Search results for "eps"

Former des conseillers pédagogiques du premier degré par la recherche.

2008

Cette recherche-formation visait à mettre en évidence le contenu et la forme des entretiens menés par des conseillers pédagogiques du premier degré au cours de leurs visites auprès de professeurs des écoles pour faire évoluer leurs pratiques. De nombreuses transformations ont été identifiées à partir d’un questionnaire, surtout au niveau de l’écoute et de la place qui est laissée aux formés. La plus grande évolution s’est opérée au plan de la posture avec une prise en compte plus importante de l’Autre en tant que sujet et acteur de sa formation dans différents registres. The aim of this training-research was to bring out the content and form of interviews led by educational advisers during …

L'analyse des pratiques d'enseignement de l'EPS, les outils utilisés par les chercheurs et les formateurs

2006

Le praticien réflexif débutant en EPS. Nature et évolution de cette réflexivité. Communication orale. AIESEP séminaire international

2009

L’influence des institutions internationales dans l’histoire récente de l’EPS en France

2011

International audience

Oppiminen ja asiantuntijuus varhaiskasvatuksessa : varhaisen oppimaan ohjaamisen suunnitelma erityistä tukea tarvitsevien lasten ohjauksessa

2004

Ventilatory chemosensitivity, cerebral and muscle oxygenation, and total hemoglobin mass before and after a 72-day mt. Everest expedition.

2014

Abstract. Cheung, Stephen S, Niina E. Mutanen, Heikki M. Karinen, Anne S. Koponen, Heikki Kyro ̈ la ̈ inen, Heikki O. Tikkanen, and Juha E. Peltonen. Ventilatory chemosensitivity, cerebral and muscle oxygenation, and total hemoglobin mass before and after a 72-day Mt. Everest expedition. High Alt Med Biol 15:331–340, 2014.— Background: We investigated the effects of chronic hypobaric hypoxic acclimatization, performed over the course of a 72-day self-supported Everest expedition, on ventilatory chemosensitivity, arterial saturation, and tissue oxygenation adaptation along with total hemoglobin mass (tHb-mass) in nine experienced climbers (age 37 – 6 years, _ VO 2peak 55 – 7mL $ kg - 1 $ min…

Desarrollo de sistemas mesoporosos con puertas moleculares para el transporte y la liberación selectiva y controlada de fármacos

2019

La presente tesis doctoral titulada “Desarrollo de sistemas mesoporosos con puertas moleculares para el transporte y la liberación selectiva y controlada de fármacos” se centra en la síntesis de materiales híbridos orgánico-inorgánicos. Estos materiales están compuestos por un material mesoporoso inorgánico que actúa como reservorio (en el cual introducir un colorante o un fármaco) y por una puerta molecular, que es una estructura química de naturaleza orgánica que permite la liberación selectiva y controlada de las moléculas presentes en el interior de las partículas porosas, y que puede adoptar dos posiciones, abierta o cerrada, siendo el cambio de estado inducido por un estímulo externo.…

Dipeptide analogues of fluorinated aminophosphonic acid sodium salts as moderate competitive inhibitors of cathepsin C

2023

In this paper, we present the solvolysis reaction of dipeptide analogues of fluorinated aminophosphonates with simultaneous quantitative deprotection of the amino group. To the best of our knowledge, this work is the first reported example of the application of fluorinated aminophosphonates in cathepsin C inhibition studies. The new molecules show moderate inhibition of the cathepsin C enzyme, which opens the door to consider them as potential therapeutic agents. Overall, our findings provide a new avenue for the development of fluorinated aminophosphonate-based inhibitors. This article is part of the thematic issue "Organophosphorus chemistry: from model to application".

Study of locomotion response and development in zebrafish (Danio rerio) embryos and larvae exposed to enniatin A, enniatin B, and beauvericin.

2021

Mycotoxins are secondary metabolites produced by a variety of fungi that contaminate food and feed resources, and are capable of inducing a wide range of toxicity. Here, we studied the developmental and behavioral toxicity in zebrafish (Danio rerio) embryos and larvae exposed to three mycotoxins: beauvericin (BEA), Enniatin A (ENN A), and Ennitain B (ENN B). Zebrafish embryos were collected after fertilization, treated individually from 1 to 6 dpf with BEA at 8, 16, 32 and, 64 μM and for both enniatins at 3.12, 6.25, 12.5 and, 25 μM. Mixture of mycotoxins were assayed as follows: i) for BEA + ENN A and BEA + ENN B at [32 + 12.5] μM and [16 + 6.25] μM; ii) for ENN A + ENN B at [12.5 + 12.5] …

Hsp60 response in experimental and human temporal lobe epilepsy due to hyppocampal sclerosis

2015

Hsp60 is widely distributed in the brain, and its alteration has been involved in different neurological disorders. Epilepsy is considered one of the most common neurological disorders and typically involves the hippocampal formation. Compelling evidence describes a role of mitochondria, oxidative stress and both innate and adaptive immunity during epileptogenesis in temporal lobe epilepsy due to hyppocampal sclerosis (TLE-HS). Here, we investigate the Hsp60 involvement in experimental and human epilepsy. Firstly, expression and distribution of Hsp60 in epileptic hippocampi of a rat model of temporal lobe epilepsy (TLE), based on the phenomenon of maximal dentate gyrus activation (MDA), usi…