i.e. either prior to the routinely induced apnea for endotracheal intubation or as an emergency measure in any other case of apnea. The present considerations focus on the clinical use of the oxygen stores available, applying.
Reduced VLDL clearance in ApoeNpc1 mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels
2010
Niemann-Pick type C1 (NPC1) promotes the transport of LDL receptor (LDL-R)-derived cholesterol from late endosomes/lysosomes to other cellular compartments. NPC1-deficient cells showed impaired regulation of liver_X receptor (LXR) and sterol regulatory element-binding protein (SREBP) target genes. We observed that Apoe(-/-)Npc1(-/-) mice displayed a marked increase in total plasma cholesterol mainly due to increased VLDL, reflecting decreased clearance. Although nuclear SREBP-2 and Ldlr mRNA levels were increased in Apoe(-/-)Npc1(-/-) liver, LDL-R protein levels were decreased in association with marked induction of proprotein convertase subtilisin/kexin type 9 (Pcsk9) and inducible degrade…
Closed form coefficients in the Symmetric Boundary Element Approach
2006
Abstract In the area of the structural analysis, the problems connected to the use of the symmetric Galerkin Boundary Element Method (SGBEM) must be investigated especially in the mathematical and computational difficulties that are present in computing the solving system coefficients. Indeed, any coefficient is made by double integrals including often fundamental solutions having a high degree of singularity. Therefore, the related computation proves to be difficult in the solution. This paper suggests a simple computation technique of the coefficients obtained in closed form. Using a particular matrix, called ‘progenitor’ matrix [Panzeca T, Cucco F, Terravecchia S. Symmetric boundary elem…
A boundary min-max principle as a tool for boundary element formulations
1991
Abstract A min-max principle for elastic solids, expressed in terms of the unknown boundary displacements and tractions, is presented. It is shown that its Euler-Lagrange equations coincide with the classical boundary integral equations for displacements and for tractions. This principle constitutes a suitable starting point for a symmetric sign-definite formulation of the boundary element method.
Nonlocal elasticity and related variational principles
2001
Abstract The Eringen model of nonlocal elasticity is considered and its implications in solid mechanics studied. The model is refined by assuming an attenuation function depending on the `geodetical distance' between material particles, such that in the diffusion processes of the nonlocality effects certain obstacles as holes or cracks existing in the domain can be circumvented. A suitable thermodynamic framework with nonlocality is also envisaged as a firm basis of the model. The nonlocal elasticity boundary-value problem for infinitesimal displacements and quasi-static loads is addressed and the conditions for the solution uniqueness are established. Three variational principles, nonlocal…
Internal fe approximation of spaces of divergence-free functions in three-dimensional domains
1986
SUMMARY The space of divergence-free vector functions with vanishing normal flux on the boundary is approximated by subspaces of finite elements having the same property. An easy way of generating basis functions in these subspaces is shown.
On the Computational Aspects of a Symmetric Multidomain Boundary Element Method Approach for Elastoplastic Analysis
2011
The symmetric boundary element method (SBEM) is applied to the elasto-plastic analysis of bodies subdivided into substructures. This methodology is based on the use of: a multidomain SBEM approach, for the evaluation of the elastic predictor; a return mapping algorithm based on the extremal paths theory, for the evaluation of inelastic quantities characterizing the plastic behaviour of each substructure; and a transformation of the domain inelastic integrals of each substructure into corresponding boundary integrals. The elastic analysis is performed by using the SBEM displacement approach, which has the advantage of creating system equations that only consist of nodal kinematical unknowns…
Domain decomposition in the symmetric boundary element analysis
2002
Recent developments in the symmetric boundary element method (SBEM) have shown a clear superiority of this formulation over the collocation method. Its competitiveness has been tested in comparison to the finite element method (FEM) and is manifested in several engineering problems in which internal boundaries are present, i.e. those in which the body shows a jump in the physical characteristics of the material and in which an appropriate study of the response must be used. When we work in the ambit of the SBE formulation, the body is subdivided into macroelements characterized by some relations which link the interface boundary unknowns to the external actions. These relations, valid for e…