Search results for "erk"
showing 10 items of 2599 documents
Cytokeratin 20 Is a General Marker of Cutaneous Merkel Cells While Certain Neuronal Proteins Are Absent
1995
Merkel cells are difficult to identify in tissue sections. Previous studies have used cytokeratins (CK) 8, 18, and 19 as histologic markers of Merkel cells. However, these CKs are also expressed in some outer root sheath keratinocytes and some early fetal epidermal cells and thus are not truly specific of Merkel cells in general. Using selective antibodies against a newly described CK, number 20--originally found in intestinal epithelium and Merkel cell carcinomas--in comparison to a key protein of neuroendocrine cells, chromogranin A, we established CK 20 as a specific Merkel cell marker in skin of humans, pigs, and mice. CK 20 seems to be an even more general and sensitive Merkel cell mar…
Pitfall prayer marks: Recognition and appropriate treatment: A case report and review of literature.
2019
Prayer marks are asymptomatic callosities resulting from repeated, extended pressure, and friction exerted on bony prominences when praying on hard ground. A 41-year-old woman with ulcerative colitis treated with infliximab was referred to our clinic due to skin changes on her feet that were suspected to be drug eruptions. The patient presented several asymptomatic, hyperpigmented, and hyperkeratotic plaques over the lateral malleoli suggesting that the lesions had a mechanical cause. Further exploration revealed that the patient, a practicing Muslim, prays in a sitting position called "Julus" several times a day. After color marking, the lesions over the lateral feet left a precise imprint…
Brainstem reflex circuits revisited
2004
Our current understanding of brainstem reflex physiology comes chiefly from the classic anatomical-functional correlation studies that traced the central circuits underlying brainstem reflexes and establishing reflex abnormalities as markers for specific areas of lesion. These studies nevertheless had the disadvantage of deriving from post-mortem findings in only a few patients. We developed a voxel-based model of the human brainstem designed to import and normalize MRIs, select groups of patients with or without a given dysfunction, compare their MRIs statistically, and construct three-plane maps showing the statistical probability of lesion. Using this method, we studied 180 patients with…
State of the Art Literature Review on Network Anomaly Detection
2018
As network attacks are evolving along with extreme growth in the amount of data that is present in networks, there is a significant need for faster and more effective anomaly detection methods. Even though current systems perform well when identifying known attacks, previously unknown attacks are still difficult to identify under occurrence. To emphasize, attacks that might have more than one ongoing attack vectors in one network at the same time, or also known as APT (Advanced Persistent Threat) attack, may be hardly notable since it masquerades itself as legitimate traffic. Furthermore, with the help of hiding functionality, this type of attack can even hide in a network for years. Additi…
A Novel Deep Learning Stack for APT Detection
2019
We present a novel Deep Learning (DL) stack for detecting Advanced Persistent threat (APT) attacks. This model is based on a theoretical approach where an APT is observed as a multi-vector multi-stage attack with a continuous strategic campaign. To capture these attacks, the entire network flow and particularly raw data must be used as an input for the detection process. By combining different types of tailored DL-methods, it is possible to capture certain types of anomalies and behaviour. Our method essentially breaks down a bigger problem into smaller tasks, tries to solve these sequentially and finally returns a conclusive result. This concept paper outlines, for example, the problems an…
State of the Art Literature Review on Network Anomaly Detection with Deep Learning
2018
As network attacks are evolving along with extreme growth in the amount of data that is present in networks, there is a significant need for faster and more effective anomaly detection methods. Even though current systems perform well when identifying known attacks, previously unknown attacks are still difficult to identify under occurrence. To emphasize, attacks that might have more than one ongoing attack vectors in one network at the same time, or also known as APT (Advanced Persistent Threat) attack, may be hardly notable since it masquerades itself as legitimate traffic. Furthermore, with the help of hiding functionality, this type of attack can even hide in a network for years. Additi…
Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family
2011
Fibroblast growth factor receptor 1 (FGFR1) is known to be activated by homodimerization in the presence of both the FGF agonist ligand and heparan sulfate glycosaminoglycan. FGFR1 homodimers in turn trigger a variety of downstream signaling cascades via autophosphorylation of tyrosine residues in the cytoplasmic domain of FGFR1. By means of Bioluminescence Energy Resonance Transfer (BRET) as a sign of FGFR1 homodimerization, we evaluated in HEK293T cells the effects of all known FGF agonist ligands on homodimer formation. A significant correlation between BRET(2) signaling and ERK1/2 phosphorylation was observed, leading to a further characterization of the binding and signaling properties…
Amigaskene, alakulttuuri tietokoneen puitteissa : kuvauksia alakulttuurin ja teknologioiden yhteenkietoutumisesta
2008
Tutkielman aiheena on tietokoneharrastajien alakulttuuri, jota kutsutaan Amigaskeneksi. Tutkielmassa tarkastellaan ensinnäkin niitä kulttuurin ja tietotekniikan puitteita, joiden viitekehyksessä tietokone harrastajat toimivat. Alakulttuurina Amigaskene sijoittuu yhtäältä sitä ympäröivien kulttuurien, kuten vallitsevan yhteiskunnan ja Amigaskeneä edeltävän skene-alakulttuurin, kehiin ja toisaalta Amigan mahdollistamaan tietotekniseen viitekehykseen. Lisäksi tutkielmassa tarkastellaan teknologiavälitteisen alakulttuurin puitteisiin rakentuneita kulttuurisia aineksia, joiden johdosta alakulttuuri erottuu kulttuuriksi. Tutkielmassa käytetään alakulttuurin määritelmää ja toimijaverkostoteoriaa a…
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling
2014
The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are mediated largely through changes in signal transduction pathways such as the mitogen-activated protein kinase c-Jun N-terminal kinase (JNK). In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury. These effects are mediated in larg…
Closed form coefficients in the Symmetric Boundary Element Approach
2006
Abstract In the area of the structural analysis, the problems connected to the use of the symmetric Galerkin Boundary Element Method (SGBEM) must be investigated especially in the mathematical and computational difficulties that are present in computing the solving system coefficients. Indeed, any coefficient is made by double integrals including often fundamental solutions having a high degree of singularity. Therefore, the related computation proves to be difficult in the solution. This paper suggests a simple computation technique of the coefficients obtained in closed form. Using a particular matrix, called ‘progenitor’ matrix [Panzeca T, Cucco F, Terravecchia S. Symmetric boundary elem…