Search results for "endocrine disruptor"
showing 10 items of 74 documents
Prenatal exposure to mixtures of xenoestrogens and repetitive element DNA methylation changes in human placenta
2014
BACKGROUND: Prenatal exposure to endocrine disrupting compounds (EDCs) has previously shown to alter epigenetic marks. OBJECTIVES: In this work we explore whether prenatal exposure to mixtures of xenoestrogens has the potential to alter the placenta epigenome, by studying DNA methylation in retrotransposons as a surrogate of global DNA methylation. METHODS: The biomarker total effective xenoestrogen burden (TEXB) was measured in 192 placentas from participants in the longitudinal INMA Project. DNA methylation was quantitatively assessed by bisulfite pyrosequencing on 10 different retrotransposons including 3 different long interspersed nuclear elements (LINEs), 4 short interspersed nuclear …
Fate of endocrine disruptor compounds in an anaerobic membrane bioreactor (AnMBR) coupled to an activated sludge reactor
2018
[EN] The occurrence and fate of three groups of micropollutants - alkylphenols, pentachlorophenol and hormones - were studied in a pilot plant consisting of an anaerobic membrane bioreactor (AnMBR) coupled to an activated sludge reactor (University of Cape Town configuration - UCT). Under anaerobic conditions, the octylphenol and technical-nonylphenol soluble concentrations increased producing negative degradation ratios (i.e., -175 and -118%, respectively). However, high 4-n-nonylphenol and bisphenol-A degradation ratios (92 and 59% for 4-n-nonylphenol and bisphenol-A, respectively) as well as complete pentachlorophenol, estrone, 17 beta-estradiol and 17 alpha-ethinylestradiol removal were…
Removal and fate of endocrine disruptors chemicals under lab-scalepostreatment stage. Removal assessment using light, oxygen and microalgae
2013
[EN] The aim of this study was to assess the effect of light, oxygen and microalgae on micropollutants removal. The studied micropollutants were 4-(1,1,3,3-tetramethylbutyl)phenol (OP), technical-nonylphenol (t-NP), 4-n-nonylphenol (4-NP), Bisphenol-A (BPA). In order to study the effect of the three variables on the micropollutants removal, a factorial design was developed. The experiments were carried out in four batch reactors which treated the effluent of an anaerobic membrane bioreactor. The gas chromatography mass spectrometry was used for the measurement of the micropollutants. The results showed that light, oxygen and microalgae affected differently to the degradation ratios of each …
Simulated solar UV-irradiation of endocrine disrupting chemical octylphenol.
2009
The photolysis of octylphenol (OP) was investigated using a solar simulator in the absence/presence of dissolved natural organic matter (DNOM), HCO(3)(-), NO(3)(-) and Fe(III) ions. The effects of different parameters such as initial pH, initial concentration of substrate, temperature, and the effect of hydrogen peroxide concentration on photodegradation of octylphenol in aqueous solution have been assessed. The results indicate that the oxidation rate increases in the presence of H(2)O(2), nitrate and DNOM. Phenol, 1,4-dihydroxylbenzene and 1,4-benzoquinone were identified as intermediate products of photodegradation of octylphenol, through an HPLC method. In addition, the disappearance of…
A validated search filter for the identification of endocrine disruptors based on the ECHA/EFSA guidance recommendations.
2020
Abstract A guidance document for the identification of endocrine disruptors (EDs) in the regulatory assessment of plant protection products (PPP) and biocidal products (BP) has been published by the European Chemical Agency (ECHA) and the European Food Safety Authority (EFSA). The ECHA/EFSA guidance, mainly addressing EATS (estrogen, androgen, thyroid, steroidogenesis) modalities, is intended to guide applicants and assessors of the competent regulatory authorities on the implementation of the scientific criteria for the determination of ED properties pursuant to the recently implemented PPP ( EU 2018/605 ) and BP ( EU 2017/2100 ) EU Regulations. In this study, a search filter for targeted …
Determination of Selected Phthalates by Gas Chromatography–Mass Spectrometry in Personal Perfumes
2015
A simple and fast method is proposed to analyze commercial personal perfumes. Our method includes measurement of phthalates, known to be major sources of endocrine disruptor chemicals (EDC), which originate from the less volatile fraction of perfumes. The quantification of phthalates were carried out directly with no sample preparation required on 30 samples of commercial products using gas chromatography and mass spectrometry (GC-MS) as a detector. The total concentrations of 15 investigated compounds ranged from 17 to 9650 mg/L with an average of 2643 mg/L. The highest total concentration was found in cologne. Diethyl phthalate (DEP), diisobutyl phthalate (DiBP), di(2-ethylhexyl) phthalat…
Contaminants of emerging concern in freshwater fish from four Spanish Rivers.
2019
This study investigated the occurrence of 135 contaminants of emerging concern (CECs) – pharmaceuticals, pesticides, a set of endocrine disrupting compounds (EDCs) (parabens, bisphenols, hormones, triazoles, organophosphorus flame retardants and triclosan), UV-filters, perfluoroalkyl substances (PFASs) and halogenated flame retardants (HFRs) – in 59 fish samples, collected in 2010 in 4 Spanish Rivers (Guadalquivir, Júcar, Ebro and Llobregat). Of the 135 CECs, 76 including 8 pharmaceuticals, 25 pesticides, 10 EDCs, 5 UV-filters, 15 PFASs and 13 HFRs were detected. Pharmaceuticals were the less frequently found and at lower concentrations. Pesticides, EDCs, UV-filters, PFASs and HFRs were det…
Assessment of ecotoxicity and total volatile organic compound (TVOC) emissions from food and children's toy products
2018
The development of new methods for identifying a broad spectrum of analytes, as well as highly selective tools to provide the most accurate information regarding the processes and relationships in the world, has been an area of interest for researchers for many years. The information obtained with these tools provides valuable data to complement existing knowledge but, above all, to identify and determine previously unknown hazards. Recently, attention has been paid to the migration of xenobiotics from the surfaces of various everyday objects and the resulting impacts on human health. Since children are among those most vulnerable to health consequences, one of the main subjects of interest…
Micropollutants removal in an anaerobic membrane bioreactor and in an aerobic conventional treatment plant
2012
The paper expresses an attempt to tackle the problem due to the presence of micropollutants in wastewater which may be able to disrupt the endocrine system of some organisms. These kinds of compounds are ubiquitously present in municipal wastewater treatment plant (WWTP) effluents. The aim of this paper is to compare the fate of the alkylphenols-APs (4-(tert-octyl)) phenol, t-nonylphenol and 4-p-nonylphenol and the hormones (estrone, 17ß-estradiol and 17¿-ethinylestradiol) in a submerged anaerobic membrane bioreactor (SAMBR) pilot plant and in a conventional activated sludge wastewater treatment plant (CTP). The obtained results are also compared with the results obtained in a previous stud…
In silico methods for metabolomic and toxicity prediction of zearalenone, α-zearalenone and β-zearalenone.
2020
Zearalenone (ZEA), α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL) (ZEA's metabolites) are co/present in cereals, fruits or their products. All three with other compounds, constitute a cocktail-mixture that consumers (and also animals) are exposed and never entirely evaluated, nor in vitro nor in vivo. Effect of ZEA has been correlated to endocrine disruptor alterations as well as its metabolites (α-ZEL and β-ZEL); however, toxic effects associated to metabolites generated once ingested are unknown and difficult to study. The present study defines the metabolomics profile of all three mycotoxins (ZEA, α-ZEL and β-ZEL) and explores the prediction of their toxic effects proposing an in silico w…