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showing 10 items of 13546 documents
Input of P, N-(phosphanyl, amino)-ferrocene hybrid derivatives in late transition metals catalysis
2018
International audience; Unequally functionalized ferrocenes give access to valuable hemilabile reactivity in catalytic reaction. We address the synthesis of hybrid (P, N)-ferrocenyl compounds for which recent catalytic breakthrough applications have been reported, transversely in late transition metals chemistry. Palladium, nickel, rhodium, iridium, and emerging iron and gold catalysis are illustrated from selected examples, which include CC bond formation from cross-coupling and polymerization, allylic substitution, cyanation, hydroformylation, CH arylation and silylation and hydrogenation reactions.
Cyclopentadienylmolybdenum(II) and -(III) complexes containing diene and allyl ligands. Part 4. Reactivity studies of the bisallyl complex CpMo(supin…
1998
Abstract Compound CpMo( η 3 -C 3 H 5 ) 2 , 3, has been synthesized from CpMoCl 4 and four equivalents of allylmagnesium bromide. While the compound is stable in donor solvents at room temperature, warming in refluxing MeCN induces the formation of 1,5-hexadiene by a metal-mediated allyl-allyl coupling process. Treatment of 3 with Bu t NC at room temperature affords CpMo( η 3 -C 3 H 5 )(Bu t NC) 2 , 4. A similar reduction with presumed allyl radical loss occurs for [CpMo( η 3 -C 3 H 5 )( η 4 -C 4 H 6 )] + , [1c] + , to afford [CpMo( η 4 -C 4 H 6 )(Bu t NC) 2 ] + , 5. Treatment of [1c] + with methyllithium affords two products, the major one (1c) corresponding to the one-electron reduction pa…
Cellular stress induces cap-independent alpha-enolase/MBP-1 translation.
2015
AbstractMyc promoter-binding protein-1 (MBP-1) is a shorter protein variant of the glycolytic enzyme alpha-enolase. Although several lines of evidence indicate that MBP-1 acts as a tumor suppressor, the cellular mechanisms and signaling pathways underlying MBP-1 expression still remain largely elusive. To dissect these pathways, we used the SkBr3 breast cancer cell line and non-tumorigenic HEK293T cells ectopically overexpressing alpha-enolase/MBP-1. Here, we demonstrate that induced cell stresses promote MBP-1 expression through the AKT/PERK/eIF2α signaling axis. Our results contribute to shedding light on the molecular mechanisms underlying MBP-1 expression in non-tumorigenic and cancer c…
Enantiodifferentiation of acyclic phosphonium salts in chiral liquid crystalline solutions
2006
Abstract The enantiodifferentiation of acyclic phosphonium salts bearing a stereogenic centre, whether on the phosphorus atom or on one of its substituents, was investigated by 2 H–{ 1 H}, 13 C–{ 1 H} and 31 P–{ 1 H} NMR in chiral liquid crystals composed of a polypeptide dissolved in an organic solvent. For the first time, the enantiomers of P-chirogenic phosphorus compounds were discriminated in these anisotropic media, affording good to excellent separation of the signals, allowing the determination of their proportion. While 31 P–{ 1 H} NMR spectra showed no chiral separation, 2 H–{ 1 H} NMR was efficient in the enantiodifferentiation of an isotopically labelled compound. Better still, …
Optical measurements of ground-state properties of short-lived nuclei in resonance cells
1985
Hyperfine structure and isotope shift of radioactive Hg, Au and Cd isotopes have been determined by optical spectroscopy. In all cases the atoms were confined in a resonance cell. The various variants of the cell technique and alternative methods as the resonance ionization spectroscopy related to the investigation of short-lived nuclei are described, and some results are discussed.
Efficient Addition of Acid Enediolates to Epoxides
2004
We report new conditions to facilitate the addition of dianions of carboxylic acids to epoxides as an alternative method to the use of aluminum enolates. These conditions require the use of a sub-stoichiometric (10%) amount of amine for dianion generation and the previous activation of the epoxide with LiCl. Other Lewis acids have been shown to be less effective. Yields are good but only low diastereoselectivity is attained, which has not been controlled despite attempts at optimization. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Studio di segmentazione morfovolumetrica in pazienti con declino cognitivo lieve amnestico (aMCI) e demenza di Alzheimer (AD) rispetto ad un gruppo d…
2016
SCOPO: Presentare i risultati preliminari di un’analisi di segmentazione morfovolumetrica (VBM) eseguita in pazienti con aMCI ed AD rispetto ad una popolazione di controllo (NAB). Tali dati saranno in futuro correlati ad altri parametri clinico-psicologici raccolti (età, sesso, scolarità, MMSE, ADL, IADL). MATERIALI E METODI: Sono stati sottoposti ad esame RM encefalo 103 soggetti, utilizzando uno scanner RM GE Signa HDxt da 1,5T ed acquisendo, tra le altre, una sequenza Sag 3D T1 FSPGR IR preped ASSET che è stata utilizzata per l’analisi VBM eseguita con il tool sienax (FSL). I risultati sono stati valutati in termini di valori medi e deviazioni standard mediante applicazione del t-test…
Biomarkers Related to Synaptic Dysfunction to Discriminate Alzheimer’s Disease from Other Neurological Disorders
2022
Recently, the synaptic proteins neurogranin (Ng) and α-synuclein (α-Syn) have attracted scientific interest as potential biomarkers for synaptic dysfunction in neurodegenerative diseases. In this study, we measured the CSF Ng and α-Syn concentrations in patients affected by AD (n = 69), non-AD neurodegenerative disorders (n-AD = 50) and non-degenerative disorders (n-ND, n = 98). The concentrations of CSF Ng and α-Syn were significantly higher in AD than in n-AD and n-ND. Moreover, the Aβ42/Ng and Aβ42/α-Syn ratios showed statistically significant differences between groups and discriminated AD patients from n-AD patients, better than Ng or α-Syn…
Chemical Characterization and Cytotoxic and Antioxidant Activity Evaluation of the Ethanol Extract from the Bulbs of Pancratium maritimun Collected i…
2023
P. maritimum L., belonging to the Amaryllidaceae family, is a species that grows on beaches and coastal sand dunes mainly on both sides of the Mediterranean Sea and Black Sea, the Middle East, and up to the Caucasus region. It has been largely investigated due to its several interesting biological properties. With the aim of providing new insights into the phytochemistry and pharmacology of this species, the ethanolic extract of the bulbs from a local accession, not previously studied, growing in Sicily (Italy), was investigated. This chemical analysis, performed by mono- and bi-dimensional NMR spectroscopy, as well as LC-DAD-MSn, allowed to identify several alkaloids, three of which were n…