Search results for "endocrine"

Environmental Aspect Concerning Phthalates Contamination: Analytical Approaches and Assessment of Biomonitoring in the Aquatic Environment

2023

This review is a survey of recent progress in studies concerning the impact of phthalic acid esters in aquatic organisms. After introducing the classification, properties, sources, fate, and toxic effects related to phthalates, an overview of the techniques of extraction and analysis of these substances is provided. As a result, the general concepts of environmental bioindicators, biomonitoring systems, and other concepts related to phthalate contamination in the aquatic environment are presented. Recent bioaccumulation data of different phthalates are summarised in a table and organised according to the type of organism, tissue, and geographical area of sampling. Bioindicator organisms tha…

Endocrine disrupters: the new players able to affect the epigenome

2015

Epigenetics represents the way by which the environment is able to program the genome; there are three main levels of epigenetic control on genome: DNA methylation, post-translational histone modification and microRNA expression. The term Epigenetics has been widened by NIH to include “both heritable changes in gene activity and expression but also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable.” These changes might be produced mostly by the early life environment and might affect health influencing the susceptibility to develop diseases, from cancer to mental disorder, during the entire life span. The most studied environmental i…

Elaboration of a list of substances of interest as regards to a potential endocrine activity and prioritisation strategy for assessment

2021

Endocrine Disruptor Chemicals (EDCs) are substances that alter function(s) of the endocrine system and consequently cause adverse health effects. The endocrine system consists of many cells and tissues that interact with each other and the rest of the body by means ofhormones. This system is responsible for controlling a large number of processes in the body from gamete formation, to conception and early developmental processes such as organogenesis, and to most tissue and organ functions throughout life. EDCs interfere withendocrine function by many ways and, in doing so, lead to adverse effects on the health of humans and/or wildlife. Some of the observed health effects associated with ED…

Kinetics of Renal Function during Induction in Newly Diagnosed Multiple Myeloma: Results of Two Prospective Studies by the German Myeloma Study Group…

2021

Background: Preservation of kidney function in newly diagnosed (ND) multiple myeloma (MM) helps to prevent excess toxicity. Patients (pts) from two prospective trials were analyzed, provided postinduction (PInd) restaging was performed. Pts received three cycles with bortezomib (btz), cyclophosphamide, and dexamethasone (dex

Editorial: Emerging Chemical Risks for Human Health: Endocrine Disruption by Per- and Poly-Fluorinated Alkyl Substances (PFAS).

2021

Risposte endocrine ed immunitarie in calciatori professionisti dopo allenamento e competizione ufficiale

2002

Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea

2019

Background: Thyroid cancer has become the most common cancer in Korea. Generally, thyroid cancer patients have a good prognosis; however, 15–20% of patients experience recurrence or distant metastasis or are refractory to standard treatment. We assessed the safety of sorafenib and lenvatinib in patients with advanced or metastatic radioactive iodine-refractory differentiated thyroid cancers (DTC) consecutively treated at a tertiary center in South Korea.Methods: We retrospectively reviewed the charts of all consecutive patients with DTC treated during ≥6 months with lenvatinib (February 2016–April 2018) and sorafenib (January 2014–April 2018) at Gangnam Severance Hospital. Patients were tre…

Expression of ?-catenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland : An immunohistochemical study

2006

Objetives. Pleomorphic adenomas are the most frequent type of epithelial salivary gland neoplasms, and their malignant counterpart, the carcinoma in pleomorphic adenomas, is much less common. ?-catenin is a cell adhesion molecule associated with the invasion and metastasis of carcinomas of the head and neck, esophagus. The objective of this study was to detect the expression of ?-catenin in pleomorphic adenomas, carcinomas in pleomorphic adenomas and normal salivary glands to discuss its role in the development of these two lesions. Study Design. The expression of ?-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by …

Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review

2019

The essential amino acid L-tryptophan (Trp) is the precursor of the monoaminergic neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Numerous studies have shown that elevated dietary Trp has a suppressive effect on aggressive behavior and post-stress plasma cortisol concentrations in vertebrates, including teleosts. These effects are believed to be mediated by the brain serotonergic system, even though all mechanisms involved are not well understood. The rate of 5-HT biosynthesis is limited by Trp availability, but only in neurons of the hindbrain raphe area predominantly expressing the isoform TPH2 of the enzyme tryptophan hydroxylase (TPH). In the periphery as well as in brain areas …

Acute Neuromuscular and Hormonal Responses to Power, Strength, and Hypertrophic Protocols and Training Background

2022

This study investigated how two slightly different athlete groups would differ in acute neuromuscular and endocrine responses to specific resistance exercise loadings and recovery compared to untrained participants. Power athletes (PA, n = 8), strength athletes (SA, n = 8) and non-athletes (NA, n = 7) performed power (PL, 7 × 6 × 50% of 1RM), maximal strength (MSL, 7 × 3 × 3RM), and hypertrophic (HL, 5 × 10 × 10RM) loadings in Smith-machine back-squat. Neuromuscular performance, serum testosterone, growth hormone, and cortisol concentrations, and blood lactate (BL) were measured before (Pre), at Mid and after (Post) loading, and after recovery for 24 and 48 h. All loadings led to acute decr…