Search results for "energi"
showing 10 items of 1725 documents
Changes in Adrenoceptors and G-Protein-Coupled Receptor Kinase 2 in <smlcap>L</smlcap>-NAME-Induced Hypertension Compared to Spontaneous …
2014
This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance (aorta) and resistance vessels (mesenteric resistance arteries; MRA) in two different models of rat hypertension: hypertension induced by chronic treatment with <smlcap>L</smlcap>-NAME (N<sup>G</sup>-nitro-<smlcap>L</smlcap>-arginine methyl-ester) (<smlcap>L</smlcap>-NAME-treated rats; LNHR), and genetically induced hypertension (spontaneously hypertensive rats; SHR). Changes found in the aorta, but not in the MRA, were: (1) a loss of contractile capacity, more evidently in α…
Opposite vascular activity of (R)-apomorphine and its oxidised derivatives. Endothelium-dependent vasoconstriction induced by the auto-oxidation meta…
2003
We have synthetised a series of oxidised apomorphine derivatives (orto and para quinones 2-5), in order to analyse their vascular activity. We have performed radioligand binding assays on rat cortical membranes and functional studies on rat aortic rings. Instead the relaxant activity exhibited by (R)-apomorphine, o-quinones 2, 4, show contractile activity dependent on endothelium in rat aortic rings. Compound 2, the main metabolite of (R)-apomorphine auto-oxidation, was the product which showed enhanced contractile activity by a complex mechanism related to activation of Ca(2+) channels through release and/or inhibition of endothelial factors. Moreover, this compound disrupts the endothelia…
Vascular Activity of (-)-Anonaine, (-)-Roemerine and (-)-Pukateine, Three Natural 6a(R)-1,2-Methylenedioxyaporphines with Different Affinities for α1…
2004
We have studied the mechanism of action of three 6a( R)-1,2-methylenedioxyaporphines as vasorelaxant compounds. The alkaloids assayed showed different affinities for the three human cloned alpha (1)-adrenoceptor (AR) subtypes stably expressed in rat-1 fibroblasts, showing lower affinity for alpha(1B)-AR with regard to the alpha(1A)- or alpha(1D)-subtypes. These three natural compounds are more potent inhibitors of [ (3)H]-prazosin binding than of [ (3)H]-diltiazem binding to rat cerebral cortical membranes. As all these alkaloids inhibited noradrenaline (NA)-induced [ (3)H]-inositol phosphate formation in cerebral cortex and rat tail artery, they may be safely viewed as alpha (1)-AR antagon…
A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype.
1996
1. The selectivity of action of boldine and the related aporphine alkaloids, predicentrine (9-O-methylboldine) and glaucine (2,9-O-dimethylboldine) and alpha 1-adrenoceptor subtypes was studied by examining [3H]-prazosin competition binding in rat cerebral cortex. WB 4101 and benoxathian were used as selective alpha 1A-adrenoceptor antagonists. 2. In the competition experiments [3H]-prazosin (0.2 nM) binding was inhibited by WB 4101 and benoxathian. The inhibition curves displayed shallow slopes which could be subdivided into high and low affinity components (pKi = 9.92 and 8.29 for WB 4101, 9.35 and 7.94 for benoxathian). The two antagonists recognized approximately 37% of the sites with h…
Energy management of multi-carrier smart buildings for integrating local renewable energy systems
2016
The proposed paper aims at defining a Building Management System (BMS) able to control energy flows inside a smart building integrated with various energy networks and Renewable Energy Resources (RES). The smart building envisaged in this work interacts with different energy carriers and is equipped with cogeneration and RES systems, as well as storage devices, which enable a certain degree of flexibility in the energy usage. The smart building is modelled as a multi-carrier hub, by defining the graphical and mathematical model of the building system. Moreover, the control criteria of the BMS are explained and the implementation of the BMS itself is depicted, along with some early results. …
A laboratory setup for the evaluation of the effects of BACS and TBM systems on lighting
2015
The paper focuses on the evaluation of the impact of Building Automation Control Systems (BACS) and Technical Building Management (TBM) systems on the performance of the lighting system in a residential building. In particular, this work shows a laboratory setup, installed at the DEIM of the University of Palermo, for simulating a typical apartment. The paper describes the laboratory, the lighting system and the BAC system installed and the test facility for evaluating the electricity consumption in presence and in absence of automation. The laboratory has been built within a research project funded by the Italian Minister of University and Research in the framework of the PON Smart Cities …
Multi-objective optimization of building life cycle performance. A housing renovation case study in Northern Europe
2020
While the operational energy use of buildings is often regulated in current energy saving policies, their embodied greenhouse gas emissions still have a considerable mitigation potential. The study aims at developing a multi-objective optimization method for design and renovation of buildings incorporating the operational and embodied energy demands, global warming potential, and costs as objective functions. The optimization method was tested on the renovation of an apartment building in Denmark, mainly focusing envelope improvements as roof and exterior wall insulation and windows. Cellulose insulation has been the predominant result, together with fiber cement or aluminum-based cladding …
Economic Feasibility of Measures for Energy Efficiency
2014
In this chapter the economic impact of some measures for energy efficiency, both using automation of technical infrastructures (according to EN 15232) as well as implementing passive measures concerning the use of building materials and techniques (according to EN 15271), is studied. The chapter is organized as follows. First, a technical-economical study on the evaluation of the impact on residential buildings of Building Automation Control, BAC, and Technical Building Management, TBM, systems is presented. Then the same assessment of some passive measures that can be employed is carried out using the Passive House Standard for Mediterranean warm climates is shown. Numerical elaborations h…
Acciones para mejorar la eficiencia energética en los edificios en Europa: estado del arte sobre los standards técnicos
2022
The paper is aimed at reviewing the state of the art of the European technical normative implementation during the last decades concerning the building energy efficiency. Indeed, it is well acknowledged that the present building stock is largely obsolete and inefficient: in the European context alone, around 75% of the buildings is not energy efficient and most are expected to be in use until 2050. Consequently, buildings require not only a general rehabilitation, to extend, or even avoid, its end-of-life time, but also a complete afterthought of their energy performance. That is extremely urgent to improve the overall sustainability of the construction sector that, alone, is one of the mai…