Search results for "eps"

Loss of input from the mossy cells blocks maturation of newly generated granule cells.

2007

The objective of this work is to check whether the input from the mossy cells to the inner molecular layer is necessary for the integration and maturation of the newly generated granule cells of the dentate gyrus (DG) in mice, and if after status epilepticus the sprouting of the mossy fibers can substitute for this projection. Newly generated cells were labeled by administration of 5-bromo-deoxyuridine either before or after pilocarpine administration. The neuronal loss in the hippocampus after administration of pilocarpine combined with scopolamine and diazepam seemed restricted to the hilar mossy cells. The maturation of the granule cells was studied using immunohistochemistry for calreti…

Splendor et gloria Domus Joannae

1672

Esc. de la Companyia de Jesús en antep. Esc. calc. de Honorat Joan Centelles, Marqués de Centelles en p. [3] y en p. 123, retrat calc. del mateix en f. de làm. Sign.: *4, **4, A-Z4, Aa-Ff4, Gg2. - Errates en la pag.

The electrophysiology of adenosine in the mammalian central nervous system

1991

AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.

2010

The CB1 cannabinoid receptor is the most abundant G-protein coupled receptor in the brain and a key regulator of neuronal excitability. There is strong evidence that CB1 receptor on glutamatergic hippocampal neurons is beneficial to alleviate epileptiform seizures in mouse and man. Therefore, we hypothesized that experimentally increased CB1 gene dosage in principal neurons would have therapeutic effects in kainic acid (KA)-induced hippocampal pathogenesis. Here, we show that virus-mediated conditional overexpression of CB1 receptor in pyramidal and mossy cells of the hippocampus is neuroprotective and moderates convulsions in the acute KA seizure model in mice. We introduce a recombinant a…

What are the effects of the aging of the neuromuscular system on postural stability?

2015

International audience; Aging is frequently associated with a decreased postural stability, essentially after 60 years, leading to an increased risk of falling. In this article we propose to highlight the influence of the aging of the neuromuscular system on postural stability when standing upright. To maintain balance while standing upright, human needs to control the activity of ankle muscles and particularly the plantar flexors. During the aging process, the performance of these muscles are strongly altered. It is commonly observed large deficits in elderly people with history of falls. Some authors reported an inverse correlation between the amplitude of postural sway and the capacity o…

Cortical Temperature Change: A Tool for Modulating Brain States?12

2016

Reduction in temperature depolarizes neurons by a partial closure of potassium channels but decreases the vesicle release probability within synapses. Compared with cooling, neuromodulators produce qualitatively similar effects on intrinsic neuronal properties and synapses in the cortex. We used this similarity of neuronal action in ketamine-xylazine-anesthetized mice and non-anesthetized mice to manipulate the thalamocortical activity. We recorded cortical electroencephalogram/local field potential (LFP) activity and intracellular activities from the somatosensory thalamus in control conditions, during cortical cooling and on rewarming. In the deeply anesthetized mice, moderate cortical co…

Microsurgical Anatomy of the Insular Region and Operculoinsular Association Fibers and its Neurosurgical Application

2019

Objective To analyze the three-dimensional relationships of the operculoinsular compartments, using standard hemispheric and white matter fiber dissection and review the anatomy of association fibers related to the operculoinsular compartments of the Sylvian fissure and the main white matter tracts located deep into the insula. The secondary aim of this study was to improve the knowledge on this complex region to safely address tumor, vascular, and epilepsy lesions with an integrated perspective of the topographic and white matter fiber anatomy using 2D and 3D photographs. Methods Six cadaveric hemispheres were dissected. Two were fixed with formalin and the arteries were injected with red …

What is Alloxysta fulviceps (Curtis, 1838) (Hymenoptera: Cynipoidea:Figitidae: Charipinae)?

2011

Pujade-Villar, J., Ferrer-Suay, M., Selfa, J. and Alonso-Zarazaga, M.A. 2011. What is Alloxysta fulviceps (Curtis, 1838) (Hymenoptera: Cynipoidea: Figitidae: Charipinae)?. Memoirs of Museum Victoria 68: 67–70. The validity of Alloxysta fulviceps (Curtis, 1838) and its synonymies have been examined. After studying the type series and the taxonomic history of this species, we conclude that the lectotype was wrongly designated. A new lectotype is designated and A. fulviceps is synonymised with A. victrix (Westwood, 1833).

Bioinspired self-assembly of tyrosinase-modified silicatein and fluorescent core-shell silica spheres.

2014

Inspired by the intermolecular cross-linking of mussel foot proteins and their adhesive properties, tyrosinase has been used to modify recombinant silicatein. DOPA/DOPAquinone-mediated cross-linking and interfacial interactions enhanced both self-assembly of silicatein building blocks and templating of core–shell silica spheres, resulting in fluorescent biomimetic silicatein–silica hybrid mesofibers.

Interaction effects of enniatin B, deoxinivalenol and alternariol in Caco-2 cells.

2015

Enniatin B (ENN B), deoxinivalenol (DON) and alternariol (AOH) are secondary metabolites of filamentous fungi. These mycotoxins are contaminants of vegetables and cereals. They are cytotoxic and their effects are enhanced by their mixtures. The objectives of this study were to compare the cytotoxicity of ENN B, DON and AOH alone or in combination in human adenocarcinoma (Caco-2) cells and to evaluate the type of interactions of mycotoxin mixtures by the isobologram analysis. Cells were treated with concentrations ranging from 1.85 to 90μM (AOH) and from 0.312 to 10μM (for ENN B and DON), individually and in combination of two and three mycotoxins (from 1.85 to 30μM for AOH and from 0.312 to…