Search results for "endocrine"
showing 10 items of 2114 documents
Coarse-Graining Intermolecular Interactions in Dispersions of Highly Charged Colloids
2012
International audience; Effective pair potentials between charged colloids, obtained from Monte Carlo simulations of two single colloids in a closed cell at the primitive model level, are shown to reproduce accurately the structure of aqueous salt-free colloidal dispersions, as determined from full primitive model simulations by Linse et al. (Linse, P.; Lobaskin, V. Electrostatic Attraction and Phase Separation in Solutions of Like-Charged Colloidal Particles. Phys. Rev. Lett.1999, 83, 4208). Excellent agreement is obtained even when ion-ion correlations are important and is in principle not limited to spherical particles, providing a potential route to coarse-grained colloidal interactions…
Retinoids as a Perspective in Treatment of Alzheimer’s Disease
2010
<i>Background:</i> In the past, we demonstrated that the disintegrin metalloproteinase ADAM10 has α-secretase activity in vitro and in cultured cells. We also found out that moderate overexpression of this proteinase inhibits Aβ peptide production and prevents the formation of amyloid plaques in an Alzheimer’s disease (AD) mouse model. Moreover, it corrects early hippocampal defects like LTP impairment and increases cortical synaptogenesis. <i>Objective:</i> Upregulation of ADAM10 might be an alternative approach concerning AD therapy. Our current research therefore focuses on substances and/or pathways which regulate ADAM10 gene expression. <i>Methods:</i&g…
Control of Morphology and Corona Composition in Aggregates of Mixtures of PS-b-PAA and PS-b-P4VP Diblock Copolymers: Effects of Solvent, Water Conten…
2014
The morphologies and corona compositions in aggregates of mixtures of PS-b-PAA and PS-b-P4VP diblock copolymers are influenced by controllable assembly parameters such as water content, block copolymer molar ratios, and solvent effects as well as the hydrophilic block lengths and block length ratios. All these factors can affect the morphology of the aggregates as well as their corona composition, the latter especially in vesicles, where two interfaces are involved. The morphologies and corona compositions of the aggregates were investigated by transmission electron microscopy and electrophoretic mobility, respectively. They depend, to a large extent, on the solubility of P4VP and PAA in th…
Control of Corona Composition and Morphology in Aggregates of Mixtures of PS-b-PAA and PS-b-P4VP Diblock Copolymers: Effects of pH and Block Length
2014
The corona compositions and morphologies in aggregates of mixtures of amphiphilic polystyrene-block-poly(acrylic acid) (PS-b-PAA) and polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) diblock copolymers are influenced by controllable assembly parameters such as the hydrophilic block length and solution pH. The morphologies and corona compositions of the aggregates were investigated by transmission electron microscopy and electrophoretic mobility, respectively. When mineral acids or bases are present during aggregate formation, they can exert a strong influence on the corona composition. Morphology changes were also seen with changing pH, as well as changes in corona composition, specifica…
The Trumorph℗® system: The new univ the morphology of living sperm
2015
Abstract Evaluation of sperm morphology is a fundamental component of semen analysis, but its real significance has been obscured by a plethora of techniques that involve fixation and staining procedures that induce artefacts. Here we describe Trumorph℗ ® , a new method for sperm morphology assesment that is based upon examination of wet preparations of living spermatozoa immobilized by a short 60 °C shock using negative phase contrast microscopy. We have observed samples from five animals of the following species: bull, boar, goat and rabbit. In every case, all the components of the sperm head and tail were perfectly defined, including the acrosome and midpiece (in all its length, includin…
Sugar moiety has a direct influence on the secondary structure and properties of sturgeon gonadotropin
2009
Sugar moiety has a direct influence on the secondary structure and properties of sturgeon gonadotropin Sturgeon Acipenser güldenstädti Br. gonadotropic hormone (GTH) β-subunit (β-GTH) was selectively chemically deglycosylated (dg) by anhydrous hydrogen fluoride and trifluoromethane sulfonic acid. Two dgβ-GTH molecular forms retaining 35% (dgβ-GTH1) and 13% (dgβ-GTH2) of their initial carbohydrates were obtained. Investigation of the reassociated α-β hybrid dimers (recombinants) α-GTH+dgβ-GTH1 and α-GTH+dgβ-GTH2 showed that the immunoreactivity with antiserum raised against standard GTH dropped by 22.5%. Hybrid dimers were recognised by the standard GTH antibodies, which indicated that the s…
"Table 110" of "Measurements of $t\bar{t}$ differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in $pp$ col…
2019
$|{\cos{\theta}^{\star}}|$ normalized differential cross-section at parton level. The parton level phase-space is limited to the region $p_T^{t,1} > 500~$GeV, $p_T^{t,2} > 350~$GeV.
"Table 170" of "Measurements of $t\bar{t}$ differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in $pp$ col…
2018
${cos{\theta}^{\star}}$ correlation matrix for relative differential cross-section in parton level
"Table 168" of "Measurements of $t\bar{t}$ differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in $pp$ col…
2018
${cos{\theta}^{\star}}$ correlation matrix for absolute differential cross-section in parton level
"Table 169" of "Measurements of $t\bar{t}$ differential cross-sections of highly boosted top quarks decaying to all-hadronic final states in $pp$ col…
2018
${cos{\theta}^{\star}}$ covariance matrix for relative differential cross-section in parton level